Search Results - "Kinoshita, Kiyoshi"

Purification of Waste Silicon Powder Derived from Kerf Loss Slurry by Radial Directional Solidification and Comparison with Other Directional Solidification Practices by Imose, Minako, Araki, Daigo, Uddin, Md. Azhar, Kato, Yoshiei, Kinoshita, Kiyoshi

“…Radial directional solidification, in which a liquid is solidified toward the radial center, was explored as a technique for recycling kerf loss silicon powder…”
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Precificação ao Mercado das Exportações Brasileiras de Produtos Industrializados by Kannebley Júnior, Sérgio, Assahide, Leonardo Kiyoshi Kinoshita

“…Este trabalho testa a hipótese de precificação ao mercado para as exportadores brasileiras de produtos manufaturados. Por meio de modelos de correção de erros…”
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Preclinical and clinical properties of Bezlotoxumab (ZINPLAVA ® 25 mg/mL concentrate for solution for infusion), novel therapeutic agent for Clostridium difficile infection by Kinoshita, Kiyoshi

“…Clostridium difficile (C. difficile), an enterobacteria, flourishes and produces potent toxins, toxin A (TcdA) and toxin B (TcdB), after the disruption of the…”
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TRH receptor agonists ameliorate 3-acetylpyridine-induced ataxia through NMDA receptors in rats by Kinoshita, Kiyoshi, Watanabe, Yumi, Yamamura, Michio, Matsuoka, Yuzo

“…The effects of thyrotropin-releasing hormone (TRH) receptor agonists were examined on 3-acetylpyridine-induced cerebellar ataxia in rats. 3-acetylpyridine…”
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Considerations of the Japanese Research Working Group for the ICH S6 & Related Issues Regarding Nonclinical Safety Assessments of Oligonucleotide Therapeutics: Comparison with Those of Biopharmaceuticals by Hirabayashi, Yoko, Maki, Kazushige, Kinoshita, Kiyoshi, Nakazawa, Takahiro, Obika, Satoshi, Naota, Misaki, Watanabe, Kazuto, Suzuki, Mutsumi, Arato, Teruyo, Fujisaka, Aki, Fueki, Osamu, Ito, Kosuke, Onodera, Hiroshi

“…This white paper summarizes the current consensus of the Japanese Research Working Group for the ICH S6 & Related Issues (WGS6) on strategies for the…”
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Toxicologic Pathology Forum: Current Status on the Use of Animal Models of Human Disease in the Pharmaceutical Industry in Japan in Nonclinical Safety Assessment–Opinion Paper by Tomohiro, Masayuki, Okabe, Takeshi, Kimura, Yasushi, Kinoshita, Kiyoshi, Maeda, Mitsunori, Mitobe, Yuko, Motoyama, Keiko, Yonezawa, Riichiro, Sasaki, Shoji, Fujiwara, Michio, Watanabe, Kazuto

“…In nonclinical safety studies for new drug development, healthy animals have been commonly used. However, in some cases, the use of animal models of human…”
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A new method for evaluation of motor deficits in 3-acetylpyridine-treated rats by Watanabe, Yumi, Kinoshita, Kiyoshi, Koguchi, Atushi, Yamamura, Michio

“…We established a novel method for quantitative evaluation of the motor deficits induced by 3-acetylpyridine (3-AP) in rats. 3-AP (75 mg/kg, i.p.) was injected…”
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Distribution of Thyrotropin-Releasing Hormone (TRH) Receptors in the Brain of the Ataxic Mutant Mouse, Rolling Mouse Nagoya by KINOSHITA, Kiyoshi, YAMAMURA, Michio, SUGIHARA, Juko

“…Thyrotropin-releasing hormone (TRH) and its analog, TA-0910, ameliorate the ataxia of the mutant mouse, rolling mouse Nagoya, by metabolic normalization in the…”
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Effects of TA-0910, a novel orally active thyrotropin-releasing hormone analog, on the gait of ataxic animals by Kinoshita, Kiyoshi, Fujitsuka, Tatsuya, Yamamura, Michio, Matsuoka, Yuzo

“…The effects of TA-0910 (1-methyl-( S)-4,5-dihydroorotyl- l-histidyl- l-prolinamide), a new thyrotropin-releasing hormone (TRH: l-pyroglutamyl- l-histidyl-…”
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Preclinical and clinical properties of elbasvir (ERELSA ® Tablets 50 mg) and Grazoprevir (GRAZYNA ® Tablets 50 mg), novel therapeutic agents for hepatitis C by Kinoshita, Kiyoshi, Iwasa, Takashi, Asante-Appiah, Ernest, Nakamura, Keisuke

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Chronic Anti-ataxic Actions of the Novel Thyrotropin-Releasing Hormone (TRH) Analog, TA-0910, during and after Repeated Administration in Rolling Mouse Nagoya : Behavioral and Pharmacokinetic Studies by KINOSHITA, Kiyoshi, FUKUSHIMA, Takeshi, KODAMA, Yasuhiko, SUGIHARA, Juko, YAMAMURA, Michio, MATSUOKA, Yuzo

“…Anti-ataxic effects of TA-0910, a novel thyrotropin-releasing hormone analog, in mice of the ataxic mutant mouse strain Rolling mouse Nagoya (RMN) are…”
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Preclinical and clinical properties of vaniprevir (VANIHEP® Capsules 150 mg), a novel therapeutic agent for hepatitis C by Kinoshita, Kiyoshi, Iwasa, Takashi, Takase, Akiko, Nakamura, Keisuke

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Anti-apoptotic Effect of Acetyl-l-carnitine and l-Carnitine in Primary Cultured Neurons by Ishii, Taketoshi, Shimpo, Yasuko, Matsuoka, Yuzo, Kinoshita, Kiyoshi

“…Although exogenously administered acetyl−l−carnitine(ALCAR, (2−acetoxy−3−carboxypropyl)−trimethylammonium)and l−carnitine(LC,…”
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Diversity of Thyrotropin-Releasing Hormone Receptors in the Pituitary and Discrete Brain Regions of Rats by Hidetoshi, Asai, Kiyoshi, Kinoshita, Michio, Yamamura, Yuzo, Matsuoka

“…In order to analyze the receptor properties of central nervous system (CNS)-stimulant thyrotropin-releasing hormone (L-pyroglutamyl-L-histidyl-L-prolinamide,…”
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Effects of TRH analog, taltirelin hydrate (TA-0910), on the circulatory and respiratory failures and viable time following hemorrhagic shock in rats by Asai, Hidetoshi, Watanabe, Yumi, Matsuoka, Yuzo, Kinoshita, Kiyoshi

“…We investigated the effects of taltirelin hydrate (taltirelin, TA-0910),a novel thyrotropin-releasing hormone (TRH) analog, and TRH on the circulatory and…”
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A novel thyrotropin-releasing hormone analog, TA-0910, ameliorates 3-acetylpyridine-induced ataxia through NMDA receptors in rats by Kinoshita, Kiyoshi, Watanabe, Yumi, Yamamura, Michio, Matsuoka, Yuzo

“…Effects of TA-0910 ((-)-N-[(S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinylcarbonyl]-L-histidyl-L-prolinamide tetra-hydrate), a novel thyrotropin-releasing…”
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Metabolic Abnormalities Caused by 3-Acetylpyridine in the Cerebral Motor Regions of Rats: Partial Recovery by Thyrotropin-Releasing Hormone by Kinoshita, Kiyoshi, Watanabe, Yumi, Asai, Hidetoshi, Matsuoka, Yuzo

“…Although 3-acetylpyridine (3-AP) induces several motor disturbances and it degenerates the olivocerebellar pathway, abnormalities caused by 3-AP in cerebral…”
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Acetyl-L-carnitine(TA-803) and L-carnitine inhibit cell death induced by serum deprivation in primary cultured neurons by Ishii, Taketoshii, Shimpo, Yasuko, Okamoto, Masahito, Matsuoka, Yuzo, Kinoshita, Kiyoshi

“…Although exogenously administered acetyl-L-carnitine (ALC, TA-803) and L-carnitine (LC) prevent post-ischemic brain damage in several ischemic models, the…”
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Effect of TA-0910, a Novel Thyrotropin-Releasing Hormone Analog, on In Vivo Acetylcholine Release and Turnover in Rat Brain by Kinoshita, Kiyoshi, Kawashima, Kazutaka, Kawashima, Yumiko, Fukuchi, Isao, Yamamura, Michio, Matsuoka, Yuzo

“…To examine the action of a novel thyrotropin-releasing hormone (TRH) analog, TA-0910…”
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Pharmacological Study of TA-0910, a New Thyrotropin- Releasing Hormone (TRH) Analog (III): Inhibition of Pentobarbital Anesthesia by Yamamura, Michio, Kinoshita, Kiyoshi, Nakagawa, Hiroyuki, Ishida, Ryuichi

“…Sites and mechanisms of the antagonistic action of TA-0910, a new thyrotropin-releasing hormone (TRH) analog, on pentobarbital anesthesia were studied in rats…”
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