Anthrax vaccine adsorbed: Further evidence supporting continuing the vaccination series rather than restarting the series when doses are delayed

Highlights • The anti-PA IgG antibody response and B. anthracis lethal toxin neutralization activity of a cohort delayed as long as 7 years in receiving an anthrax vaccine dose was robust and non-inferior to the responses of the on-schedule cohort. • Non-inferiority of anti-PA IgG antibody levels an...

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Bibliographic Details
Published in:	Vaccine Vol. 32; no. 39; pp. 5131 - 5139
Main Authors:	Pittman, Phillip R, Cavicchia, M.A, Kingsbury, J.L, Johnson, N.A, Barrera-Oro, J.G, Schmader, T, Korman, L, Quinn, X, Ranadive, M
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 03-09-2014 Elsevier Elsevier Limited
Subjects:	Adolescent Adult Allergy and Immunology Anthrax Anthrax - prevention & control Anthrax vaccine adsorbed Anthrax Vaccines - administration & dosage Antibodies, Bacterial - blood Antibodies, Neutralizing - blood Antibody Formation Antigens, Bacterial - immunology Applied microbiology Armed forces Bacillus anthracis Bacterial Toxins - immunology Bacteriology Biological and medical sciences Biothrax Cytotoxicity Drug dosages Ethnicity Female Fundamental and applied biological sciences. Psychology Gender Hispanic Americans Human antibody response to Biothrax Humans Immunization Schedule Immunoglobulin G - blood Male Microbiology Middle Aged Military personnel Miscellaneous Neutralization Neutralization Tests Prospective Studies Protection against Bacillus anthracis Time Factors Toxins Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Young Adult United States > US Anthrax vaccine adsorbed Human antibody response to Biothrax Biothrax Protection against Bacillus anthracis Human Bacillus anthracis Immune response Vaccination Vaccine Bacillaceae Infection Bacillales Anthrax Bacteriosis Bacteria Humoral immunity Human antibody response to Biothrax(®) Biothrax(®)
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Summary:	Highlights • The anti-PA IgG antibody response and B. anthracis lethal toxin neutralization activity of a cohort delayed as long as 7 years in receiving an anthrax vaccine dose was robust and non-inferior to the responses of the on-schedule cohort. • Non-inferiority of anti-PA IgG antibody levels and B. anthracis lethal toxin neutralization activity persisted until the next dose. • Racial categories “African American or Black” and “Asian or Pacific Islander” had lower anti-PA IgG antibody levels than “Whites”. The clinical relevance of this finding is unknown. • Although there were differences in anti-PA IgG antibody response and B. anthracis lethal toxin neutralization activity by age and gender, these differences were not statistically significant in this study.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2014.03.076