Search Results - "King, Nicholas JC"

Inflammatory monocytes and the pathogenesis of viral encephalitis by Terry, Rachael L, Getts, Daniel R, Deffrasnes, Celine, van Vreden, Caryn, Campbell, Iain L, King, Nicholas J C

“…Monocytes are a heterogeneous population of bone marrow-derived cells that are recruited to sites of infection and inflammation in many models of human…”
Get full text

Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection by Oliver, Brian G G, Johnston, Sebastian L, Baraket, Melissa, Burgess, Janette K, King, Nicholas J C, Roth, Michael, Lim, Sam, Black, Judith L

“…Exacerbations of asthma are associated with viral respiratory tract infections, of which rhinoviruses (RV) are the predominant virus type. Airway smooth muscle…”
Get full text

Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages by Getts, Daniel R, Terry, Rachael L, Getts, Meghann Teague, Müller, Marcus, Rana, Sabita, Deffrasnes, Celine, Ashhurst, Thomas Myles, Radford, Jane, Hofer, Markus, Thomas, Shane, Campbell, Iain L, King, Nicholas J C

“…Infiltration of Ly6C(hi) monocytes from the blood is a hallmark of viral encephalitis. In mice with lethal encephalitis caused by West Nile virus (WNV), an…”
Get full text

Harnessing nanoparticles for immune modulation by Getts, Daniel R, Shea, Lonnie D, Miller, Stephen D, King, Nicholas J.C

“…Highlights • NPs can be generated from numerous biocompatible compounds. • Specific physiochemical characteristics can be manipulated to modulate the immune…”
Get full text

Fc receptors in antibody-dependent enhancement of viral infections by Taylor, Adam, Foo, Suan-Sin, Bruzzone, Roberto, Vu Dinh, Luan, King, Nicholas J. C., Mahalingam, Suresh

“…Summary Sensitization of the humoral immune response to invading viruses and production of antiviral antibodies forms part of the host antiviral repertoire…”
Get full text

Regulation of cellular adhesion molecule expression in murine oocytes,peri-implantation and post-implantation embryos by Lu, David P, Tian, Lina, O'Neill, Chris, King, Nicholas J C

“…Expression of the adhesion molecules, ICAM-1, VCAM-1, NCAM, CD44, CD49d (VLA-4, α chain) ,and CDlla (LFA-1, α chain) on mouse oocytes, and pre- and…”
Get full text

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis by Getts, Daniel R, Martin, Aaron J, McCarthy, Derrick P, Terry, Rachael L, Hunter, Zoe N, Yap, Woon Teck, Getts, Meghann Teague, Pleiss, Michael, Luo, Xunrong, King, Nicholas JC, Shea, Lonnie D, Miller, Stephen D

“…Microparticles coated with encephalitogenic peptides are effective at treating multiple sclerosis in a mouse model. Aberrant T-cell activation underlies many…”
Get full text

Diet, commensal microbiota‐derived extracellular vesicles, and host immunity by Taitz, Jemma J, Tan, Jian K, Potier‐Villette, Camille, Ni, Duan, King, Nicholas JC, Nanan, Ralph, Macia, Laurence

“…The gut microbiota has co‐evolved with its host, and commensal bacteria can influence both the host's immune development and function. Recently, a role has…”
Get full text

Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells by Getts, Daniel R, Turley, Danielle M, Smith, Cassandra E, Harp, Christopher T, McCarthy, Derrick, Feeney, Emma M, Getts, Meghann Teague, Martin, Aaron J, Luo, Xunrong, Terry, Rachael L, King, Nicholas J C, Miller, Stephen D

“…Ag-specific tolerance is a highly desired therapy for immune-mediated diseases. Intravenous infusion of protein/peptide Ags linked to syngeneic splenic…”
Get full text

NK cell profiling in West Nile virus encephalitis reveals potential metabolic basis for functional inhibition by Spiteri, Alanna G, Wishart, Claire L, Pinget, Gabriela V, Purohit, Shivam K, Macia, Laurence, King, Nicholas JC, Niewold, Paula

“…Natural killer (NK) cells are cytotoxic lymphocytes important for viral defense. West Nile virus (WNV) infection of the central nervous system (CNS) causes…”
Get full text

ChronoClust: Density-based clustering and cluster tracking in high-dimensional time-series data by Putri, Givanna H., Read, Mark N., Koprinska, Irena, Singh, Deeksha, Röhm, Uwe, Ashhurst, Thomas M., King, Nicholas J.C.

“…In many scientific disciplines, the advent of new high-throughput technologies is giving rise to vast quantities of high-dimensional time-series data. A common…”
Get full text

Zika Virus: Mechanisms of Infection During Pregnancy by King, Nicholas J.C, Teixeira, Mauro M, Mahalingam, Suresh

“…Immune status changes during pregnancy, with pro-inflammatory and anti-inflammatory contexts at different stages, making pregnant women potentially more…”
Get full text

IL-22 and non-ELR-CXC chemokine expression in chronic hepatitis B virus-infected liver by Xiang, Xiaogang, Gui, Honglian, King, Nicholas JC, Cole, Louise, Wang, Hui, Xie, Qing, Bao, Shisan

“…Hepatitis B virus infection is still a major global health problem, despite decades of research. Interleukin (IL)‐22 induces acute phase reactants and…”
Get full text

Accelerated Dendritic Cell Differentiation from Migrating Ly6Clo Bone Marrow Monocytes in Early Dermal West Nile Virus Infection by Davison, Ariane M., King, Nicholas J. C.

“…Abstract No study has investigated the participation of Ly6C+ monocytes in the earliest phase of skin infection with the mosquito-borne West Nile virus. In a…”
Get full text

CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System by Muller, Marcus, Carter, Sally L, Hofer, Markus J, Manders, Peter, Getts, Daniel R, Getts, Meghan T, Dreykluft, Angela, Lu, Bao, Gerard, Craig, King, Nicholas J. C, Campbell, Iain L

“…The chemokine receptor CXCR3 promotes the trafficking of activated T and NK cells in response to three ligands, CXCL9, CXCL10, and CXCL11. Although these…”
Get full text

Entry of herpes simplex virus type 1 (HSV-1) into the distal axons of trigeminal neurons favors the onset of nonproductive, silent infection by Hafezi, Wali, Lorentzen, Eva U, Eing, Bodo R, Müller, Marcus, King, Nicholas J C, Klupp, Barbara, Mettenleiter, Thomas C, Kühn, Joachim E

“…Following productive, lytic infection in epithelia, herpes simplex virus type 1 (HSV-1) establishes a lifelong latent infection in sensory neurons that is…”
Get full text

Harnessing Nanoparticles for Immune Modulation: Trends in Immunology 36, 419-427; July 2016 by Getts, Daniel R, Shea, Lonnie D, Miller, Stephen D, King, Nicholas JC

“…Condition Animal model Species Outcome Refs Acute myocardial infarction Temporary LAD occlusionComplete LAD occlusion MouseMouse Reduced inflammation, reduced…”
Get full text

Harnessing Nanoparticles for Immune Modulation by Getts, Daniel R, Shea, Lonnie D, Miller, Stephen D, King, Nicholas J.C

Get full text

Redox Control of the Critical Immune Regulatory Enzyme Indoleamine 2,3-Dioxygenase by NADPH Oxidase 2-Derived Reactive Oxygen Species in Human Monocytes by Yeung, Amanda WS, Lim, Yean J, Hastad, Maria, Dang, Lei, Örfi, László, Szabadkai, István, Kéri, György, Terentis, Andrew C, King, Nicholas JC, Witting, Paul K, Thomas, Shane R

Get full text

121 - Redox Control of the Critical Immune Regulatory Enzyme Indoleamine 2,3-Dioxygenase by NADPH Oxidase 2-Derived Reactive Oxygen Species in Human Monocytes by Yeung, Amanda WS, Lim, Yean J, Hastad, Maria, Dang, Lei, Örfi, László, Szabadkai, István, Kéri, György, Terentis, Andrew C, King, Nicholas JC, Witting, Paul K, Thomas, Shane R

“…The heme enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is a critical immune regulatory enzyme capable of signalling for immune suppression in diverse…”
Get full text