Search Results - "Kinoh, H"

Selective intracellular delivery of proteasome inhibitors through pH-sensitive polymeric micelles directed to efficient antitumor therapy by Quader, S, Cabral, H, Mochida, Y, Ishii, T, Liu, X, Toh, K, Kinoh, H, Miura, Y, Nishiyama, N, Kataoka, K

“…The ubiquitin-proteasome system is central in the regulation of cellular proteins controlling cell cycle progression and apoptosis, drawing much interest for…”
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Improvement of cardiac fibrosis in dystrophic mice by rAAV9-mediated microdystrophin transduction by Shin, J-H, Nitahara-Kasahara, Y, Hayashita-Kinoh, H, Ohshima-Hosoyama, S, Kinoshita, K, Chiyo, T, Okada, H, Okada, T, Takeda, S

“…Duchenne muscular dystrophy (DMD) is the most common form of the progressive muscular dystrophies characterized by defects of the dystrophin gene. Although…”
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Generation of optimized and urokinase-targeted oncolytic Sendai virus vectors applicable for various human malignancies by Kinoh, H, Inoue, M, Komaru, A, Ueda, Y, Hasegawa, M, Yonemitsu, Y

“…We previously reported the development of a prototype ‘oncolytic Sendai virus (SeV) vector’ formed by introducing two major genomic modifications to the…”
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Absence of mechanical allodynia and Aβ-fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinase by Komori, Kiyoshi, Nonaka, Takahiro, Okada, Akiko, Kinoh, Hiroaki, Hayashita-Kinoh, Hiromi, Yoshida, Nobuaki, Yana, Ikuo, Seiki, Motoharu

“…Matrix metalloproteinases (MMPs) are a family of endopeptidases that degrade extracellular matrix components. Membrane-type 5 MMP (MT5-MMP/MMP-24) was…”
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Generation of a recombinant Sendai virus that is selectively activated and lyses human tumor cells expressing matrix metalloproteinases by KINOH, H, INOUE, M, WASHIZAWA, K, YAMAMOTO, T, FUJIKAWA, S, TOKUSUMI, Y, IIDA, A, NAGAI, Y, HASEGAWA, M

“…Malignant tumor cells often express matrix metalloproteinases (MMPs) at a high level to enable their dissemination and metastasis. Sendai virus (SeV), a…”
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Polymeric Osteopontin Employs Integrin α9β1 as a Receptor and Attracts Neutrophils by Presenting a de Novo Binding Site by Nishimichi, Norihisa, Higashikawa, Fumiko, Kinoh, Hiromi H., Tateishi, Yoshiko, Matsuda, Haruo, Yokosaki, Yasuyuki

“…Osteopontin (OPN) is a cytokine and ligand for multiple members of the integrin family. OPN undergoes the in vivo polymerization catalyzed by cross-linking…”
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Membrane-Type 1 Matrix Metalloproteinase Cleaves CD44 and Promotes Cell Migration by Kajita, Masahiro, Itoh, Yoshifumi, Chiba, Tadashige, Mori, Hidetoshi, Okada, Akiko, Kinoh, Hiroaki, Seiki, Motoharu

“…Migratory cells including invasive tumor cells frequently express CD44, a major receptor for hyaluronan and membrane-type 1 matrix metalloproteinase (MT1-MMP)…”
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Scalable purification of adeno-associated virus serotype 1 (AAV1) and AAV8 vectors, using dual ion-exchange adsorptive membranes by Okada, Takashi, Nonaka-Sarukawa, Mutsuko, Uchibori, Ryosuke, Kinoshita, Kazue, Hayashita-Kinoh, Hiromi, Nitahara-Kasahara, Yuko, Takeda, Shin'ichi, Ozawa, Keiya

“…In vivo gene transduction with adeno-associated virus (AAV)-based vectors depends on laborious procedures for the production of high-titer vector stocks…”
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Membrane-type 5 matrix metalloproteinase is expressed in differentiated neurons and regulates axonal growth by HAYASHITA-KINOH, Hiromi, KINOH, Hiroaki, OKADA, Akiko, KOMORI, Kiyoshi, ITOH, Yoshifumi, CHIBA, Tadashige, KAJITA, Masahiro, YANA, Ikuo, SEIKI, Motoharu

“…Expression of membrane-type (MT) 5 matrix metalloproteinase (MMP) in the mouse brain was examined. MT5-MMP was expressed in the cerebrum in embryos, but it…”
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Down-regulation of α-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson’s disease rat model by Hayashita-Kinoh, Hiromi, Yamada, Masanori, Yokota, Takanori, Mizuno, Yoshikuni, Mochizuki, Hideki

“…Fibrillization and aggregation of α-synuclein may play a critical role in neurodegenerative diseases like Parkinson’s diseases. Adeno-associated virus (AAV)…”
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New cancer therapy using genetically-engineered oncolytic Sendai virus vector by Kinoh, Hiroaki, Inoue, Makoto

“…We have developed a new type of Sendai virus-(SeV) based gene transfer vectors for cancer therapy. The matrix gene-, indispensable for particle formation,…”
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Membrane Type 4 Matrix Metalloproteinase (MT4-MMP, MMP-17) Is a Glycosylphosphatidylinositol-anchored Proteinase by Itoh, Y, Kajita, M, Kinoh, H, Mori, H, Okada, A, Seiki, M

“…Among the five membrane-type matrix metalloproteinases (MT-MMPs), MT1-, MT2-, MT3-, and MT5-MMPs have about a 20-amino acid cytoplasmic tail following the…”
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Immunostimulatory virotherapy using recombinant Sendai virus as a new cancer therapeutic regimen by Yonemitsu, Yoshikazu, Ueda, Yasuji, Kinoh, Hiroaki, Hasegawa, Mamoru

“…The utility of recombinant Sendai virus (rSeV) has been considerably examined over the last decade as a potent gene transfer candidate in a cytoplasmic gene…”
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Polymeric Osteopontin Employs Integrin α9β1 as a Receptor and Attracts Neutrophils by Presenting a de Novo Binding Site by Norihisa Nishimichi, Fumiko Higashikawa, Hiromi H. Kinoh, Yoshiko Tateishi, Haruo Matsuda, Yasuyuki Yokosaki

“…Osteopontin (OPN) is a cytokine and ligand for multiple members of the integrin family. OPN undergoes the in vivo polymerization catalyzed by cross-linking…”
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RIG-I helicase-independent pathway in sendai virus-activated dendritic cells is critical for preventing lung metastasis of AT6.3 pProstate cancer by Kato, T, Ueda, Y, Kinoh, H, Yoneyama, Y, Matsunaga, A, Komaru, A, Harada, Y, Suzuki, H, Komiya, A, Shibata, S, Hasegawa, M, Hayashi, H, Ichikawa, T, Yonemitsu, Y

“…We recently demonstrated highly efficient antitumor immunity against dermal tumors of B16F10 murine melanoma with the use of dendritic cells (DCs) activated by…”
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Immunostimulatory virotherapy using recombinant Sendai virus as a new cancer therapeutic regimen by Yonemitsu, Yoshikazu, Ueda, Yasuji, Kinoh, Hiroaki, Hasegawa, Mamoru

“…The utility of recombinant Sendai virus (rSeV) has been considerably examined over the last decade as a potent gene transfer candidate in a cytoplasmic gene…”
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Nucleotide sequence of the proton ATPase beta-subunit homologue of the sea urchin Hemicentrotus pulcherrimus by Satoh, Y, Shimizu, T, Sendai, Y, Kinoh, H, Suzuki, N

“…A cDNA with 2.3 kb encoding F1-F0 ATP synthase (proton ATPase) beta-subunit homologue was isolated from a testis cDNA library of the sea urchin, Hemicentrotus…”
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MT-MMP, the cell surface activator of proMMP-2 (pro-gelatinase A), is expressed with its substrate in mouse tissue during embryogenesis by Kinoh, H, Sato, H, Tsunezuka, Y, Takino, T, Kawashima, A, Okada, Y, Seiki, M

“…Matrix metalloproteinases (MMPs), which degrade the components of the extracellular matrix, are key enzymes involved in the tissue remodeling of multicellular…”
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Recombinant Sendai Virus Vector Induces Complete Remission of Established Brain Tumors through Efficient Interleukin-2 Gene Transfer in Vaccinated Rats by IWADATE, Yasuo, INOUE, Makoto, SAEGUSA, Takashi, TOKUSUMI, Yumiko, KINOH, Hiroaki, HASEGAWA, Mamoru, TAGAWA, Masatoshi, YAMAURA, Akira, SHIMADA, Hideaki

“…Purpose: Sendai virus (SeV), a murine parainfluenza virus type I, replicates independent of cellular genome and directs high-level gene expressions when used…”
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Expression of membrane-type matrix metalloproteinase 1 (MT1-MMP) in tumor cells enhances pulmonary metastasis in an experimental metastasis assay by TSUNEZUKA, Y, KINOH, H, TAKINO, T, WATANABE, Y, OKADA, Y, SHINAGAWA, A, SATO, H, SEIKI, M

“…Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a member of the recently identified unique membrane-type subgroup in the matrix metalloproteinase (MMP)…”
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