Search Results - "Kinnunen, Paavo K.J."

Oxidized Phosphatidylcholines Promote Phase Separation of Cholesterol-Sphingomyelin Domains by Volinsky, Roman, Paananen, Riku, Kinnunen, Paavo K.J.

“…Lipid lateral segregation in the plasma membrane is believed to play an important role in cell physiology. Sphingomyelin (SM) and cholesterol (Chol)-enriched…”
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Oxidized Phosphatidylcholines Facilitate Phospholipid Flip-Flop in Liposomes by Volinsky, Roman, Cwiklik, Lukasz, Jurkiewicz, Piotr, Hof, Martin, Jungwirth, Pavel, Kinnunen, Paavo K.J.

“…Lipid asymmetry is a ubiquitous property of the lipid bilayers in cellular membranes and its maintenance and loss play important roles in cell physiology, such…”
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Molecular Mechanisms of Membrane Deformation by I-BAR Domain Proteins by Saarikangas, Juha, Zhao, Hongxia, Pykäläinen, Anette, Laurinmäki, Pasi, Mattila, Pieta K., Kinnunen, Paavo K.J., Butcher, Sarah J., Lappalainen, Pekka

“…Generation of membrane curvature is critical for the formation of plasma membrane protrusions and invaginations and for shaping intracellular organelles. Among…”
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Protein-oxidized phospholipid interactions in cellular signaling for cell death: From biophysics to clinical correlations by Kinnunen, Paavo K.J., Kaarniranta, Kai, Mahalka, Ajay K.

“…Oxidative stress is associated with several major ailments. However, it is only recently that the developments in our molecular level understanding of the…”
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The role of lipid–protein interactions in amyloid-type protein fibril formation by Gorbenko, Galyna P., Kinnunen, Paavo K.J.

“…Structural transition of polypeptide chains into the β-sheet state followed by amyloid fibril formation is the key characteristic of a number of the so-called…”
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Human heat shock protein 70 (Hsp70) as a peripheral membrane protein by Mahalka, Ajay K., Kirkegaard, Thomas, Jukola, Laura T.I., Jäättelä, Marja, Kinnunen, Paavo K.J.

“…While a significant fraction of heat shock protein 70 (Hsp70) is membrane associated in lysosomes, mitochondria, and the outer surface of cancer cells, the…”
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Antimicrobial Peptides Temporins B and L Induce Formation of Tubular Lipid Protrusions from Supported Phospholipid Bilayers by Domanov, Yegor A., Kinnunen, Paavo K.J.

“…The binding of the antimicrobial peptides temporins B and L to supported lipid bilayer (SLB) model membranes composed of phosphatidylcholine and…”
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Lipid microdomains in dimyristoylphosphatidylcholine–ceramide liposomes by Holopainen, Juha M, Lehtonen, Jukka Y.A, Kinnunen, Paavo K.J

“…Binary membranes composed of dimyristoylphosphatidylcholine (DMPC) and natural ceramide (up to a mole fraction X cer=0.25) were investigated by measuring the…”
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Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology by Kirkegaard, Thomas, Mahalka, Ajay K, Moilanen, Irina, Sandhoff, Konrad, Zylicz, Alicja, Kinnunen, Paavo K. J, Olsen, Ole Dines, Jäättelä, Marja, Nylandsted, Jesper, Petersen, Nikolaj H. T, Roth, Anke G, Knudsen, Jens, Arenz, Christoph

“…Heat shock protein 70 (Hsp70) is an evolutionarily highly conserved molecular chaperone that promotes the survival of stressed cells by inhibiting lysosomal…”
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Phospholipid lateral diffusion in phosphatidylcholine-sphingomyelin-cholesterol monolayers; Effects of oxidatively truncated phosphatidylcholines by Parkkila, Petteri, Štefl, Martin, Olżyńska, Agnieszka, Hof, Martin, Kinnunen, Paavo K.J.

“…Oxidative stress is involved in a number of pathological conditions and the generated oxidatively modified lipids influence membrane properties and functions,…”
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Gravimetric determination of phospholipid concentration by Tejera-Garcia, Roberto, Connell, Lisa, Shaw, Walter A., Kinnunen, Paavo K.J.

“…► A detailed procedure for the gravimetric analysis of the concentrations of lipid stock solutions is presented. ► The concentrations of a number of…”
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Principles of rational design of thermally targeted liposomes for local drug delivery by Tejera-Garcia, Roberto, PhD, Parkkila, Petteri, BSc, Zamotin, Vladimir, PhD, Kinnunen, Paavo K.J., PhD

“…Abstract Drug release from 1,2-dipalmitoyl- sn -glycero-3-phosphocholine (DPPC) liposomes occurs close to the main transition temperature Tm = 41 °C. The exact…”
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Vectorial Budding of Vesicles by Asymmetrical Enzymatic Formation of Ceramide in Giant Liposomes by Holopainen, Juha M., Angelova, Miglena I., Kinnunen, Paavo K.J.

“…Sphingomyelin is an abundant component of eukaryotic membranes. A specific enzyme, sphingomyelinase can convert this lipid to ceramide, a central second…”
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Temporin L: antimicrobial, haemolytic and cytotoxic activities, and effects on membrane permeabilization in lipid vesicles by Rinaldi, Andrea C, Mangoni, Maria Luisa, Rufo, Anna, Luzi, Carla, Barra, Donatella, Zhao, Hongxia, Kinnunen, Paavo K J, Bozzi, Argante, Di Giulio, Antonio, Simmaco, Maurizio

“…The temporins are a family of small, linear antibiotic peptides with intriguing biological properties. We investigated the antibacterial, haemolytic and…”
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Activation of phospholipase A2 by Hsp70 in vitro by Mahalka, Ajay K., Code, Christian, Rezaijahromi, Behnam, Kirkegaard, Thomas, Jäättelä, Marja, Kinnunen, Paavo K.J.

“…We recently suggested a novel mechanism for the activation of phospholipase A2 (PLA2), with a (catalytically) highly active oligomeric state, which…”
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Evidence for the Lack of a Specific Interaction between Cholesterol and Sphingomyelin by Holopainen, Juha M., Metso, Antti J., Mattila, Juha-Pekka, Jutila, Arimatti, Kinnunen, Paavo K.J.

“…The putative specific interaction and complex formation by sphingomyelin and cholesterol was investigated. Accordingly, low contents (1 mol % each) of…”
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Comparison of the Effects of Surface Tension and Osmotic Pressure on the Interfacial Hydration of a Fluid Phospholipid Bilayer by Söderlund, Tim, Alakoskela, Juha-Matti I., Pakkanen, Antti L., Kinnunen, Paavo K.J.

“…The effects of three so-called kosmotropic solutes, namely, betaine, sucrose, and choline chloride on 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine large…”
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Interlamellar Coupling of Phospholipid Bilayers in Liposomes: An Emergent Property of Lipid Rearrangement by Parry, Mikko J, Hagen, Morten, Mouritsen, Ole G, Kinnunen, Paavo K.J, Alakoskela, Juha-Matti I

“…The thermal phase behaviors of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) large unilamellar vesicles (LUVs) and multilamellar vesicles (MLVs) were…”
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Simple coating of capillaries with anionic liposomes in capillary electrophoresis by Hautala, Jari T, Lindén, Maria V, Wiedmer, Susanne K, Ryhänen, Samppa J, Säily, Matti J, Kinnunen, Paavo K.J, Riekkola, Marja-Liisa

“…A new and relatively simple method was developed for coating of capillaries in electrophoresis with liposomes. The liposomes, with a diameter of about 100 nm,…”
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On the molecular-level mechanisms of peripheral protein-membrane interactions induced by lipids forming inverted non-lamellar phases by Kinnunen, Paavo K.J.

“…Protein kinase C (PKC) represents at present the paradigm for enzymes activated by lipids forming inverted non-lamellar phases, hexagonal phase H II, in…”
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