Search Results - "Kink, J A"

polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer by Dredge, K, Kink, J. A, Johnson, R. M, Bytheway, I, Marton, L. J

“…Purpose PG11047 is a polyamine analog currently in Phase I trials for advanced cancer as a monotherapy and in combination with a number of approved anti-cancer…”
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Antibodies to Recombinant Clostridium difficile Toxins A and B Are an Effective Treatment and Prevent Relapse of C. difficile-Associated Disease in a Hamster Model of Infection by KINK, J. A, WILLIAMS, J. A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Oral administration of avian tumor necrosis factor antibodies effectively treats experimental colitis in rats by WORLEDGE, Katherine L, GODISKA, Ronald, BARRETT, Terrence A, KINK, John A

“…Tumor necrosis factor (TNF) is implicated in the pathogenesis of inflammatory bowel disease. Clinical trials indicate that intravenous infusion of anti-TNF…”
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Mutations in paramecium calmodulin indicate functional differences between the C-terminal and N-terminal lobes in vivo by Kink, J A, Maley, M E, Preston, R R, Ling, K Y, Wallen-Friedman, M A, Saimi, Y, Kung, C

“…We examined calmodulin and its gene from the wild-type and viable mutants of P. tetraurelia. The mutants, selected for their behavioral aberrations, have…”
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Tunicamycin-Resistant Leishmania mexicana amazonensis: Expression of Virulence Associated with an Increased Activity of N-acetylglucosaminyltransferase and Amplification of Its Presumptive Gene by Kink, John A., Chang, Kwang-Poo

“…Tunicamycin at 10 μ g/ml inhibits the growth and infectivity of the parasitic protozoan Leishmania mexicana amazonensis. Tunicamycin-resistant variants of this…”
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DNA amplification in tunicamycin-resistant Leishmania mexicana. Multicopies of a single 63-kilobase supercoiled molecule and their expression by Detke, S, Chaudhuri, G, Kink, J A, Chang, K P

“…Tunicamycin-resistant variants of Leishmania mexicana were found to contain elevated activity of N-acetylglucosamine-1-phosphate transferase and amplified DNA…”
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Calmodulin mutants and Ca2+-dependent channels in Paramecium by PRESTON, R. R, KINK, J. A, HINRICHSEN, R. D, SAIMI, Y, CHING KUNG

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Biological and biochemical characterization of tunicamycin-resistant Leishmania mexicana: mechanism of drug resistance and virulence by KINK, J. A, KWANG-POO CHANG

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N-glycosylation as a biochemical basis for virulence in Leishmania mexicana amazonensis by Kink, J A, Chang, K P

“…Promastigotes of Leishmania mexicana amazonensis grown in vitro under different conditions showed variable degrees of virulence, as determined quantitatively…”
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Primary mutations in calmodulin prevent activation of the Ca(++)-dependent Na+ channel in Paramecium by Ling, K Y, Preston, R R, Burns, R, Kink, J A, Saimi, Y, Kung, C

“…Paramecium tetraurelia behavioral mutant cam12 displays a "fast-2" behavioral phenotype: it fails to respond to Na+ stimuli. Electrophysiologically, it lacks a…”
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Expression and size heterogeneity of a 63 kilodalton membrane glycoprotein during growth and transformation of Leishmania mexicana amazonensis by Chang, C S, Inserra, T J, Kink, J A, Fong, D, Chang, K P

“…Our previous work by immunoprecipitation with a specific monoclonal antibody showed multiple, closely apposed electrophoretic bands of a major surface antigen…”
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Efficient expression of the Paramecium calmodulin gene in Escherichia coli after four TAA-to-CAA changes through a series of polymerase chain reactions by Kink, J A, Maley, M E, Ling, K Y, Kanabrocki, J A, Kung, C

“…We have expressed the Paramecium calmodulin gene in Escherichia coli by changing the four TAA codons in this gene to CAAs. This was carried out by three…”
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A phase I clinical trial of QBI-139, a human ribonuclease variant, in solid tumors by Strong, L. E., Kink, J. A., Mei, B., Shahan, M. N., Raines, R. T.

“…Abstract only…”
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Relationship of QBI-139, a human ribonuclease variant, and RNA in cancer cells by Strong, L. E., Kink, J. A., Mei, B., Shahan, M. N., Pensinger, D., Raines, R. T.

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Use of a human ribonuclease variant, QBI-139, for the treatment of cancer by Strong, L. E., Kink, J. A., Mei, B., Shahan, M. N., Raines, R. T.

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The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer by DREDGE, K, KINK, J. A, JOHNSON, R. M, BYTHEWAY, I, MARTON, L. J

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Design of phase 1 trial of a human ribonuclease variant by Strong, L., Kink, J. A., Shahan, M. N., Mei, B., Raines, R. T.

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A Novel Polyamine Analog Inhibits Growth and Induces Apoptosis in Human Breast Cancer Cells by YI HUANG, HAGER, Erin R, CASERO, Robert A, DAVIDSON, Nancy E, PHILLIPS, Dawn L, DUNN, Valerie R, HACKER, Amy, FRYDMAN, Benjamin, KINK, John A, VALASINAS, Aldonia L, REDDY, Venodhar K, MARTON, Laurence J

“…Polyamine analogs have demonstrated considerable activity against many important solid tumor models including breast cancer. However, the precise mechanisms of…”
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Cyclopropane-Containing Polyamine Analogues Are Efficient Growth Inhibitors of a Human Prostate Tumor Xenograft in Nude Mice by Frydman, Benjamin, Blokhin, Andrei V, Brummel, Sara, Wilding, George, Maxuitenko, Yulia, Sarkar, Aparajita, Bhattacharya, Subhra, Church, Dawn, Reddy, Venodhar K, Kink, John A, Marton, Laurence J, Valasinas, Aldonia, Basu, Hirak S

“…Polyamine analogues 7, 10, 18, 27, and 32 containing cyclopropane rings were obtained by chemical synthesis. Their antineoplastic activities were assessed…”
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Calmodulin mutants and Ca super(2+)-dependent channels in Paramecium by Preston, R R, Kink, JA, Hinrichsen, R D, Saimi, Y, Kung, Ching

“…This review describes how combined genetic, electrophysiological, biochemical, and molecular studies have enhanced our understanding of how Ca…”
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