Search Results - "Kingsley, Paul D"

A human cell atlas of fetal gene expression by Cao, Junyue, O'Day, Diana R, Pliner, Hannah A, Kingsley, Paul D, Deng, Mei, Daza, Riza M, Zager, Michael A, Aldinger, Kimberly A, Blecher-Gonen, Ronnie, Zhang, Fan, Spielmann, Malte, Palis, James, Doherty, Dan, Steemers, Frank J, Glass, Ian A, Trapnell, Cole, Shendure, Jay

“…The gene expression program underlying the specification of human cell types is of fundamental interest. We generated human cell atlases of gene expression and…”
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Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo by McGrath, Kathleen E., Frame, Jenna M., Fegan, Katherine H., Bowen, James R., Conway, Simon J., Catherman, Seana C., Kingsley, Paul D., Koniski, Anne D., Palis, James

“…Hematopoietic potential arises in mammalian embryos before adult-repopulating hematopoietic stem cells (HSCs). At embryonic day 9.5 (E9.5), we show the first…”
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Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development by Dege, Carissa, Fegan, Katherine H., Creamer, J. Philip, Berrien-Elliott, Melissa M., Luff, Stephanie A., Kim, Darren, Wagner, Julia A., Kingsley, Paul D., McGrath, Kathleen E., Fehniger, Todd A., Palis, James, Sturgeon, Christopher M.

“…Natural killer (NK) cells are a critical component of the innate immune system. However, their ontogenic origin has remained unclear. Here, we report that NK…”
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Ontogeny of erythroid gene expression by Kingsley, Paul D., Greenfest-Allen, Emily, Frame, Jenna M., Bushnell, Timothy P., Malik, Jeffrey, McGrath, Kathleen E., Stoeckert, Christian J., Palis, James

“…Erythroid ontogeny is characterized by overlapping waves of primitive and definitive erythroid lineages that share many morphologic features during terminal…”
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Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function by Fox, Sierra, Myers, Jacquelyn A., Davidson, Christina, Getman, Michael, Kingsley, Paul D., Frankiewicz, Nicholas, Bulger, Michael

“…Stratification of enhancers by signal strength in ChIP-seq assays has resulted in the establishment of super-enhancers as a widespread and useful tool for…”
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Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis by Keel, Siobán B, Doty, Raymond T, Yang, Zhantao, Quigley, John G, Chen, Jing, Knoblaugh, Sue, Kingsley, Paul D, De Domenico, Ivana, Vaughn, Michael B, Kaplan, Jerry, Palis, James, Abkowitz, Janis L

“…Hemoproteins are critical for the function and integrity of aerobic cells. However, free heme is toxic. Therefore, cells must balance heme synthesis with its…”
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Discovery of Genes Essential for Heme Biosynthesis through Large-Scale Gene Expression Analysis by Nilsson, Roland, Schultz, Iman J., Pierce, Eric L., Soltis, Kathleen A., Naranuntarat, Amornrat, Ward, Diane M., Baughman, Joshua M., Paradkar, Prasad N., Kingsley, Paul D., Culotta, Valeria C., Kaplan, Jerry, Palis, James, Paw, Barry H., Mootha, Vamsi K.

“…Heme biosynthesis consists of a series of eight enzymatic reactions that originate in mitochondria and continue in the cytosol before returning to…”
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FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity by Yien, Yvette Y., Shi, Jiahai, Chen, Caiyong, Cheung, Jesmine T.M., Grillo, Anthony S., Shrestha, Rishna, Li, Liangtao, Zhang, Xuedi, Kafina, Martin D., Kingsley, Paul D., King, Matthew J., Ablain, Julien, Li, Hojun, Zon, Leonard I., Palis, James, Burke, Martin D., Bauer, Daniel E., Orkin, Stuart H., Koehler, Carla M., Phillips, John D., Kaplan, Jerry, Ward, Diane M., Lodish, Harvey F., Paw, Barry H.

“…Erythropoietin (EPO) signaling is critical to many processes essential to terminal erythropoiesis. Despite the centrality of iron metabolism to erythropoiesis,…”
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EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress by Peslak, Scott A., Wenger, Jesse, Bemis, Jeffrey C., Kingsley, Paul D., Koniski, Anne D., McGrath, Kathleen E., Palis, James

“…Erythropoiesis is a robust process of cellular expansion and maturation occurring in murine bone marrow and spleen. We previously determined that sublethal…”
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Histone H2A.X phosphorylation and Caspase-Initiated Chromatin Condensation in late-stage erythropoiesis by Jeffery, Nazish N, Davidson, Christina, Peslak, Scott A, Kingsley, Paul D, Nakamura, Yukio, Palis, James, Bulger, Michael

“…Condensation of chromatin prior to enucleation is an essential component of terminal erythroid maturation, and defects in this process are associated with…”
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Yolk sac–derived primitive erythroblasts enucleate during mammalian embryogenesis by Kingsley, Paul D., Malik, Jeffrey, Fantauzzo, Katherine A., Palis, James

“…The enucleated definitive erythrocytes of mammals are unique in the animal kingdom. The observation that yolk sac–derived primitive erythroid cells in mammals…”
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Enucleation of primitive erythroid cells generates a transient population of “pyrenocytes” in the mammalian fetus by McGrath, Kathleen E., Kingsley, Paul D., Koniski, Anne D., Porter, Rebecca L., Bushnell, Timothy P., Palis, James

“…Enucleation is the hallmark of erythropoiesis in mammals. Previously, we determined that yolk sac–derived primitive erythroblasts mature in the bloodstream and…”
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Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating by Huang, Yu-Shan, Delgadillo, Luis F., Cyr, Kathryn H., Kingsley, Paul D., An, Xiuli, McGrath, Kathleen E., Mohandas, Narla, Conboy, John G., Waugh, Richard E., Wan, Jiandi, Palis, James

“…Hematopoietic ontogeny is characterized by distinct primitive and definitive erythroid lineages. Definitive erythroblasts mature and enucleate extravascularly…”
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Ascl3 expression marks a progenitor population of both acinar and ductal cells in mouse salivary glands by Bullard, Tara, Koek, Laurie, Roztocil, Elisa, Kingsley, Paul D., Mirels, Lily, Ovitt, Catherine E.

“…Ascl3, also know as Sgn1, is a member of the mammalian achaete scute ( Mash) gene family of transcription factors, which have been implicated in cell fate…”
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“Maturational” globin switching in primary primitive erythroid cells by Kingsley, Paul D., Malik, Jeffrey, Emerson, Rachel L., Bushnell, Timothy P., McGrath, Kathleen E., Bloedorn, Laura A., Bulger, Michael, Palis, James

“…Mammals have 2 distinct erythroid lineages. The primitive erythroid lineage originates in the yolk sac and generates a cohort of large erythroblasts that…”
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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter by Zon, Leonard I, Donovan, Adriana, Brownlie, Alison, Zhou, Yi, Shepard, Jennifer, Pratt, Stephen J, Moynihan, John, Paw, Barry H, Drejer, Anna, Barut, Bruce, Zapata, Agustin, Law, Terence C, Brugnara, Carlo, Lux, Samuel E, Pinkus, Geraldine S, Pinkus, Jack L, Kingsley, Paul D, Palis, James, Fleming, Mark D, Andrews, Nancy C

“…Defects in iron absorption and utilization lead to iron deficiency and overload disorders. Adult mammals absorb iron through the duodenum, whereas embryos…”
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Sox6 directly silences epsilon globin expression in definitive erythropoiesis by Yi, Zanhua, Cohen-Barak, Orit, Hagiwara, Nobuko, Kingsley, Paul D, Fuchs, Deborah A, Erickson, Drew T, Epner, Elliot M, Palis, James, Brilliant, Murray H

“…Sox6 is a member of the Sox transcription factor family that is defined by the conserved high mobility group (HMG) DNA binding domain, first described in the…”
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Lineage analysis of the hemangioblast as defined by FLK1 and SCL expression by Chung, Yun Shin, Zhang, Wen Jie, Arentson, Elizabeth, Kingsley, Paul D, Palis, James, Choi, Kyunghee

“…Accumulating studies support the idea that a common progenitor, termed the hemangioblast, generates both hematopoietic and endothelial cell lineages. To better…”
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Sublethal radiation injury uncovers a functional transition during erythroid maturation by Peslak, Scott A, Wenger, Jesse, Bemis, Jeffrey C, Kingsley, Paul D, Frame, Jenna M, Koniski, Anne D, Chen, Yuhchyau, Williams, Jacqueline P, McGrath, Kathleen E, Dertinger, Stephen D, Palis, James

“…Objective Clastogenic injury of the erythroid lineage results in anemia, reticulocytopenia, and transient appearance of micronucleated reticulocytes. However,…”
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Bmi-1 Regulates Extensive Erythroid Self-Renewal by Kim, Ah Ram, Olsen, Jayme L., England, Samantha J., Huang, Yu-Shan, Fegan, Katherine H., Delgadillo, Luis F., McGrath, Kathleen E., Kingsley, Paul D., Waugh, Richard E., Palis, James

“…Red blood cells (RBCs), responsible for oxygen delivery and carbon dioxide exchange, are essential for our well-being. Alternative RBC sources are needed to…”
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