Search Results - "Kinkel, R"

In vivo imaging of cortical pathology in multiple sclerosis using ultra-high field MRI by MAINERO, C, BENNER, T, RADDING, A, VAN DER KOUWE, A, JENSEN, R, ROSEN, B. R, KINKEL, R. P

“…We used ultra-high field MRI to visualize cortical lesion types described by neuropathology in 16 patients with multiple sclerosis (MS) compared with 8…”
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Intramuscular Interferon Beta-1A Therapy Initiated during a First Demyelinating Event in Multiple Sclerosis by Jacobs, Lawrence D, Beck, Roy W, Simon, Jack H, Kinkel, R. Phillip, Brownscheidle, Carol M, Murray, Thomas J, Simonian, Nancy A, Slasor, Peter J, Sandrock, Alfred W

“…Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system that most commonly affects women, with an onset typically…”
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Multiple sclerosis susceptibility genes: associations with relapse severity and recovery by Mowry, Ellen M, Carey, Robert F, Blasco, Maria R, Pelletier, Jean, Duquette, Pierre, Villoslada, Pablo, Malikova, Irina, Roger, Elaine, Kinkel, R Phillip, McDonald, Jamie, Bacchetti, Peter, Waubant, Emmanuelle

“…Patients with early multiple sclerosis (MS) have stereotyped attack severity and recovery. We sought to determine if polymorphisms in MS susceptibility genes…”
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Focal cortical lesion detection in multiple sclerosis: 3 tesla DIR versus 7 tesla FLASH-T2 by Nielsen, A. Scott, Kinkel, R. Philip, Tinelli, Emanuele, Benner, Thomas, Cohen-Adad, Julien, Mainero, Caterina

“…Purpose: To evaluate the inter‐rater agreement of cortical lesion detection using 7 Tesla (T) FLASH‐T2* and 3T DIR sequences. Materials and Methods: Twenty‐six…”
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Asymptomatic Reactivation of JC Virus in Patients Treated with Natalizumab by Chen, Yiping, Bord, Evelyn, Tompkins, Troy, Miller, Janice, Tan, Chen S, Kinkel, R. Philip, Stein, Marion C, Viscidi, Raphael P, Ngo, Long H, Koralnik, Igor J

“…Progressive multifocal leukoencephalopathy (PML) is a rare complication of natalizumab treatment and is caused by the JC virus. In this study of 19 patients…”
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Internet portal use in an academic multiple sclerosis center by Nielsen, A Scott, Halamka, John D, Kinkel, R Philip

“…To evaluate the use of a secure internet portal in an academic Multiple Sclerosis (MS) Center. Retrospective case-control chart review of 240 patients during…”
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Quantitative Oxygen Extraction Fraction from 7-Tesla MRI Phase: Reproducibility and Application in Multiple Sclerosis by Fan, Audrey P, Govindarajan, Sindhuja T, Kinkel, R Philip, Madigan, Nancy K, Nielsen, A Scott, Benner, Thomas, Tinelli, Emanuele, Rosen, Bruce R, Adalsteinsson, Elfar, Mainero, Caterina

“…Quantitative oxygen extraction fraction (OEF) in cortical veins was studied in patients with multiple sclerosis (MS) and healthy subjects via magnetic…”
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No Evidence of Disease Activity in Multiple Sclerosis by Sloane, Jacob A, Mainero, Caterina, Kinkel, R Philip

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Axonal loss in normal-appearing white matter in a patient with acute MS by BJARTMAR, C, KINKEL, R. P, KIDD, G, RUDICK, R. A, TRAPP, B. D

“…Brain imaging studies detect abnormalities in normal-appearing white matter in patients with MS. To investigate the histopathologic basis for these changes in…”
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Efficacy of intramuscular interferon beta-1a in patients with clinically isolated syndrome: analysis of subgroups based on new risk criteria by O’Connor, P, Kinkel, RP, Kremenchutzky, M

“…Approximately 85% of multiple sclerosis (MS) cases begin as clinically isolated syndromes (CIS). Results from the Controlled High-Risk Subjects Avonex®…”
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JC virus reactivation during prolonged natalizumab monotherapy for multiple sclerosis by Chalkias, Spyridon, Dang, Xin, Bord, Evelyn, Stein, Marion C., Kinkel, R. Philip, Sloane, Jacob A., Donnelly, Maureen, Ionete, Carolina, Houtchens, Maria K., Buckle, Guy J., Batson, Stephanie, Koralnik, Igor J.

“…Objective To determine the prevalence of JC virus (JCV) reactivation and JCV‐specific cellular immune response during prolonged natalizumab treatment for…”
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Association of multiple sclerosis susceptibility variants and early attack location in the CNS by Mowry, Ellen M, Carey, Robert F, Blasco, Maria R, Pelletier, Jean, Duquette, Pierre, Villoslada, Pablo, Malikova, Irina, Roger, Elaine, Kinkel, R Phillip, McDonald, Jamie, Bacchetti, Peter, Waubant, Emmanuelle

“…The anatomic location of subsequent relapses in early multiple sclerosis (MS) appears to be predicted by the first attack location. We sought to determine if…”
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In vivo evidence of disseminated subpial T2 signal changes in multiple sclerosis at 7 T: a surface-based analysis by Cohen-Adad, J, Benner, T, Greve, D, Kinkel, R P, Radding, A, Fischl, B, Rosen, B R, Mainero, C

“…Cortical subpial demyelination is frequent in multiple sclerosis (MS) and is closely associated with disease progression and poor neurological outcome…”
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Ten-year follow-up of the ‘minimal MRI lesion’ subgroup from the original CHAMPS Multiple Sclerosis Prevention Trial by Simon, JH, Kinkel, RP, Kollman, C, O’Connor, P, Fisher, E, You, X, Hyde, R

“…Background: Patients with clinically isolated syndrome (CIS) and characteristic magnetic resonance imaging (MRI) lesions are at high risk for multiple…”
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Brain MRI lesions and atrophy are related to depression in multiple sclerosis by Bakshi, Rohit, Czarnecki, Donna, Shaikh, Zubair A, Priore, Roger L, Janardhan, Vallabh, Kaliszky, Zoltan, Kinkel, Peter R

“…It is unclear whether brain MRI lesions are associated with depression in multiple sclerosis (MS). Neurological dysfunction in depressed (n = 19) and…”
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Immune reconstitution inflammatory syndrome in patients with multiple sclerosis following cessation of natalizumab therapy by Miravalle, Augusto, Jensen, Rikke, Kinkel, R Philip

“…To assess clinical consequences of temporary natalizumab dosage suspension. Prospective cohort study. Multiple sclerosis (MS) center at an academic medical…”
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Disease-related determinants of quality of life 10 years after clinically isolated syndrome by Kinkel, R Philip, Laforet, Genevieve, You, Xiaojun

“…The main clinical determinants of quality of life (QOL) 5 years after clinically isolated syndrome (CIS) are Expanded Disability Status Scale (EDSS) score and…”
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High‐Resolution Fluorodeoxyglucose Positron Emission Tomography Shows Both Global and Regional Cerebral Hypometabolism in Multiple Sclerosis by Bakshi, Rohit, Miletich, Robert S., Kinkel, Peter R., Emmet, Marja L., Kinkel, William R.

“…The authors study brain regional glucose metabolism prospectively in multiple sclerosis (MS) using high‐resolution 2‐[18‐F]fluoro‐2‐deoxy‐D‐glucose positron…”
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Spontaneous regression of primary autoreactivity during chronic progression of experimental autoimmune encephalomyelitis and multiple sclerosis by Tuohy, V K, Yu, M, Yin, L, Kawczak, J A, Kinkel, R P

“…Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for multiple sclerosis (MS). EAE is typically initiated by CD4(+) T helper cell…”
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Maximally tolerated versus minimally effective dose: the case of rituximab in multiple sclerosis by Nielsen, A Scott, Miravalle, Augusto, Langer-Gould, Annette, Cooper, Joanna, Edwards, Keith R, Kinkel, R Philip

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