Search Results - "King, Rhodri"

Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk by King, Rhodri J, Schuett, Katharina, Tiede, Christian, Jankowski, Vera, John, Vicky, Trehan, Abhi, Simmons, Katie, Ponnambalam, Sreenivasan, Storey, Robert F, Fishwick, Colin WG, McPherson, Michael J, Tomlinson, Darren C, Ajjan, Ramzi A

“…Complement C3 binds fibrinogen and compromises fibrin clot lysis thereby enhancing thrombosis risk. We investigated the role of fibrinogen-C3 interaction as a…”
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Vascular risk in obesity: Facts, misconceptions and the unknown by King, Rhodri J, Ajjan, Ramzi A

“…Obesity is a major burden on healthcare systems worldwide due to the association with numerous complications, arguably the most important of which are the…”
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Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications by Kearney, Katherine J., Pechlivani, Nikoletta, King, Rhodri, Tiede, Christian, Phoenix, Fladia, Cheah, Ramsah, Macrae, Fraser L., Simmons, Katie J., Manfield, Iain W., Smith, Kerrie A., Spurgeon, Benjamin E.J., Naseem, Khalid M., Ariens, Robert A.S., McPherson, Michael J., Tomlinson, Darren C., Ajjan, Ramzi A.

“…Bleeding complications secondary to surgery, trauma, or coagulation disorders are important causes of morbidity and mortality. Although fibrin sealants are…”
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Inhibition of complement C3 and fibrinogen interaction: a potential novel therapeutic target to reduce cardiovascular disease in diabetes by King, Rhodri, Dr, Tiede, Christian, PhD, Simmons, Katie, PhD, Fishwick, Colin, Prof, Tomlinson, Darren, PhD, Ajjan, Ramzi, MD

“…Abstract Background Enhanced complement C3 incorporation into the fibrin network in diabetes is one mechanism for impaired fibrinolysis and increased…”
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Hypofibrinolysis in type 2 diabetes: the role of the inflammatory pathway and complement C3 by HESS, Katharina, ALZAHRANI, Saad H, PRICE, Jackie F, STRACHAN, Mark W, OXLEY, Natalie, KING, Rhodri, GAMLEN, Tobias, SCHROEDER, Verena, BAXTER, Paul D, AJJAN, Ramzi A

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Hybrid Closed Loop Therapy in Adults With Type 1 Diabetes and Above-Target HbA1c: A Real-World Observational Study by Crabtree, Thomas S J, Griffin, Tomás P, Yap, Yew W, Narendran, Parth, Gallen, Geraldine, Furlong, Niall, Cranston, Iain, Chakera, Ali, Philbey, Chris, Karamat, Muhammad Ali, Saraf, Sanjay, Kamaruddin, Shafie, Gurnell, Eleanor, Chapman, Alyson, Hussain, Sufyan, Elliott, Jackie, Leelarathna, Lalantha, Ryder, Robert E J, Hammond, Peter, Lumb, Alistair, Choudhary, Pratik, Wilmot, Emma G

“…We explored longitudinal changes associated with switching to hybrid closed loop (HCL) insulin delivery systems in adults with type 1 diabetes and elevated…”
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Hypofibrinolysis in type 2 diabetes: the role of the inflammatory pathway and complement C3 by Hess, Katharina, Alzahrani, Saad H., Price, Jackie F., Strachan, Mark W., Oxley, Natalie, King, Rhodri, Gamlen, Tobias, Schroeder, Verena, Baxter, Paul D., Ajjan, Ramzi A.

“…Aims/hypothesis Plasminogen activator inhibitor-1 (PAI-1) has been regarded as the main antifibrinolytic protein in diabetes, but recent work indicates that…”
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Changes in fibrin clot properties in patients after Roux-en-Y gastric bypass surgery by Abbas, Kazim, Hierons, Stephen J., Pechlivani, Nikoletta, Phoenix, Fladia, Alexander, Robin, King, Rhodri, Ajjan, Ramzi A., Stewart, Alan J.

“…Obesity is a complex condition associated with prothrombotic fibrin networks that are resistant to fibrinolysis. Altered fibrin clot properties enhance…”
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Do diabetes trainees have an appetite for bariatric medicine? by King, Rhodri, Rajeswaran, Chinnadorai, Wass, John

“…Letters not directly related to articles published in Clinical Medicine and presenting unpublished original data should be submitted for publication in this…”
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Effects of dabigatran on the cellular and protein phase of coagulation in patients with coronary artery disease on dual antiplatelet therapy with aspirin and clopidogrel. Results from a prospective, randomised, double-blind, placebo-controlled study by Franchi, Francesco, Rollini, Fabiana, Cho, Jung Rae, King, Rhodri, Phoenix, Fladia, Bhatti, Mona, DeGroat, Christopher, Tello-Montoliu, Antonio, Zenni, Martin M, Guzman, Luis A, Bass, Theodore A, Ajjan, Ramzi A, Angiolillo, Dominick J

“…There is growing interest in understanding the effects of adding an oral anticoagulant in patients on dual antiplatelet therapy (DAPT). Vitamin K antagonists…”
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The fibrin network in diabetes: its role in thrombosis risk by Kurdee, Zeyad, King, Rhodri, Ajjan, Ramzi A

“…Despite advances in therapy, individuals with diabetes remain at high risk of cardiovascular disease and their clinical prognosis following vascular ischemia…”
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Abstract 16668: The Effects of Dabigatran on Fibrin Network Structure and Lysis: A Simple Technique to Monitor Efficacy of Treatment? by Franchi, Francesco, King, Rhodri, Phoenix, Fladia, Rollini, Fabiana, Cho, Jung Rae, Bhatti, Mona, DeGroat, Christopher, Tello-Montoliu, Antonio, Duarte, Valeria, Thano, Estela, Faz, Gabriel, Zenni, Martin M, Guzman, Luis A, Bass, Theodore A, Angiolillo, Dominick J, Ajjan, Ramzi

“…Abstract only Background: Thrombus formation represent the final step in the atherothrombotic process and occurs secondary to a complex interaction between…”
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Patients with morbid obesity should not be routinely screened for Cushing's syndrome: Results of retrospective study of patients attending a specialist weight management service by Glyn, Tessa Carlin, Ho, May Wai‐Jing, Lambert, Anthony Paul, Thomas, Julia Dominique Janine, Douek, Isabelle Francoise, Andrews, Robert Charles, King, Rhodri James

“…Summary Cushing's syndrome (CS) is a rare condition which results in multi‐system involvement and can lead to significant morbidity and mortality. Screening…”
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The role of complement c3 in diabetes by King, Rhodri James

“…The prevalence of diabetes worldwide continues to rise and with it the burden of cardiovascular disease (CVD). This is related to clustering of cardiovascular…”
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