Search Results - "Kinnunen, Paavo K. J."

Oxidized phosphatidylcholines in membrane‐level cellular signaling: from biophysics to physiology and molecular pathology by Volinsky, Roman, Kinnunen, Paavo K. J.

“…The oxidation of lipids has been shown to impact virtually all cellular processes. The paradigm has been that this involvement is due to interference with the…”
Get full text

Acyl Chain Disorder and Azelaoyl Orientation in Lipid Membranes Containing Oxidized Lipids by Mendes Ferreira, Tiago, Sood, Rohit, Bärenwald, Ruth, Carlström, Göran, Topgaard, Daniel, Saalwächter, Kay, Kinnunen, Paavo K. J, Ollila, O. H. Samuli

“…Oxidized phospholipids occur naturally in conditions of oxidative stress and have been suggested to play an important role in a number of pathological…”
Get full text

Formation of Amyloid Fibers Triggered by Phosphatidylserine-Containing Membranes by Zhao, Hongxia, Tuominen, Esa K. J, Kinnunen, Paavo K. J

“…Protein misfolding has been shown to be the direct cause of a number of highly devastating diseases such as Alzheimer's disease, Parkinson's disease, and…”
Get full text

Biocompatibility of Liposome Nanocarriers in the Rat Inner Ear After Intratympanic Administration by Zou, Jing, Feng, Hao, Sood, Rohit, Kinnunen, Paavo K. J., Pyykko, Ilmari

“…Liposome nanocarriers (LPNs) are potentially the future of inner ear therapy due to their high drug loading capacity and efficient uptake in the inner ear…”
Get full text

Pathway and morphological transformation of liposome nanocarriers after release from a novel sustained inner-ear delivery system by Zou, Jing, Sood, Rohit, Zhang, Ya, Kinnunen, Paavo K J, Pyykkö, Ilmari

“…To validate a novel sustained delivery system of liposome nanocarriers for inner-ear therapy and to investigate the transport pathway for their delivery…”
Get more information

Screening for the Drug-Phospholipid Interaction: Correlation to Phospholipidosis by Alakoskela, Juha-Matti, Vitovič, Pavol, Kinnunen, Paavo K. J.

“…Phospholipid bilayers represent a complex, anisotropic environment fundamentally different from bulk oil or octanol, for instance. Even “simple” drug…”
Get full text

1-Palmitoyl-2-(9′-oxononanoyl)-sn-glycero-3-phosphocholine, an Oxidized Phospholipid, Accelerates Finnish Type Familial Gelsolin Amyloidosis in Vitro by Mahalka, Ajay K, Maury, C. Peter J, Kinnunen, Paavo K. J

“…Finnish type familial amyloidosis (FAF) is a neurodegenerative disease, which involves the deposition of D187N or -Y mutant gelsolin fragments as amyloid in…”
Get full text

High-Affinity Small Molecule−Phospholipid Complex Formation: Binding of Siramesine to Phosphatidic Acid by Parry, Mikko J, Alakoskela, Juha-Matti I, Khandelia, Himanshu, Kumar, Subramanian Arun, Jäättelä, Marja, Mahalka, Ajay K, Kinnunen, Paavo K. J

“…Siramesine (SRM) is a σ−2 receptor agonist which has been recently shown to inhibit growth of cancer cells. Fluorescence spectroscopy experiments revealed two…”
Get full text

Enantiospecific Interactions between Cholesterol and Phospholipids by Alakoskela, Juha-Matti, Sabatini, Karen, Jiang, Xin, Laitala, Venla, Covey, Douglas F, Kinnunen, Paavo K. J

“…The effects of cholesterol on various membrane proteins have received considerable attention. An important question regarding each of these effects is whether…”
Get full text

Observation of Topical Catalysis by Sphingomyelinase Coupled To Microspheres by Nurminen, Tuula A, Holopainen, Juha M, Zhao, Hongxia, Kinnunen, Paavo K. J

“…Sphingomyelinase, SMase (EC 3.1.4.12), was coupled onto amino-derivatized acrylate microspheres and was shown to retain its catalytic activity. The immobilized…”
Get full text

Influence of the Spacer of Cationic Gemini Amphiphiles on the Hydration of Lipoplexes by Luciani, Paola, Bombelli, Cecilia, Colone, Marisa, Giansanti, Luisa, Ryhänen, Samppa J, Säily, V. Matti J, Mancini, Giovanna, Kinnunen, Paavo K. J

“…The impact of the length of gemini surfactant spacer on complexation and condensation of calf thymus DNA by cationic mixed phospholipid/gemini liposomes was…”
Get full text

Modulation of the Activity of Secretory Phospholipase A2 by Antimicrobial Peptides by Zhao, Hongxia, Kinnunen, Paavo K J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Characteristics of Fibers Formed by Cytochrome c and Induced by Anionic Phospholipids by Alakoskela, Juha-Matti, Jutila, Arimatti, Simonsen, Adam C, Pirneskoski, Jussi, Pyhäjoki, Sinikka, Turunen, Raija, Marttila, Sani, Mouritsen, Ole G, Goormaghtigh, Erik, Kinnunen, Paavo K. J

“…Recent publications described the formation of millimeter-length fibers by diverse lipid-binding proteins (e.g., histone H1, cytochrome c, indolicidin, and…”
Get full text

Interfacial Behavior of Cholesterol, Ergosterol, and Lanosterol in Mixtures with DPPC and DMPC by Sabatini, Karen, Mattila, Juha-Pekka, Kinnunen, Paavo K.J.

“…Binary mixtures of cholesterol, ergosterol, and lanosterol with phosphatidylcholines differing in the length of the saturated acyl chains, viz 1,2-dipalmitoyl-…”
Get full text

Oxidized Phosphatidylcholines Facilitate Phospholipid Flip-Flop in Liposomes by Volinsky, Roman, Cwiklik, Lukasz, Jurkiewicz, Piotr, Hof, Martin, Jungwirth, Pavel, Kinnunen, Paavo K.J.

“…Lipid asymmetry is a ubiquitous property of the lipid bilayers in cellular membranes and its maintenance and loss play important roles in cell physiology, such…”
Get full text

Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology by Kirkegaard, Thomas, Mahalka, Ajay K, Moilanen, Irina, Sandhoff, Konrad, Zylicz, Alicja, Kinnunen, Paavo K. J, Olsen, Ole Dines, Jäättelä, Marja, Nylandsted, Jesper, Petersen, Nikolaj H. T, Roth, Anke G, Knudsen, Jens, Arenz, Christoph

“…Heat shock protein 70 (Hsp70) is an evolutionarily highly conserved molecular chaperone that promotes the survival of stressed cells by inhibiting lysosomal…”
Get full text

Oxidized Phosphatidylcholines Promote Phase Separation of Cholesterol-Sphingomyelin Domains by Volinsky, Roman, Paananen, Riku, Kinnunen, Paavo K.J.

“…Lipid lateral segregation in the plasma membrane is believed to play an important role in cell physiology. Sphingomyelin (SM) and cholesterol (Chol)-enriched…”
Get full text

Increasing Surface Charge Density Induces Interdigitation in Vesicles of Cationic Amphiphile and Phosphatidylcholine by Ryhänen, Samppa J, Alakoskela, Juha-Matti I, Kinnunen, Paavo K. J

“…Binary vesicles of cationic lipid dihexadecyldimethylammoniumbromide (DHAB) and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) were examined by…”
Get full text

Assessment of Drug−Lipid Complex Formation by a High-Throughput Langmuir-Balance and Correlation to Phospholipidosis by Vitovič, Pavol, Alakoskela, Juha-Matti, Kinnunen, Paavo K. J

“…Phospholipidosis, the accumulation of phospholipids in cells, is a relatively frequent side effect of cationic amphiphilic drugs. In response to the industry…”
Get full text

Enantiomers of neuroactive steroids support a specific interaction with the GABA-C receptor as the mechanism of steroid action by Li, Wenjun, Covey, Douglas F, Alakoskela, Juha-Matti, Kinnunen, Paavo K J, Steinbach, Joe Henry

“…Neuroactive steroids can either potentiate or inhibit a variety of membrane channels. Most studies have suggested that the effects are mediated by specific…”
Get more information