Search Results - "Kinosaki, Masahiko"

Identification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism by Tamura, Tatsuya, Noda, Hiroshi, Joyashiki, Eri, Hoshino, Maiko, Watanabe, Tomoyuki, Kinosaki, Masahiko, Nishimura, Yoshikazu, Esaki, Tohru, Ogawa, Kotaro, Miyake, Taiji, Arai, Shinichi, Shimizu, Masaru, Kitamura, Hidetomo, Sato, Haruhiko, Kawabe, Yoshiki

“…Parathyroid hormone (PTH) is essential for calcium homeostasis and its action is mediated by the PTH type 1 receptor (PTHR1), a class B G-protein-coupled…”
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Bone Morphogenetic Protein 4 and Smad1 Mediate Extracellular Matrix Production in the Development of Diabetic Nephropathy by Matsubara, Takeshi, Araki, Makoto, Abe, Hideharu, Ueda, Otoya, Jishage, Kou-ichi, Mima, Akira, Goto, Chisato, Tominaga, Tatsuya, Kinosaki, Masahiko, Kishi, Seiji, Nagai, Kojiro, Iehara, Noriyuki, Fukushima, Naoshi, Kita, Toru, Arai, Hidenori, Doi, Toshio

“…Diabetic nephropathy is the leading cause of end-stage renal disease. It is pathologically characterized by the accumulation of extracellular matrix in the…”
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RANK Is the Essential Signaling Receptor for Osteoclast Differentiation Factor in Osteoclastogenesis by Nakagawa, Nobuaki, Kinosaki, Masahiko, Yamaguchi, Kyoji, Shima, Nobuyuki, Yasuda, Hisataka, Yano, Kazuki, Morinaga, Tomonori, Higashio, Kanji

“…Osteoclast differentiation factor (ODF) is a ligand for osteoclastogenesis-inhibitory factor/osteoprotegerin (OCIF/OPG), and mediates an essential signal for…”
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Osteoclast Differentiation Factor is a Ligand for Osteoprotegerin/Osteoclastogenesis-Inhibitory Factor and is Identical to TRANCE/RANKL by Yasuda, Hisataka, Shima, Nobuyuki, Nakagawa, Nobuaki, Yamaguchi, Kyoji, Kinosaki, Masahiko, Mochizuki, Shin-Ichi, Tomoyasu, Akihiro, Yano, Kazuki, Goto, Masaaki, Murakami, Akihiko, Tsuda, Eisuke, Morinaga, Tomonori, Higashio, Kanji, Udagawa, Nobuyuki, Takahashi, Naoyuki, Suda, Tatsuo

“…Osteoclasts, the multinucleated cells that resorb bone, develop from hematopoietic cells of monocyte/macrophage lineage. Osteoclast-like cells (OCLs) are…”
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Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis by MIZUNO, Atsuko, KANNO, Takeshi, YASUDA, Hisataka, HIGASHIO, Kanji, HOSHI, Masaki, SHIBATA, Osamu, YANO, Kazuki, FUJISE, Nobuaki, KINOSAKI, Masahiko, YAMAGUCHI, Kyoji, TSUDA, Eisuke, MURAKAMI, Akihiko

“…Osteoclast differentiation factor, ODF, also called RANKL, TRANCE, or OPGL, is a key molecule for osteoclast differentiation and activation, and is thought to…”
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Characterization of Structural Domains of Human Osteoclastogenesis Inhibitory Factor by Yamaguchi, K, Kinosaki, M, Goto, M, Kobayashi, F, Tsuda, E, Morinaga, T, Higashio, K

“…Osteoclastogenesis inhibitory factor (OCIF) is a heparin-binding secretory glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) family. OCIF…”
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Human Fibroblast Growth Factor-23 Mutants Suppress Na+-dependent Phosphate Co-transport Activity and 1α,25-Dihydroxyvitamin D3 Production by Saito, Hitoshi, Kusano, Kenichiro, Kinosaki, Masahiko, Ito, Hirotaka, Hirata, Michinori, Segawa, Hiroko, Miyamoto, Ken-ichi, Fukushima, Naoshi

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Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction by Kobayashi, K, Takahashi, N, Jimi, E, Udagawa, N, Takami, M, Kotake, S, Nakagawa, N, Kinosaki, M, Yamaguchi, K, Shima, N, Yasuda, H, Morinaga, T, Higashio, K, Martin, T J, Suda, T

“…Osteoclast differentiation factor (ODF, also called RANKL/TRANCE/OPGL) stimulates the differentiation of osteoclast progenitors of the monocyte/macrophage…”
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Osteoclast Differentiation Factor Mediates an Essential Signal for Bone Resorption Induced by 1α,25-Dihydroxyvitamin D3, Prostaglandin E2, or Parathyroid Hormone in the Microenvironment of Bone by Tsukii, Katsuyoshi, Shima, Nobuyuki, Mochizuki, Shin-ichi, Yamaguchi, Kyoji, Kinosaki, Masahiko, Yano, Kazuki, Shibata, Osamu, Udagawa, Nobuyuki, Yasuda, Hiroshi, Suda, Tatsuo, Higashio, Kanji

“…Osteoclast differentiation factor (ODF), a ligand for osteoprotegerin (OPG)/osteoclastogenesis-inhibitory factor (OCIF), induces osteoclast-like cell…”
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Intracellular Localization of UDP-Glucuronosyltransferase Expressed from the Transfected cDNA in Cultured Cells by Kinosaki, Masahiko, Masuko, Takashi, Sogawa, Kazuhiro, Iyanagi, Takashi, Yamamoto, Tadashi, Hashimoto, Yoshiyuki, Fujii-Kuriyama, Yoshiaki

“…Liver UDP-glucuronosyltransferase (UDPGT) is localized in the endoplasmic reticulum (ER), with its catalytic domain exposed to the lumenal side of the membrane…”
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Osteoclastogenesis Inhibitory Factor Suppresses Osteoclast Survival by Interfering in the Interaction of Stromal Cells with Osteoclast by Akatsu, Takuhiko, Murakami, Takehiko, Nishikawa, Miyuki, Ono, Katsuhiro, Shinomiya, Nariyoshi, Tsuda, Eisuke, Mochizuki, Shin-Ichi, Yamaguchi, Kyoji, Kinosaki, Masahiko, Higashio, Kanji, Yamamoto, Michiko, Motoyoshi, Kazuo, Nagata, Naokazu

“…Osteoclastogenesis inhibitory factor (OCIF) was originally identified as a factor inhibiting osteoclast (OC) formation. The number of OC in rats treated with…”
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Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production by Saito, Hitoshi, Kusano, Kenichiro, Kinosaki, Masahiko, Ito, Hirotaka, Hirata, Michinori, Segawa, Hiroko, Miyamoto, Ken-Ichi, Fukushima, Naoshi

“…The human fibroblast growth factor 23 (hFGF23) and its autosomal dominant hypophosphatemic rickets (ADHR) mutant genes were incorporated into animals by naked…”
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Human Fibroblast Growth Factor-23 Mutants Suppress Na+-dependent Phosphate Co-transport Activity and 1α,25-Dihydroxyvitamin D3 Production by Hitoshi Saito, Kenichiro Kusano, Masahiko Kinosaki, Hirotaka Ito, Michinori Hirata, Hiroko Segawa, Ken-ichi Miyamoto, Naoshi Fukushima

“…The human fibroblast growth factor 23 (hFGF23) and its autosomal dominant hypophosphatemic rickets (ADHR) mutant genes were incorporated into animals by naked…”
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A Mutant of Deleted Variant of Hepatocyte Growth Factor (dHGF) with Alanine Substitution in the N-Terminal Basic Region Has Higher Activityin Vivo by Kinosaki, Masahiko, Yamaguchi, Kyoji, Yamashita, Yasushi, Uematsu, Yasuhiro, Aihara, Hiromi, Masunaga, Hiroaki, Morinaga, Tomonori, Higashio, Kanji

“…In a previous study, we generated a mutant of dHGF (deleted variant of hepatocyte growth factor), termed #2, with higher specific activity than dHGF in assays…”
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Analysis of deleted variant of hepatocyte growth factor by alanine scanning mutagenesis: identification of residues essential for its biological function and generation of mutants with enhanced mitogenic activity on rat hepatocytes by Kinosaki, Masahiko, Yamaguchi, Kyoji, Murakami, Akihiko, Morinaga, Tomonori, Ueda, Masatsugu, Higashio, Kanji

“…To understand the structure-function relationship of hepatocyte growth factor (HGF) in more detail, we analyzed one of the other forms of HGF, deleted variant…”
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A mutant of deleted variant of hepatocyte growth factor (dHGF) with alanine substitution in the N-terminal basic region has higher activity in vivo by Kinosaki, M, Yamaguchi, K, Yamashita, Y, Uematsu, Y, Aihara, H, Masunaga, H, Morinaga, T, Higashio, K

“…In a previous study, we generated a mutant of dHGF (deleted variant of hepatocyte growth factor), termed #2, with higher specific activity than dHGF in assays…”
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Identification of heparin-binding stretches of a naturally occurring deleted variant of hepatocyte growth factor (dHGF) by Kinosaki, Masahiko, Yamaguchi, Kyoji, Murakami, Akihiko, Ueda, Masatugu, Morinaga, Tomonori, Higashio, Kanji

“…A deleted variant of hepatocyte growth factor (dHGF) is a naturally occurring major variant of HGF, which lacks five consecutive amino acid residues in the…”
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A novel species of cytochrome P-450 (P-450ib) specific for the small intestine of rabbits. cDNA cloning and its expression in COS cells by KIKUTA, Y, SOGAWA, K, HANIU, M, KINOSAKI, M, KUSUNOSE, E, NOJIMA, Y, YAMAMOTO, S, ICHIHARA, K, KUSUNOSE, M, FUJII-KURIYAMA, Y

“…We have isolated a cDNA clone for a P-450, designated P-450ib (Ichihara, K., Kusunose, E., Kaku, M., Yamamoto, S., and Kusunose, M. (1985) Biochim. Biophys…”
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cDNA cloning and expression of the mRNA for cytochrome P‐450kd which shows a fatty acid ω‐hydroxylating activity by YOKOTANI, Noboru, KUSUNOSE, Emi, SOGAWA, Kazuhiro, KAWASHIMA, Hidenori, KINOSAKI, Masahiko, KUSUNOSE, Masamichi, FUJII‐KURIYAMA, Yoshiaki

“…We have recently purified three distinct forms of fatty acid ω‐hydroxylase cytochrome P‐450 (P‐450), designated P‐450ka‐1, P‐450ka‐2 and P‐450kd, from rabbit…”
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cDNA cloning and expression of the mRNA for cytochrome P ‐450 kd which shows a fatty acid ω‐hydroxylating activity by YOKOTANI, Noboru, KUSUNOSE, Emi, SOGAWA, Kazuhiro, KAWASHIMA, Hidenori, KINOSAKI, Masahiko, KUSUNOSE, Masamichi, FUJII‐KURIYAMA, Yoshiaki

“…We have recently purified three distinct forms of fatty acid ω‐hydroxylase cytochrome P ‐450 ( P ‐450), designated P ‐450 ka‐1 , P ‐450 ka‐2 and P ‐450 kd ,…”
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