Significance of Nucleosides and a Nucleotide Mixture Infusion on Hepatic Energy Metabolism of 70% Hepatectomized Rabbits in Postoperative Phase

Background: The influence of administration of a nucleoside-nucleotide mixture on hepatic energy metabolism was investigated in 70% hepatectomized rabbits from 48 to 72 hours after hepatectomy. Methods: From 48 to 72 hours after hepatectomy, animals underwent continuous IV infusion of 2 mL/kg body w...

Full description

Saved in:

Bibliographic Details
Published in:	JPEN. Journal of parenteral and enteral nutrition Vol. 20; no. 3; pp. 211 - 214
Main Authors:	Jin, Maeng Bong, Yamaguchi, Tetsuya, Shimahara, Yasuyuki, Ichimiya, Masato, Kinoshita, Kolichi, Oka, Takahiro, Ozawa, Kazue, Yamaoka, Yoshio
Format:	Journal Article
Language:	English
Published:	Thousand Oaks, CA Sage Publications 01-05-1996 SAGE Publications ASPEN American Society for Parenteral and Enteral Nutrition
Subjects:	Adenine Nucleotides - analysis Animals Biological and medical sciences Catheterization, Central Venous DNA - analysis Energy Metabolism - drug effects Energy Metabolism - physiology Fundamental and applied biological sciences. Psychology Hepatectomy Infusions, Intravenous - methods Intermediate and energetic metabolism Liver - chemistry Liver - drug effects Liver - metabolism Liver Regeneration - drug effects Liver Regeneration - physiology Male Metabolisms and neurohumoral controls Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Nucleosides - administration & dosage Nucleosides - pharmacology Nucleotides - administration & dosage Nucleotides - pharmacology Phosphorylation Postoperative Period Rabbits Vertebrates: anatomy and physiology, studies on body, several organs or systems Postoperative Energetic equilibrium Intravenous administration Rabbit Lagomorpha Experimental study Metabolism Hepatectomy Vertebrata Mammalia Perfusion Surgery Animal Nucleotide Nucleoside
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Background: The influence of administration of a nucleoside-nucleotide mixture on hepatic energy metabolism was investigated in 70% hepatectomized rabbits from 48 to 72 hours after hepatectomy. Methods: From 48 to 72 hours after hepatectomy, animals underwent continuous IV infusion of 2 mL/kg body weight/h of 9 g/LNaCl (group S), 5.99 mmol/Lnucleoside-nucleotide mixture (group N1) or 11.98 mmol/L nucleoside-nucleotide mixture (group N2). Results: At 72 hours, there was no significant difference in the hepatic adenylate energy charge among groups (S, 0.84 ± 0.01; N1, 0.82 ± 0.02; N2, 0.85 ± 0.01). The hepatic mitochondrial phosphorylation rate was 66.9 ± 2.5, 76.3 ± 11.1, and 108.4 ± 14.1 nmol ATP/mg mitochondrial protein/ min in groups S, N1, and N2, respectively. The value of group N2 was significantly higher than the value of group S (p < .01). In addition, DNA concentration of the remnant liver was 2.27 ± 0.07, 2.56 ± 0.17, and 3.19 ± 0.42 mg/g wet liver in groups S, N1, and N2, respectively, showing a significant increase in group N2 compared with group S (p < .05). Conclusion: A continuous IV infusion of a nucleoside-nucleotide mixture to 70% hepatectomized rabbits from 48 to 72 hours after hepatectomy prolonged an enhancement of the hepatic mitochondrial phosphorylation rate and elevated DNA content of the remnant liver. (journal of Parenteral and Enteral Nutrition 20:211-214, 1996)
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0148-6071 1941-2444
DOI:	10.1177/0148607196020003211