Search Results - "Kinghorn, A. D."

Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells by Choi, Juliana K., Murillo, Genoveva, Su, Bao‐Ning, Pezzuto, John M., Kinghorn, A. D., Mehta, Rajendra G.

“…Physalis philadelphica Lam, commonly known as a tomatillo, is a staple of the Mesoamerican cuisine. In our laboratory, an ethyl acetate‐soluble extract and…”
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Aromatase Inhibitors from Broussonetia papyrifera by LEE, Dongho, BHAT, Krishna P. L., FONG, Harry H. S., FARNSWORTH, Norman R., PEZZUTO, John M., KINGHORN, A. Douglas

“…Bioassay-guided fractionation of an ethyl acetate-soluble extract from the whole plants of Broussonetia papyrifera, using an in vitro aromatase inhibition…”
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Three New Sesquiterpene Glycosides from Dendrobium nobile with Immunomodulatory Activity by ZHAO, Weimin, YE, Qinghua, TAN, Xiaojian, JIANG, Hualiang, LI, Xiaoyu, CHEN, Kaixian, KINGHORN, A. Douglas

“…Dendroside A (1) and dendronobilosides A and B (2 and 3), three new sesquiterpene glycosides, have been isolated from the stems of Dendrobium nobile, a plant…”
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Antioxidant Flavonoid Glycosides from Daphniphyllum calycinum by Gamez, Esperanza J. C, Luyengi, Lumonadio, Lee, Sang Kook, Zhu, Liang-Feng, Zhou, Bing-Nan, Fong, Harry H. S, Pezzuto, John M, Kinghorn, A. Douglas

“…A novel flavonoid diglycoside, 5,6,7,4‘-tetrahydroxyflavonol 3-O-rutinoside (1), and a previously known compound, kaempferol 3-O-neohesperidoside (2), were…”
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Novel strategies for the discovery of plant-derived anticancer agents by Kinghorn, A. D., Farnsworth, Norman R., Soejarto, D. D., Cordell, G. A., Pezzuto, J. M., Udeani, G. O., Wani, M. C., Wall, M. E., Navarro, H. A., Kramer, R. A., Menendez, A. T., Fairchild, Craig R., Lane, K. E., Forenza, Salvatore, Vyas, D. M., Lam, K. S., Shu, Y.-Z.

“…Abstract…”
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Activity-Guided Isolation of Antioxidative Constituents of Cotinus coggygria by WESTENBURG, Hans E., LEE, Kon-Joo, LEE, Sang Kook, FONG, Harry H. S., VAN BREEMEN, Richard B., PEZZUTO, John M., KINGHORN, A. Douglas

“…Six constituents (1-6) were isolated from EtOAc-soluble partitions of two separate collections of the whole plants of Cotinus coggygria, namely, disulfuretin…”
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Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model by Suh, N, Luyengi, L, Fong, H H, Kinghorn, A D, Pezzuto, J M

“…Terminal differentiation of human promyelocytic leukemia (HL-60) cells can be induced by a variety of chemical agents and this process can be monitored readily…”
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Ten Years OnA Decade of Progress by Kinghorn, A. D

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Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity by Callahan, K P, Minhajuddin, M, Corbett, C, Lagadinou, E D, Rossi, R M, Grose, V, Balys, M M, Pan, L, Jacob, S, Frontier, A, Grever, M R, Lucas, D M, Kinghorn, A D, Liesveld, J L, Becker, M W, Jordan, C T

“…Identification of agents that target human leukemia stem cells is an important consideration for the development of new therapies. The present study…”
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Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid by UDEANI, G. O, GERHÄUSER, C, THOMAS, C. F, MOON, R. C, KOSMEDER, J. W, KINGHORN, A. D, MORIARTY, R. M, PEZZUTO, J. M

“…Deguelin, a natural product isolated from Mundulea sericea (Leguminosae), was shown previously to mediate strong inhibition of…”
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Bioactive Constituents of Thuja occidentalis by CHANG, Leng Chee, SONG, Lynda L., PARK, Eun Jung, LUYENGI, Lumonadio, LEE, Kon Joo, FARNSWORTH, Norman R., PEZZUTO, John M., KINGHORN, A. Douglas

“…An ethyl acetate-soluble extract of the combined leaves and twigs of Thuja occidentalis was found to inhibit 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced…”
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Cytostatic mechanism and antitumor potential of novel 1H-cyclopenta[b]benzofuran lignans isolated from Aglaia elliptica by Lee, S K, Cui, B, Mehta, R R, Kinghorn, A D, Pezzuto, J M

“…A total of five 1H-cyclopenta[b]benzofuran lignans (1-5) isolated from the stems of Aglaia elliptica B1. (Meliaceae) inhibited the growth of human cancer cells…”
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Macharistol, a New Cytotoxic Cinnamylphenol from the Stems of Machaerium aristulatum by SEO, Eun-Kyoung, KIM, Nam-Cheol, MI, Qiuwen, CHAI, Heebyung, WALL, Monroe E., WANI, Mansukh C., NAVARRO, Hernán A., BURGESS, Jason P., GRAHAM, James G., CABIESES, Fernando, TAN, Ghee T., FARNSWORTH, Norman R., PEZZUTO, John M., KINGHORN, A. Douglas

“…A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium…”
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Flavonoid Constituents of Chorizanthe diffusa with Potential Cancer Chemopreventive Activity by Chung, Ha Sook, Chang, Leng Chee, Lee, Sang Kook, Shamon, Lisa A, van Breemen, Richard B, Mehta, Rajendra G, Farnsworth, Norman R, Pezzuto, John M, Kinghorn, A. Douglas

“…An ethyl acetate-soluble extract of Chorizanthe diffusa was found to exhibit significant antioxidant activity, as judged by scavenging stable…”
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Cytotoxic prenylated flavanones from Monotes engleri by Seo, E.-K., Silva, G.L., Chai, H.-B., Chagwedera, T.E., Farnsworth, N.R., Cordell, G.A., Pezzuto, J.M., Kinghorn, A.D.

“…From the leaves of Monotes engleri, five prenylated flavanones were isolated as constituents that displayed cytotoxic activity against several human cancer…”
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Activity-Guided Isolation of Constituents of Tephrosia purpurea with the Potential to Induce the Phase II Enzyme, Quinone Reductase by Chang, Leng Chee, Gerhäuser, Clarissa, Song, Lynda, Farnsworth, Norman R, Pezzuto, John M, Kinghorn, A. Douglas

“…An isoflavone, 7,4‘-dihydroxy-3‘,5‘-dimethoxyisoflavone (1), and a chalcone, (+)-tephropurpurin (2), both novel compounds, as well as six constituents of known…”
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Evaluation of Natural Products as Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase by Tan, Ghee T, Pezzuto, John M, Kinghorn, A. Douglas, Hughes, Stephen H

“…Inhibition of human immunodeficiency virus reverse transcriptase is currently considered a useful approach in the prophylaxis and intervention of acquired…”
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Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells by Mata-Greenwood, E, Ito, A, Westenburg, H, Cui, B, Mehta, R G, Kinghorn, A D, Pezzuto, J M

“…Non-physiological inducers of terminal differentiation have been used as novel therapies for the prevention and therapy of cancer. We have used cultured HL-60…”
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Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal by Wall, M.E., Wani, M.C., Brown, D.M., Fullas, F., Olwald, J.B., Josephson, F.F., Thornton, N.M., Pezzuto, J.M., Beecher, C.W.W., Farnsworth, N.R., Cordell, G.A., Kinghorn, A.D.

“…Ethyl acetate and aqueous extracts of tannin-containing topoisomerase inhibitory plant samples were subjected to one or more of seven tannin removal…”
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Cytotoxic Polyacetylenes from the Twigs of Ochanostachys amentacea by ITO, Aiko, CUI, Baoliang, CHáVEZ, Daniel, CHAI, Hee-Byung, SHIN, Young Geun, KAWANISHI, Kazuko, KARDONO, Leonardus B. S., RISWAN, Soedarsono, FARNSWORTH, Norman R., CORDELL, Geoffrey A., PEZZUTO, John M., KINGHORN, A. Douglas

“…Bioassay-guided investigation of the twigs of Ochanostachys amentacea using LNCaP (hormone-dependent human prostate cancer) cells as a monitor led to the…”
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