Search Results - "Kinsella, Francesca A. M."

PD-1 is imprinted on cytomegalovirus-specific CD4+ T cells and attenuates Th1 cytokine production whilst maintaining cytotoxicity by Parry, Helen M, Dowell, Alexander C, Zuo, Jianmin, Verma, Kriti, Kinsella, Francesca A M, Begum, Jusnara, Croft, Wayne, Sharma-Oates, Archana, Pratt, Guy, Moss, Paul

“…PD-1 is expressed on exhausted T cells in cancer patients but its physiological role remains uncertain. We determined the phenotype, function and…”
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PD-1 expression contributes to functional impairment of NK cells in patients with B-CLL by Farhat, Mustafa, Croft, Wayne, Parry, Helen M., Verma, Kriti, Kinsella, Francesca A. M., Xu, Jinsong, Bone, David, McSkeane, Tina, Paneesha, Shankara, Pratt, Guy, Moss, Paul, Zuo, Jianmin

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Establishment and functioning of intrathymic microenvironments by Anderson, Graham, Jenkinson, William E., Jones, Terry, Parnell, Sonia M., Kinsella, Francesca A. M., White, Andrea J., Pongrac'z, Judit E., Rossi, Simona W., Jenkinson, Eric J.

“…The thymus supports the production of self‐tolerant T cells from immature precursors. Studying the mechanisms regulating the establishment and maintenance of…”
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Early inflammatory markers as prognostic indicators following allogeneic stem cell transplantation by Verma, Kriti, Croft, Wayne, Greenwood, David, Stephens, Christine, Malladi, Ram, Nunnick, Jane, Zuo, Jianmin, Kinsella, Francesca A M, Moss, Paul

“…Allogeneic stem cell transplantation is used widely in the treatment of hematopoietic malignancy although graft versus host disease and relapse remain major…”
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Brief cycling intervals incrementally increase the number of hematopoietic stem and progenitor cells in human peripheral blood by Pradana, Fendi, Nijjar, Tarondeep, Cox, Phoebe A, Morgan, Paul T, Podlogar, Tim, Lucas, Samuel J E, Drayson, Mark T, Kinsella, Francesca A M, Wadley, Alex J

“…Peripheral blood stem cell (PBSC) donation is the primary procedure used to collect hematopoietic stem and progenitor cells (HSPCs) for hematopoietic stem cell…”
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Strategies to reduce relapse risk in patients undergoing allogeneic stem cell transplantation for acute myeloid leukaemia by Kinsella, Francesca A M, Maroto, Maria A L, Loke, Justin, Craddock, Charles

“…Allogeneic stem cell transplantation is a centrally important curative strategy in adults with acute myeloid leukaemia; however, relapse occurs in a…”
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Integrating patient and public involvement and engagement in translational medicine by Shaw, Karen L, Calvert, Melanie J, Borrow, Persephone, Chakera, Evelyn, Chakraverty, Ronjon, Hughes, Sarah E, Khatsuria, Foram, Kinsella, Francesca A M, McMullan, Christel, Richardson-Abraham, Julie, Yarosh, Vlada, Aiyegbusi, Olalekan Lee

“…[...]despite the successful development of effective COVID-19 vaccines, the complex issue of vaccine hesitancy revealed the crucial role of social determinants…”
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UK national audit of extracorporeal photopheresis (ECP) in chronic graft versus host disease by Kinsella, Francesca A. M., Bencito, Alvin, Kulik, Daniela, Hurst, Erin, Gilleece, Maria, Snowden, John A., Malladi, Ram, Scarisbrick, Julia, Gennery, Andrew, Alfred, Arun

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CD70 identifies alloreactive T cells and represents a potential target for prevention and treatment of acute GVHD by Verma, Kriti, Croft, Wayne, Margielewska-Davies, Sandra, Pearce, Hayden, Stephens, Christine, Diaconescu, Diana, Bevington, Sarah, Craddock, Charles, Amel-Kashipaz, Rasoul, Zuo, Jianmin, Kinsella, Francesca A. M., Moss, Paul

“…•Proinflammatory CD70+ T cells develop after HSCT and are enriched in blood and tissue at the time of aGVHD.•Blockade of CD70 on T cells reduces…”
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Very early lineage-specific chimerism after reduced intensity stem cell transplantation is highly predictive of clinical outcome for patients with myeloid disease by Kinsella, Francesca A.M., Inman, Charlotte F., Gudger, Amy, Chan, Yuen T., Murray, Duncan J., Zuo, Jianmin, McIlroy, Graham, Nagra, Sandeep, Nunnick, Jane, Holder, Kathy, Wall, Kerry, Griffiths, Mike, Craddock, Charles, Nikolousis, Emmanouil, Moss, Paul, Malladi, Ram

“…[Display omitted] •Chimerism within PBMC and T cells at day 50 after allo-SCT defines three groups.•Relapse risk for myeloid disease is high if mixed chimerism…”
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Early expression of CD94 and loss of CD96 on CD8+ T cells after allogeneic stem cell tranplantation is predictive of subsequent relapse and survival by Verma, Kriti, Croft, Wayne, Pearce, Hayden, Zuo, Jianmin, Stephens, Christine, Nunnick, Jane, Kinsella, Francesca Am, Malladi, Ram, Moss, Paul

“…Allogeneic stem cell transplantation is used widely in the treatment of hematopoietic malignancy. However, relapse of malignant disease is the primary cause of…”
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Mixed chimerism established by hematopoietic stem cell transplantation is maintained by host and donor T regulatory cells by Kinsella, Francesca A.M., Zuo, Jianmin, Inman, Charlotte F., Pearce, Hayden, Maggs, Luke, Eldershaw, Suzy E., Chan, Y. L. Tracey, Nunnick, Jane, Nagra, Sandeep, Griffiths, Mike, Craddock, Charles, Malladi, Ram, Moss, Paul

“…Transplantation is an effective treatment of many clinical disorders, but the mechanisms that regulate immunological tolerance are uncertain and remain central…”
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Donor-derived mycosis fungoides following reduced intensity haematopoietic stem cell transplantation from a matched unrelated donor by Kinsella, Francesca A M, Amel Kashipaz, Mohammad Rasoul, Scarisbrick, Julia, Malladi, Ram

“…A 46-year-old woman with a history of dasatinib-resistant chronic myeloid leukaemia, clonal evolution and monosomy 7 underwent reduced intensity conditioned in…”
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Split Mixed Donor Chimerism Early after T-Cell Depleted Reduced Intensity Conditioned Allogeneic Haematopoietic Stem Cell Transplantation Predicts Survival by Kinsella, Francesca A M, Gudger, Amy, Inman, Charlotte F, Mc Ilroy, Graham, Nagra, Sandeep, Nunnick, Jane, Waldron, Dave, Wall, Kerry, Griffiths, Mike, Moss, Paul, Craddock, Charles, Nikolousis, Emmanouil, Malladi, Ram

“…▪ The significance of mixed donor chimerism as a hallmark of an unsuccessful graft versus leukaemia effect and disease relapse is unclear. Whilst some studies…”
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Establishment and functioning of intrathymic micro environments: Thymus and lymphocyte development by ANDERSON, Graham, JENKINSON, William E, JONES, Terry, PARNELL, Sonia M, KINSELLA, Francesca A. M, WHITE, Andrea J, PONGRAC'Z, Judit E, ROSSI, Simona W, JENKINSON, Eric J

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