Search Results - "Kingston, Benjamin R."

Three-Dimensional Imaging of Transparent Tissues via Metal Nanoparticle Labeling by Syed, Abdullah Muhammad, Sindhwani, Shrey, Wilhelm, Stefan, Kingston, Benjamin R, Lee, Dennis S. W, Gommerman, Jennifer L, Chan, Warren C. W

“…Chemical probes are key components of the bioimaging toolbox, as they label biomolecules in cells and tissues. The new challenge in bioimaging is to design…”
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Toward Predicting Nanoparticle Distribution in Heterogeneous Tumor Tissues by MacMillan, Presley, Syed, Abdullah M., Kingston, Benjamin R., Ngai, Jessica, Sindhwani, Shrey, Lin, Zachary P., Nguyen, Luan N. M., Ngo, Wayne, Mladjenovic, Stefan M., Ji, Qin, Blackadar, Colin, Chan, Warren C. W.

“…Nanobio interaction studies have generated a significant amount of data. An important next step is to organize the data and design computational techniques to…”
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A framework for designing delivery systems by Poon, Wilson, Kingston, Benjamin R., Ouyang, Ben, Ngo, Wayne, Chan, Warren C. W.

“…The delivery of medical agents to a specific diseased tissue or cell is critical for diagnosing and treating patients. Nanomaterials are promising vehicles to…”
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Applying artificial intelligence and computational modeling to nanomedicine by Hamilton, Sean, Kingston, Benjamin R

“…Achieving specific and targeted delivery of nanomedicines to diseased tissues is a major challenge. This is because the process of designing, formulating,…”
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Elimination Pathways of Nanoparticles by Poon, Wilson, Zhang, Yi-Nan, Ouyang, Ben, Kingston, Benjamin R, Wu, Jamie L. Y, Wilhelm, Stefan, Chan, Warren C. W

“…Understanding how nanoparticles are eliminated from the body is required for their successful clinical translation. Many promising nanoparticle formulations…”
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The entry of nanoparticles into solid tumours by Sindhwani, Shrey, Syed, Abdullah Muhammad, Ngai, Jessica, Kingston, Benjamin R., Maiorino, Laura, Rothschild, Jeremy, MacMillan, Presley, Zhang, Yuwei, Rajesh, Netra Unni, Hoang, Tran, Wu, Jamie L. Y., Wilhelm, Stefan, Zilman, Anton, Gadde, Suresh, Sulaiman, Andrew, Ouyang, Ben, Lin, Zachary, Wang, Lisheng, Egeblad, Mikala, Chan, Warren C. W.

“…The concept of nanoparticle transport through gaps between endothelial cells (inter-endothelial gaps) in the tumour blood vessel is a central paradigm in…”
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The dose threshold for nanoparticle tumour delivery by Ouyang, Ben, Poon, Wilson, Zhang, Yi-Nan, Lin, Zachary P., Kingston, Benjamin R., Tavares, Anthony J., Zhang, Yuwei, Chen, Juan, Valic, Michael S., Syed, Abdullah M., MacMillan, Presley, Couture-Senécal, Julien, Zheng, Gang, Chan, Warren C. W.

“…Nanoparticle delivery to solid tumours over the past ten years has stagnated at a median of 0.7% of the injected dose. Varying nanoparticle designs and…”
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Specific Endothelial Cells Govern Nanoparticle Entry into Solid Tumors by Kingston, Benjamin R, Lin, Zachary P, Ouyang, Ben, MacMillan, Presley, Ngai, Jessica, Syed, Abdullah Muhammad, Sindhwani, Shrey, Chan, Warren C. W

“…The successful delivery of nanoparticles to solid tumors depends on their ability to pass through blood vessels and into the tumor microenvironment. Here, we…”
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Assessing micrometastases as a target for nanoparticles using 3D microscopy and machine learning by Kingston, Benjamin R., Syed, Abdullah Muhammad, Ngai, Jessica, Sindhwani, Shrey, Chan, Warren C. W.

“…Metastasis of solid tumors is a key determinant of cancer patient survival. Targeting micrometastases using nanoparticles could offer a way to stop metastatic…”
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Nanoparticle Size Influences Antigen Retention and Presentation in Lymph Node Follicles for Humoral Immunity by Zhang, Yi-Nan, Lazarovits, James, Poon, Wilson, Ouyang, Ben, Nguyen, Luan N. M, Kingston, Benjamin R, Chan, Warren C. W

“…Lymph node follicles capture and retain antigens to induce germinal centers and long-lived humoral immunity. However, control over antigen retention has been…”
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Endothelialized collagen based pseudo-islets enables tuneable subcutaneous diabetes therapy by Vlahos, Alexander E., Kinney, Sean M., Kingston, Benjamin R., Keshavjee, Sara, Won, So-Yoon, Martyts, Anastasiya, Chan, Warren C.W., Sefton, Michael V.

“…Pancreatic islets are fragile cell clusters and many isolated islets are not suitable for transplantation. Furthermore, following transplantation, islets will…”
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Delineating the tumour microenvironment response to a lipid nanoparticle formulation by Ngai, Jessica, MacMillan, Presley, Kingston, Benjamin R., Lin, Zachary P., Ouyang, Ben, Chan, Warren C.W.

“…Nanoparticles can reduce cytotoxicity, increase circulation time and increase accumulation in tumours compared to free drug. However, the value of using…”
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Liposome Imaging in Optically Cleared Tissues by Syed, Abdullah Muhammad, MacMillan, Presley, Ngai, Jessica, Wilhelm, Stefan, Sindhwani, Shrey, Kingston, Benjamin R, Wu, Jamie L. Y, Llano-Suárez, Pablo, Lin, Zachary Pengju, Ouyang, Ben, Kahiel, Zaina, Gadde, Suresh, Chan, Warren C. W

“…Three-dimensional (3D) optical microscopy can be used to understand and improve the delivery of nanomedicine. However, this approach cannot be performed for…”
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Macrophages Actively Transport Nanoparticles in Tumors After Extravasation by Lin, Zachary Pengju, Nguyen, Luan N. M, Ouyang, Ben, MacMillan, Presley, Ngai, Jessica, Kingston, Benjamin R, Mladjenovic, Stefan M, Chan, Warren C. W

“…Nanoparticles need to navigate a complex microenvironment to target cells in solid tumors after extravasation. Diffusion is currently the accepted primary…”
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Impact of Tumor Barriers on Nanoparticle Delivery to Macrophages by Ouyang, Ben, Kingston, Benjamin R., Poon, Wilson, Zhang, Yi-Nan, Lin, Zachary P., Syed, Abdullah M., Couture-Senécal, Julien, Chan, Warren C. W.

“…The delivery of therapeutic nanoparticles to target cells is critical to their effectiveness. Here we quantified the impact of biological barriers on the…”
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Transcribing In Vivo Blood Vessel Networks into In Vitro Perfusable Microfluidic Devices by Chen, Yih Yang, Kingston, Benjamin R., Chan, Warren C. W.

“…The 3D architecture of blood vessel networks dictates how nutrients, waste, and drugs are transported. These transport processes are difficult to study in…”
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Cancer Cartography: Three-Dimensional Mapping of Tumours to Understand and Improve Nanoparticle Delivery by Kingston, Benjamin R

“…Nanoparticles offer a flexible platform for delivering therapeutic and diagnostic agents to solid tumours. Researchers have developed the ability to control…”
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