Search Results - "Kinloch, Andrew"

In Situ Humoral Immunity to Vimentin in HLA-DRB103 + Patients With Pulmonary Sarcoidosis by Kinloch, Andrew J, Kaiser, Ylva, Wolfgeher, Don, Ai, Junting, Eklund, Anders, Clark, Marcus R, Grunewald, Johan

“…Vimentin has been implicated in pulmonary sarcoidosis as a T-cell autoantigen, particularly in the context of , the Vα2.3/Vβ22 T-cell receptor (TCR), and…”
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Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis by Wegner, Natalia, Lundberg, Karin, Kinloch, Andrew, Fisher, Benjamin, Malmström, Vivianne, Feldmann, Marc, Venables, Patrick J

“…Rheumatoid arthritis (RA) is now clearly a true autoimmune disease with accumulating evidence of pathogenic disease-specific autoimmunity to citrullinated…”
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Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection by Asano, Yuta, Daccache, Joe, Jain, Dharmendra, Ko, Kichul, Kinloch, Andrew, Veselits, Margaret, Wolfgeher, Donald, Chang, Anthony, Josephson, Michelle, Cunningham, Patrick, Tambur, Anat, Khan, Aly A., Pillai, Shiv, Chong, Anita S., Clark, Marcus R.

“…Intrarenal B cells in human renal allografts indicate transplant recipients with a poor prognosis, but how these cells contribute to rejection is unclear. Here…”
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Vimentin Is a Dominant Target of In Situ Humoral Immunity in Human Lupus Tubulointerstitial Nephritis by Kinloch, Andrew J., Chang, Anthony, Ko, Kichul, Henry Dunand, Carole J., Henderson, Scott, Maienschein‐Cline, Mark, Kaverina, Natalya, Rovin, Brad H., Salgado Ferrer, Marlene, Wolfgeher, Don, Liarski, Vladimir, Haddon, D. James, Utz, Paul J., Wilson, Patrick C., Clark, Marcus R.

“…Objective In lupus nephritis (LN), severe tubulointerstitial inflammation (TII) predicts progression to renal failure. Severe TII is associated with tertiary…”
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A Critical Role for LTA₄H in Limiting Chronic Pulmonary Neutrophilic Inflammation by Snelgrove, Robert J., Jackson, Patricia L., Hardison, Matthew T., Noerager, Brett D., Kinloch, Andrew, Gaggar, Amit, Shastry, Suresh, Rowe, Steven M., Shim, Yun M., Hussell, Tracy, Blalock, J. Edwin

“…Leukotriene A₄ hydrolase (LTA₄H) is a proinflammatory enzyme that generates the inflammatory mediator leukotriene B₄ (LTB₄). LTA₄H also possesses…”
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Corrigendum to “Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu” [J. Autoimmun. 113 (2020) 102469] by Zhang, Dongdong, Kinloch, Andrew J., Srinath, Abhinav, Shenkar, Robert, Girard, Romuald, Lightle, Rhonda, Moore, Thomas, Koskimäki, Janne, Mohsin, Azam, Carrión-Penagos, Julián, Romanos, Sharbel, Shen, Le, Clark, Marcus R., Shi, Changbin, Awad, Issam A.

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Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation by Kinloch, Andrew J, Asano, Yuta, Mohsin, Azam, Henry, Carole, Abraham, Rebecca, Chang, Anthony, Labno, Christine, Wilson, Patrick C, Clark, Marcus R

“…In human lupus nephritis, tubulointerstitial inflammation (TII) is associated with expansion of B cells expressing anti-vimentin antibodies (AVAs). The…”
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Anti-vimentin antibodies: a unique antibody class associated with therapy-resistant lupus nephritis by Kinloch, Andrew J, Cascino, Matthew D, Dai, Jian, Bermea, Rene S, Ko, Kichul, Vesselits, Margaret, Dragone, Leonard L, Mor Vaknin, Nirit, Legendre, Maureen, Markovitz, David M, Okoreeh, Michael K, Townsend, Michael J, Clark, Marcus R

“…Background Tubulointerstitial inflammation (TII) in lupus nephritis is associated with a worse prognosis. Vimentin, a filamental antigen, is commonly targeted…”
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Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu by Zhang, Dongdong, Kinloch, Andrew J., Srinath, Abhinav, Shenkar, Robert, Girard, Romuald, Lightle, Rhonda, Moore, Thomas, Koskimäki, Janne, Mohsin, Azam, Carrión-Penagos, Julián, Romanos, Sharbel, Shen, Le, Clark, Marcus R., Shi, Changbin, Awad, Issam A.

“…Previous studies have reported robust inflammatory cell infiltration, synthesis of IgG, B-cell clonal expansion, deposition of immune complexes and complement…”
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Citrullination of autoantigens: Upstream of TNFα in the pathogenesis of rheumatoid arthritis by Quirke, Anne-Marie, Fisher, Benjamin A.C., Kinloch, Andrew J., Venables, Patrick J.

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by synovial inflammation and destruction of joints. Over 20years ago, tumour necrosis…”
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Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis by Clark, Marcus R, Chang, Anthony, Ko, Kichul, Henry Dunand, Carole J, Henderson, Scott, Brandt, Dan, Kaverina, Natalya, Liarski, Vladimir, Wilson, Patrick C, Kinloch, Andrew J

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Measurements of Mcl-1 protein dependencies using dimerization-specific antibodies as predictive biomarkers for BH-3 mimetic class therapies in AML by Cardone, Michael H., Kinloch, Andrew, Canakci, Mine, Ge, Jingping

“…Abstract only e19505 Background: The anti-apoptotic Bcl-2 family proteins facilitate pro-survival and resistance to anti-cancer therapies. Measuring the…”
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Immunization with Porphyromonas gingivalis enolase induces autoimmunity to mammalian α‐enolase and arthritis in DR4‐IE–transgenic mice by Kinloch, Andrew J., Alzabin, Saba, Brintnell, William, Wilson, Elizabeth, Barra, Lillian, Wegner, Natalia, Bell, David A., Cairns, Ewa, Venables, Patrick J.

“…Objective To examine the hypothesis that the subset of rheumatoid arthritis (RA) characterized by antibodies to citrullinated α‐enolase is mediated by…”
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Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis by Kinloch, Andrew, Lundberg, Karin, Wait, Robin, Wegner, Natalia, Lim, Ngee Han, Zendman, Albert J. W., Saxne, Tore, Malmstr, Vivianne, Venables, Patrick J.

“…Objective To examine synovial fluid as a site for generating citrullinated antigens, including the candidate autoantigen citrullinated α‐enolase, in rheumatoid…”
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Corrigendum to "Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu" J. Autoimmun. 113 (2020) 102469 by Zhang, Dongdong, Kinloch, Andrew J, Srinath, Abhinav, Shenkar, Robert, Girard, Romuald, Lightle, Rhonda, Moore, Thomas, Koskimäki, Janne, Mohsin, Azam, Carrión-Penagos, Julián, Romanos, Sharbel, Shen, Le, Clark, Marcus R, Shi, Changbin, Awad, Issam A

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Clinical applications of autoimmunity to citrullinated proteins in rheumatoid arthritis, from improving diagnostics to future therapies by Kinloch, Andrew J, Ng, Karen, Wright, Graham P

“…Rheumatoid arthritis (RA), although widely considered to be the most commonly occurring autoimmune disease, has only truly been substantiated as a distinct…”
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Abstract TMP120: Autoantigen(s) Trigger a Robust Immune Response in Cerebral Cavernous Malformations by Zhang, Dongdong, Srinath, Abhinav, Kinloch, Andrew J, Shenkar, Robert, Shen, Le, Koskimaki, Janne, Girard, Romuald, Lightle, Rhonda, Moore, Thomas, Cao, Ying, Penagos, Julian C, Romanos, Sharbel, Lyne, Sean, Shi, Changbin, Awad, Issam A

“…Abstract only Introduction: Previous studies have reported robust inflammatory cell infiltration, selective synthesis of IgG, B-cell clonal expansion, and…”
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Vimentin is a dominant target of in situ humoral immunity in human lupus tubulointerstitial nephritis (HUM1P.314) by Clark, Marcus, Chang, Anthony, Ko, Kichul, Liarski, Vladimir, Kinloch, Andrew

“…Abstract In lupus nephritis (LuN), severity of tubulointerstitial inflammation (TII) on renal biopsy predicts subsequent renal failure. In severe TII,…”
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Immune complex formation and in situ B-cell clonal expansion in human cerebral cavernous malformations by Shi, Changbin, Shenkar, Robert, Kinloch, Andrew, Henderson, Scott G, Shaaya, Mark, Chong, Anita S, Clark, Marcus R, Awad, Issam A

“…Abstract Cerebral cavernous malformations (CCMs) represent clusters of dilated vascular channels, predisposing to hemorrhagic stroke and seizures. They are…”
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Identification of citrullinated alpha-enolase as a candidate autoantigen in rheumatoid arthritis by Kinloch, Andrew, Tatzer, Verena, Wait, Robin, Peston, David, Lundberg, Karin, Donatien, Phillipe, Moyes, David, Taylor, Peter C, Venables, Patrick J

“…Antibodies against citrullinated proteins are highly specific for rheumatoid arthritis (RA), but little is understood about their citrullinated target…”
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