Search Results - "Kingston, David G.I."

Antiproliferative homoscalarane sesterterpenes from two Madagascan sponges by Harinantenaina, Liva, Brodie, Peggy J., Maharavo, Jean, Bakary, Gisele, TenDyke, Karen, Shen, Yongchun, Kingston, David G.I.

“…Dereplication of the antiproliferative ethyl acetate fraction of the Madagascan sponge Carteriospongia sp. led to the detection and isolation of the two known…”
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Isolation and synthesis of two antiproliferative calamenene-type sesquiterpenoids from Sterculia tavia from the Madagascar Rain Forest by Dai, Yumin, Harinantenaina, Liva, Brodie, Peggy J., Callmander, Martin W., Randrianasolo, Sennen, Rakotobe, Etienne, Rasamison, Vincent E., Kingston, David G.I.

“…Investigation of the endemic Madagascan plant Sterculia taiva Baill. (Malvaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led…”
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Bioactive compounds from Stuhlmannia moavi from the Madagascar dry forest by Liu, Yixi, Harinantenaina, Liva, Brodie, Peggy J., Bowman, Jessica D., Cassera, Maria B., Slebodnick, Carla, Callmander, Martin W., Randrianaivo, Richard, Rakotobe, Etienne, Rasamison, Vincent E., Applequist, Wendy, Birkinshaw, Chris, Lewis, Gwilym P., Kingston, David G.I.

“…Bioassay-directed fractionation of the leaf and root extracts of the antiproliferative Madagascar plant Stuhlmannia moavi afforded…”
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Saponins and a lignan derivative of Terminalia tropophylla from the Madagascar Dry Forest by Cao, Shugeng, Brodie, Peggy J., Callmander, Martin, Randrianaivo, Richard, Rakotobe, Etienne, Rasamison, Vincent E., Kingston, David G.I.

“…A study of an EtOH extract obtained from the roots of the Madagascan plant Terminalia tropophylla H. Perrier (Combretaceae) led to the isolation of the new…”
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Tubulin-Interactive Natural Products as Anticancer Agents by Kingston, David G. I

“…This review provides an overview of the discovery, structures, and biological activities of anticancer natural products that act by inhibiting or promoting the…”
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Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin by Qi, Jun, Blanden, Adam R., Bane, Susan, Kingston, David G.I.

“…The design, synthesis, and biological evaluation of a simplified fluorescently labeled discodermolide analogue possessing a dimethylaminobenzoyl fluorophore…”
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Colloidal gold nanoparticles: a novel nanoparticle platform for developing multifunctional tumor-targeted drug delivery vectors by Paciotti, Giulio F., Kingston, David G.I., Tamarkin, Lawrence

“…Nanotechnology applied to biological problems represents an emerging field with the potential to offer extremely sensitive diagnostics and targeted cancer…”
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The shape of things to come: Structural and synthetic studies of taxol and related compounds by Kingston, David G.I.

“…The history of the development of Taxol ® (paclitaxel) as an anticancer drug is reviewed, aspects of the phytochemistry of Taxus species, of the medicinal…”
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Flavanones from the Twigs and Barks of Artocarpus lakoocha Having Antiplasmodial and Anti-TB Activities by Boonyaketgoson, Sirada, Du, Yongle, Murillo, Ana L. Valenciano, Cassera, Maria B., Kingston, David G. I., Trisuwan, Kongkiat

“…Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone…”
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Structure and stereochemistry of a novel bioactive sphingolipid from a Calyx sp by Zhou, Bing-Nan, Mattern, Michael P, Johnson, Randall K, Kingston, David G.I

“…Bioassay-directed fractionation of a sponge of the genus Calyx using a yeast bioassay for DNA-damaging agents yielded the novel sphingolipid calyxoside ( 1) as…”
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Antiproliferative compounds from Ocotea macrocarpa from the Madagascar dry forest by Liu, Yixi, Cheng, Emily, Harinantenaina Rakotondraibe, L., Brodie, Peggy J., Applequist, Wendy, Randrianaivo, Richard, Rakotondrafara, Andriamalala, Ratsimbason, Michel, Rasamison, Vincent E., Kingston, David G.I.

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A Bioactive Spirolactone Iridoid and Triterpenoids from Himatanthus sucuuba by WOOD, Christina A., LEE, Kit, VAISBERG, Abraham J., KINGSTON, David G.I., NETO, Catherine C., HAMMOND, Gerald B.

“…Himatanthus sucuuba is an Amazonian tree with abundant, yet conflicting ethnobotanical information. Investigation of the polar and non-polar constituents led…”
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Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation by Zhao, Jielu, Bane, Susan, Snyder, James P., Hu, Haipeng, Mukherjee, Kamalika, Slebodnick, Carla, Kingston, David G.I.

“…A series of compounds designed to adopt a conformation similar to the tubulin-binding T-Taxol conformation of the anticancer drug paclitaxel has been…”
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Cardenolides of Leptadenia madagascariensis from the Madagascar dry forest by Pan, Ende, Harinantenaina, Liva, Brodie, Peggy J., Callmander, Martin, Rakotonandrasana, Stephan, Rakotobe, Etienne, Rasamison, Vincent E., TenDyke, Karen, Shen, Yongchun, Suh, Edward M., Kingston, David G.I.

“…Investigation of the endemic Madagascar plant Leptadenia madagascariensis Decne. (Apocynaceae) for antiproliferative activity against the A2780 ovarian cancer…”
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Euphane triterpenoids of Cassipourea lanceolata from the Madagascar rainforest by Hou, Yanpeng, Cao, Shugeng, Brodie, Peggy J., Miller, James S., Birkinshaw, Chris, Andrianjafy, Mamisoa N., Andriantsiferana, Rabodo, Rasamison, Vincent E., TenDyke, Karen, Shen, Yongchun, Suh, Edward M., Kingston, David G.I.

“…A Madagascar collection of the leaves and fruit of Cassipourea lanceolata Tul. led to the isolation of three euphane triterpenoids 1– 3. The three compounds…”
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Ovarian antiproliferative activity directed isolation of triterpenoids from fruits of Eucalyptus camaldulensis Dehnh by Topçu, Gülaçtı, Yapar, Gönül, Türkmen, Zeynep, Gören, Ahmet Ceyhan, Öksüz, Sevil, Schilling, Jennifer K., Kingston, David G.I.

“…Bioassay-guided fractionation of the direct methanol extract of the fruits of Eucalyptus camaldulensis Dehnh. afforded a new triterpenoid,…”
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Antiproliferative Bistramides from Trididemnum cyclops from Madagascar by Murphy, Brian T, Cao, Shugeng, Brodie, Peggy, Maharavo, Jean, Andriamanantoanina, Hanta, Ravelonandro, Pierre, Kingston, David G. I

“…Bioassay-guided fractionation of a marine extract from Trididemnum cyclops afforded the new lipopeptide 39-oxobistramide K (1) and the known bistramides A (2)…”
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A fluorescence-based high-throughput assay for antimicrotubule drugs by Barron, Donna M, Chatterjee, Sabarni K, Ravindra, Rudravajhala, Roof, Rebecca, Baloglu, Erkan, Kingston, David G.I, Bane, Susan

“…With the advent of combinatorial chemistry and the extensive libraries of potential drugs produced from it, there is a growing need for rapid sensitive,…”
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A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest by Williams, Russell B, Hoch, Jeannine, Glass, Thomas E, Evans, Randy, Miller, James S, Wisse, Jan H, Kingston, David G

“…Bioassay-guided fractionation of the EtOAc extract of the twigs of Garcinia macrophylla from Suriname produced the known benzophenone, guttiferone A (1), and a…”
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Taxol: the chemistry and structure-activity relationships of a novel anticancer agent by Kingston, D G

“…Taxol is an exciting new anticancer drug, showing clinical activity against ovarian and breast cancer. Its development as a clinically useful drug has involved…”
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