Search Results - "Kingston, Ann E"

CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography by Wright, Rebecca A., Johnson, Bryan G., Zhang, Ce, Salhoff, Craig, Kingston, Ann E., Calligaro, David O., Monn, James A., Schoepp, Darryle D., Marek, Gerard J.

“…Group II metabotropic glutamate (mGlu) receptor agonists were efficacious in randomized clinical research trials for schizophrenia and generalized anxiety…”
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Astrocyte function is modified by Alzheimer's disease-like pathology in aged mice by Peters, Oliver, Schipke, Carola G, Philipps, Andreas, Haas, Brigitte, Pannasch, Ulrike, Wang, Li Ping, Benedetti, Bruno, Kingston, Ann E, Kettenmann, Helmut

“…Alzheimer's disease (AD) may affect all cell types in the central nervous system. Astrocytes have rarely been investigated in the aged brain and the role of…”
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Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039) by Rorick-Kehn, Linda M, Johnson, Bryan G, Burkey, Jennifer L, Wright, Rebecca A, Calligaro, David O, Marek, Gerard J, Nisenbaum, Eric S, Catlow, John T, Kingston, Ann E, Giera, Deborah D, Herin, Marc F, Monn, James A, McKinzie, David L, Schoepp, Darryle D

“…Group II metabotropic glutamate (mGlu) receptor agonists, including (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate monohydrate (LY354740) and…”
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Prospects for Metabotropic Glutamate 1 Receptor Antagonists in the Treatment of Neuropathic Pain by Schkeryantz, Jeffrey M, Kingston, Ann E, Johnson, Michael P

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Anticonvulsant effects of LY456236, a selective mGlu1 receptor antagonist by Shannon, Harlan E., Peters, Steven C., Kingston, Ann E.

“…Several lines of evidence suggest that mGlu1 metabotropic glutamate receptors may be involved in seizure disorders such as epilepsy. For example, the mGlu1…”
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Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus by Gillard, Samantha E., Tzaferis, John, Tsui, Ho-Ching Tiffany, Kingston, Ann E.

“…This study investigated the distribution of metabotropic glutamate receptors (mGluRs) in meningeal and parenchymal microvasculature and in choroid plexus by…”
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Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide by Casley, Christopher S, Lakics, Viktor, Lee, Hyoung-gon, Broad, Lisa M, Day, Theresa A, Cluett, Tricia, Smith, Mark A, O'Neill, Michael J, Kingston, Ann E

“…Abstract The effects of amyloid-beta peptide (Aβ) on astrocyte responses to activation of mGlu5 receptors have been investigated using calcium imaging…”
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Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand by Jong, Yuh-Jiin I, Kumar, Vikas, Kingston, Ann E, Romano, Carmelo, O'Malley, Karen L

“…G-protein-coupled receptors are well known for converting an extracellular signal into an intracellular response. Here we showed that the metabotropic…”
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Defective Tumor Necrosis Factor-α-dependent Control of Astrocyte Glutamate Release in a Transgenic Mouse Model of Alzheimer Disease by Rossi, Daniela, Brambilla, Liliana, Valori, Chiara F., Crugnola, Andrea, Giaccone, Giorgio, Capobianco, Raffaella, Mangieri, Michela, Kingston, Ann E., Bloc, Alain, Bezzi, Paola, Volterra, Andrea

“…The cytokine tumor necrosis factor-α (TNFα) induces Ca2+-dependent glutamate release from astrocytes via the downstream action of prostaglandin (PG) E2. By…”
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( S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord by Thomas, Nicola K, Wright, Rebecca A, Howson, Patrick A, Kingston, Ann E, Schoepp, Darryle D, Jane, David E

“…( S)-3,4-Dicarboxyphenylglycine (DCPG) has been tested on cloned human mGlu1–8 receptors individually expressed in AV12-664 cells co-expressing a rat…”
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DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists by Fitzjohn, Stephen M, Kingston, Ann E, Lodge, David, Collingridge, Graham L

“…We have used extracellular microelectrode recording to characterise a form of long-term depression (LTD) of synaptic transmission that can be induced by…”
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Metabotropic Glutamate 2 Receptors Modulate Synaptic Inputs and Calcium Signals in Striatal Cholinergic Interneurons by Pisani, Antonio, Bonsi, Paola, Catania, Maria Vincenza, Giuffrida, Raffaella, Morari, Michele, Marti, Matteo, Centonze, Diego, Bernardi, Giorgio, Kingston, Ann E, Calabresi, Paolo

“…Striatal cholinergic interneurons were recorded from a rat slice preparation. Synaptic potentials evoked by intrastriatal stimulation revealed three distinct…”
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Neuroprotection by metabotropic glutamate receptor agonists: LY354740, LY379268 and LY389795 by Kingston, Ann E, O'Neill, Michael J, Lam, Amy, Bales, Kelly R, Monn, James A, Schoepp, Darryle D

“…In rat cortical neuronal cultures, metabotropic glutamate (mGlu) receptor agonists: LY354740 (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate); LY379268…”
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(2S,1‘S,2‘R,3‘R)-2-(2‘-Carboxy-3‘-hydroxymethylcyclopropyl) Glycine Is a Highly Potent Group 2 and 3 Metabotropic Glutamate Receptor Agonist with Oral Activity by Collado, Iván, Pedregal, Concepción, Bueno, Ana Belén, Marcos, Alicia, González, Rosario, Blanco-Urgoiti, Jaime, Pérez-Castells, Javier, Schoepp, Darryle D, Wright, Rebecca A, Johnson, Bryan G, Kingston, Ann E, Moher, Eric D, Hoard, David W, Griffey, Kelly I, Tizzano, Joseph P

“…The asymmetric synthesis and biological activity of (2S,1‘S,2‘R,3‘R)-2-(2‘-carboxy-3‘-hydroxymethylcyclopropyl) glycine ((+)-3) is described. This novel C-3‘…”
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Functional Metabotropic Glutamate Receptors on Nuclei from Brain and Primary Cultured Striatal Neurons by Jong, Yuh-Jiin I., Kumar, Vikas, Kingston, Ann E., Romano, Carmelo, O'Malley, Karen L.

“…G-protein-coupled receptors are well known for converting an extracellular signal into an intracellular response. Here we showed that the metabotropic…”
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(2S,1‘S,2‘S,3‘R)-2-(2‘-Carboxy-3‘-methylcyclopropyl) Glycine Is a Potent and Selective Metabotropic Group 2 Receptor Agonist with Anxiolytic Properties by Collado, Iván, Pedregal, Concepción, Mazón, Angel, Espinosa, Juan Félix, Blanco-Urgoiti, Jaime, Schoepp, Darryle D, Wright, Rebecca A, Johnson, Bryan G, Kingston, Ann E

“…The asymmetric synthesis and biological activity of (2S,1‘S,2‘S,3‘R)-2-(2‘-carboxy-3‘-methylcyclopropyl) glycine 7 and its epimer at the C3‘ center 6 are…”
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Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists by Kingston, Ann E, Griffey, Kelly, Johnson, Michael P, Chamberlain, Mary-Jo, Kelly, Gerald, Tomlinson, Rosemarie, Wright, Rebecca A, Johnson, Bryan G, Schoepp, Darryle D, Harris, John R, Clark, Barry P, Baker, Richard S, Tizzano, Joseph P

“…A series of novel group I metabotropic glutamate receptor (mGlu) antagonists have been designed on the basis of the 4-carboxyphenylglycine pharmacophore. The…”
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HOUT-15. BRAIN TUMOR PATIENT AND CAREGIVER SURVEY ON CLINICAL TRIALS: IDENTIFYING ATTITUDES AND BARRIERS TO PATIENT PARTICIPATION by Bates, Amanda J, Couillard, Samantha A, Arons, David F, Yung, W K Alfred, Vogelbaum, Michael, Wen, Patrick Y, Kingston, Ann E

“…The National Brain Tumor Society conducted an online survey to determine if, when, and how information about clinical trials is provided to brain tumor…”
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Prospects for metabotropic glutamate 1 receptor antagonists in the treatment of neuropathic pain : Recent approaches in the treatment of neuropathic pain by SCHKERYANTZ, Jeffrey M, KINGSTON, Ann E, JOHNSON, Michael P

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(+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors by Clark, Barry P., Baker, S.Richard, Goldsworthy, John, Harris, John R., Kingston, Ann E.

“…The synthesis of three novel 4-carboxyphenylglycine derivatives is described. 2-Methyl substituents increase the antagonist potency compared to (S)-4CPG at…”
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