Search Results - "Kinsey, Berma"

Vaccines against drugs of abuse: where are we now? by Kinsey, Berma

“…Drug addiction is a serious problem worldwide. One therapy being investigated is vaccines against drugs of abuse. The antibodies elicited against the drug can…”
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Probing cocaine-antibody interactions in buffer and human serum by Ramakrishnan, Muthu, Alves De Melo, Fernando, Kinsey, Berma M, Ladbury, John E, Kosten, Thomas R, Orson, Frank M

“…Despite progress in cocaine immunotherapy, the kinetic and thermodynamic properties of antibodies which bind to cocaine and its metabolites are not well…”
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A vaccine against methamphetamine attenuates its behavioral effects in mice by Shen, Xiaoyun Y, Kosten, Therese A, Lopez, Angel Y, Kinsey, Berma M, Kosten, Thomas R, Orson, Frank M

“…Abstract Background Vaccines have treatment potential for methamphetamine (MA) addiction. We tested whether a conjugate vaccine against MA…”
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A morphine conjugate vaccine attenuates the behavioral effects of morphine in rats by Kosten, Therese A., Shen, Xiaoyun Y., O'Malley, Patrick W., Kinsey, Berma M., Lykissa, Ernest D., Orson, Frank M., Kosten, Thomas R.

“…Vaccines for opioid dependence may provide a treatment that would reduce or slow the distribution of the drug to brain, thus reducing the drug's reinforcing…”
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Substance Abuse Vaccines by Orson, Frank M., Kinsey, Berma M., Singh, Rana A.K., Wu, Yan, Gardner, Tracie, Kosten, Thomas R.

“…Conventional substance‐abuse treatments have only had limited success for drugs such as cocaine, nicotine, methamphetamine, and phencyclidine. New approaches,…”
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Anti-drug vaccines to treat substance abuse by Kinsey, Berma M, Jackson, David C, Orson, Frank M

“…Substance abuse is a growing world‐wide problem. The big four drugs of abuse that might lend themselves to immunotherapy are nicotine, cocaine, morphine/heroin…”
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Altered methamphetamine place conditioning in mice vaccinated with a succinyl-methamphetamine-tetanus-toxoid vaccine by Haile, Colin N., Kosten, Therese A., Shen, Xiaoyun Y., O'Malley, Patrick W., Winoske, Kevin J., Kinsey, Berma M., Wu, Yan, Huang, Zhen, Lykissa, Ernest D., Naidu, Naga, Cox, Joseph A., Arora, Reetakshi, Kosten, Thomas R., Orson, Frank M.

“…Background and Objectives We previously reported that an anti‐methamphetamine (MA) vaccine attenuated drug‐conditioned effects in mice, but it used a carrier…”
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Hapten Optimization for Cocaine Vaccine with Improved Cocaine Recognition by Ramakrishnan, Muthu, Kinsey, Berma M., Singh, Rana A., Kosten, Thomas R., Orson, Frank M.

“…In the absence of any effective pharmacotherapy for cocaine addiction, immunotherapy is being actively pursued as a therapeutic intervention. While several…”
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Anti-cocaine vaccine development by Kinsey, Berma M, Kosten, Thomas R, Orson, Frank M

“…Cocaine abuse is an ongoing and serious problem that has led to the growth of a brutal criminal enterprise, particularly in the Americas and Europe. At…”
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Combined cocaine hydrolase gene transfer and anti-cocaine vaccine synergistically block cocaine-induced locomotion by Carroll, Marilyn E, Zlebnik, Natalie E, Anker, Justin J, Kosten, Thomas R, Orson, Frank M, Shen, Xiaoyun, Kinsey, Berma, Parks, Robin J, Gao, Yang, Brimijoin, Stephen

“…Mice and rats were tested for reduced sensitivity to cocaine-induced hyper-locomotion after pretreatment with anti-cocaine antibody or cocaine hydrolase (CocH)…”
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The future potential for cocaine vaccines by Orson, Frank M, Wang, Rongfu, Brimijoin, Stephen, Kinsey, Berma M, Singh, Rana Ak, Ramakrishnan, Muthu, Wang, Helen Y, Kosten, Thomas R

“…Addiction to cocaine is a major problem around the world, but especially in developed countries where the combination of wealth and user demand has created…”
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Dose-dependent changes in the locomotor responses to methamphetamine in BALB/c mice: Low doses induce hypolocomotion by Singh, Rana A.K., Kosten, Therese A., Kinsey, Berma M., Shen, Xiaoyun, Lopez, Angel Y., Kosten, Thomas R., Orson, Frank M.

“…The overall goal of the present study was to determine the effects of different doses of (+)-methamphetamine (meth) on locomotor activity of Balb/C mice. Four…”
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Attenuation of cocaine-induced locomotor activity in male and female mice by active immunization by Kosten, Therese A., Shen, Xiaoyun Y., Kinsey, Berma M., Kosten, Thomas R., Orson, Frank M.

“…Background and Objectives Immunotherapy for drug addiction is being investigated in several laboratories but most studies are conducted in animals of one sex…”
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Vaccines for cocaine abuse by Orson, Frank M., Kinsey, Berma M., Singh, Rana A.K., Wu, Yan, Kosten, Thomas R.

“…Treatments for cocaine abuse have been disappointingly ineffective, especially in comparison with those for some other abused substances. A new approach, using…”
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Aerosol Delivery of Robust Polyethyleneimine– DNA Complexes for Gene Therapy and Genetic Immunization by Densmore, Charles L., Orson, Frank M., Xu, Bo, Kinsey, Berma M., Waldrep, J.Clifford, Hua, Pascal, Bhogal, Balbir, Knight, Vernon

“…Aerosol delivery of plasmid DNA to the lungs offers the possibility of direct application of gene preparations to pulmonary surfaces as a means of treating a…”
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The future of vaccines in the management of addictive disorders by Orson, Frank M, Kinsey, Berma M, Singh, Rana A K, Wu, Yan, Gardner, Tracie, Kosten, Thomas R

“…Conventional substance abuse treatments have had only limited success. As a result, new approaches, including vaccination to block the effects of drugs such as…”
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Non-viral gene delivery to the lungs by Kinsey, Berma M, Densmore, Charles L, Orson, Frank M

“…The lung represents an important target for gene therapy: for correction of genetic abnormalities such as cystic fibrosis, for lung cancer therapy, and for…”
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Protection against influenza infection by cytokine-enhanced aerosol genetic immunization by Orson, Frank M., Kinsey, Berma M., Densmore, Charles L., Nguyen, Tina, Wu, Yan, Mbawuike, Innocent N., Wyde, Philip R.

“…Background Conventional vaccine development for newly emerging pandemic influenza virus strains would likely take too long to prevent devastating global…”
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Genetic Immunization with Lung-Targeting Macroaggregated Polyethyleneimine-Albumin Conjugates Elicits Combined Systemic and Mucosal Immune Responses by Orson, Frank M, Kinsey, Berma M, Hua, Pascal J, Bhogal, Balbir S, Densmore, Charles L, Barry, Michael A

“…Genetic immunization is a novel form of vaccination in which transgenes are delivered into the host to produce the foreign protein within host cells. Although…”
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Vaccines against stimulants: cocaine and MA by Kosten, Thomas, Domingo, Coreen, Orson, Frank, Kinsey, Berma

“…While the worldwide prevalence of cocaine use remains significant, medications, or small molecule approaches, to treat drug addictions have met with limited…”
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