Search Results - "Kintzing, James"

Engineered knottin peptides as diagnostics, therapeutics, and drug delivery vehicles by Kintzing, James R, Cochran, Jennifer R

“…[Display omitted] •Knottins are small constrained peptides with ultra-high stability.•New binding epitopes can be introduced into natural knottins using…”
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Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo by Nelson, Christopher E, Kintzing, James R, Hanna, Ann, Shannon, Joshua M, Gupta, Mukesh K, Duvall, Craig L

“…A family of pH-responsive diblock polymers composed of poly[(ethylene glycol)-b-[(2-(dimethylamino)ethyl methacrylate)-co-(butyl methacrylate)],…”
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Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation by Cox, Nick, Kintzing, James R., Smith, Mark, Grant, Gerald A., Cochran, Jennifer R.

“…Antibody–drug conjugates (ADCs) offer increased efficacy and reduced toxicity compared to systemic chemotherapy. Less attention has been paid to peptide–drug…”
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An engineered ultrahigh affinity bi‐paratopic uPAR targeting agent confers enhanced tumor targeting by Cherf, Gerald M., Lee, Robert B., Mehta, Nishant, Clifford, Claire, Torres, Kathleen, Kintzing, James R., Cochran, Jennifer R.

“…Urokinase‐type plasminogen activator receptor (uPAR) is overexpressed on tumor cells in multiple types of cancer and contributes to disease progression and…”
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Emerging Strategies for Developing Next-Generation Protein Therapeutics for Cancer Treatment by Kintzing, James R, Filsinger Interrante, Maria V, Cochran, Jennifer R

“…Protein-based therapeutics have been revolutionizing the oncology space since they first appeared in the clinic two decades ago. Unlike traditional…”
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Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis by Currier, Nicolas V, Ackerman, Shelley E, Kintzing, James R, Chen, Rishard, Filsinger Interrante, Maria, Steiner, Alexander, Sato, Aaron K, Cochran, Jennifer R

“…Antibody-drug conjugates (ADC) have generated significant interest as targeted therapeutics for cancer treatment, demonstrating improved clinical efficacy and…”
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Structural Basis of the Differential Binding of Engineered Knottins to Integrins αVβ3 and α5β1 by Van Agthoven, Johannes F., Shams, Hengameh, Cochran, Frank V., Alonso, José L., Kintzing, James R., Garakani, Kiavash, Adair, Brian D., Xiong, Jian-Ping, Mofrad, Mohammad R.K., Cochran, Jennifer R., Arnaout, M. Amin

“…Targeting both integrins αVβ3 and α5β1 simultaneously appears to be more effective in cancer therapy than targeting each one alone. The structural requirements…”
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Sports-related brain injuries: connecting pathology to diagnosis by Pan, James, Connolly, Ian D, Dangelmajer, Sean, Kintzing, James, Ho, Allen L, Grant, Gerald

“…Brain injuries are becoming increasingly common in athletes and represent an important diagnostic challenge. Early detection and management of brain injuries…”
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Inside Cover: Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation (Angew. Chem. Int. Ed. 34/2016) by Cox, Nick, Kintzing, James R., Smith, Mark, Grant, Gerald A., Cochran, Jennifer R.

“…A knottin miniprotein first isolated from the seeds of the squirting cucumber has been engineered to bind selectively to tumor‐associated integrin receptors…”
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Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation by Cox, Nick, Kintzing, James R., Smith, Mark, Grant, Gerald A., Cochran, Jennifer R.

“…Antibody–drug conjugates (ADCs) offer increased efficacy and reduced toxicity compared to systemic chemotherapy. Less attention has been paid to peptide–drug…”
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A Bioengineered Peptide that Localizes to and Illuminates Medulloblastoma: A New Tool with Potential for Fluorescence-Guided Surgical Resection by Ackerman, Shelley E, Wilson, Christy M, Kahn, Suzana A, Kintzing, James R, Jindal, Darren A, Cheshier, Samuel H, Grant, Gerald A, Cochran, Jennifer R

“…Tumors of the central nervous system are challenging to treat due to the limited effectiveness and associated toxicities of chemotherapy and radiation therapy…”
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A Toolbox of Peptide-Drug Conjugates for Targeted Chemotherapy by Kintzing, James Reese

“…Traditional cancer chemotherapeutics often have narrow ranges between their effective and toxic doses. To improve efficacy and minimize side effects,…”
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Innentitelbild: Integrin‐Targeting Knottin Peptide–Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation (Angew. Chem. 34/2016) by Cox, Nick, Kintzing, James R., Smith, Mark, Grant, Gerald A., Cochran, Jennifer R.

“…Ein Knottin‐Miniprotein das zuerst aus den Samen der Spritzgurke isoliert wurde, konnte für die selektive Bindung an tumorassoziierte Integrinrezeptoren…”
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Innentitelbild: Integrin-Targeting Knottin Peptide-Drug Conjugates Are Potent Inhibitors of Tumor Cell Proliferation (Angew. Chem. 34/2016) by Cox, Nick, Kintzing, James R., Smith, Mark, Grant, Gerald A., Cochran, Jennifer R.

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