Search Results - "Kinoshita, Paula F."
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Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells
Published in Scientific reports (07-07-2017)“…Ouabain (OUA) is a cardiac glycoside that binds to Na + ,K + -ATPase (NKA), a conserved membrane protein that controls cell transmembrane ionic concentrations…”
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The Influence of Na(+), K(+)-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence
Published in Frontiers in physiology (02-06-2016)“…Decreased Na(+), K(+)-ATPase (NKA) activity causes energy deficiency, which is commonly observed in neurodegenerative diseases. The NKA is constituted of three…”
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Toll-like Receptor 4 Signaling is Critical for the Adaptive Cellular Stress Response Effects Induced by Intermittent Fasting in the Mouse Brain
Published in Neuroscience (15-06-2021)“…•Absence of TLR4 induced-fear memory deficit was not rescued by intermittent fasting.•Intermittent fasting reduced brain derived neurotrophic factor in absence…”
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A missense mutation converts the Na+,K+-ATPase into an ion channel and causes therapy-resistant epilepsy
Published in The Journal of biological chemistry (2021)“…The ion pump Na+,K+-ATPase is a critical determinant of neuronal excitability; however, its role in the etiology of diseases of the central nervous system…”
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Tumor necrosis factor receptor-associated factor 6 interaction with alpha-synuclein enhances cell death through the Nuclear Factor-kB pathway
Published in IBRO reports (01-12-2020)“…•TRAF6 binds to both WT and the mutant form A30 P asyn in SH-SY5Y cell model.•The activation of NF-κB leads to changes in cytokines levels induced by TRAF6 -…”
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