Ayurvedic Drug Triphala in Combination with Providone Iodine Mitigates Radiation-Induced Mucositis in Head and Neck Cancer Patients without Affecting the Tumor Response

Ayurvedic Drug Triphala in Combination with Providone Iodine Mitigates Radiation-Induced Mucositis in Head and Neck Cancer Patients without Affecting the Tumor Response

Radiation-induced mucositis is a dose-limiting concern in the treatment of head and neck cancers (HNC). This study was conducted to determine the effectiveness of the Ayurvedic drug Triphala in reducing radiation-induced mucositis and influencing tumour control when combined with providone iodine. D...

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Bibliographic Details
Published in:Indian journal of otolaryngology, and head, and neck surgery Vol. 75; no. 3; pp. 1480 - 1489
Main Authors: Rao, Suresh, Kini, Venkataraman, Hegde, Sanath Kumar, Meera, Sharake, Rao, Pratima, George, Thomas, Baliga, Manjeshwar Shrinath
Format: Journal Article
Language:English
Published: New Delhi Springer India 01-09-2023
Springer Nature B.V
Subjects:
Head & neck cancer
Head and Neck Surgery
Iodine
Medicine
Medicine & Public Health
Mucositis
Original
Original Article
Otorhinolaryngology
Radiation
Head and neck cancer
Treatment response
Triphala
Mucositis
Cell kill
Radiation
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Summary:Radiation-induced mucositis is a dose-limiting concern in the treatment of head and neck cancers (HNC). This study was conducted to determine the effectiveness of the Ayurvedic drug Triphala in reducing radiation-induced mucositis and influencing tumour control when combined with providone iodine. Data from patient files of HNC patients who received Triphala in conjunction with iodine or iodine alone over the course of curative radiotherapy (> 60 Gy) from May 2013 to February 2015 were extracted for this retrospective chart based study. Data was subjected to statistical analysis, X2 and unpaired t test using the Statistical Package for Social Sciences (SPSS), version 17 (IBM, Chicago, USA). When compared to iodine alone, the group that utilised Triphala gargling was very efficient in delaying mucositis, the extent of weight loss ( p  = 0.038), the incidence ( p  = 0.03), and the number ( p  = 0.02) of treatment breaks. However, it had no influence on the radiation-induced tumour response. According to the observations, Triphala coupled with iodine was more successful in preventing radiation mucositis, and without affecting the killing of tumour cells than iodine gargle alone. According to the authors, this is the first observation to demonstrate the value of combining providone iodine with Triphala in preventing radiation-induced oral mucositis.
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ISSN:2231-3796
0973-7707
DOI:10.1007/s12070-023-03516-8