Search Results - "King, Nicholas"

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function by Spiteri, Alanna G., Wishart, Claire L., Pamphlett, Roger, Locatelli, Giuseppe, King, Nicholas J. C.

“…In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS parenchyma, may diverge from, or intersect with, those of recruited…”
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Fc receptors in antibody-dependent enhancement of viral infections by Taylor, Adam, Foo, Suan-Sin, Bruzzone, Roberto, Vu Dinh, Luan, King, Nicholas J. C., Mahalingam, Suresh

“…Summary Sensitization of the humoral immune response to invading viruses and production of antiviral antibodies forms part of the host antiviral repertoire…”
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Harnessing nanoparticles for immune modulation by Getts, Daniel R, Shea, Lonnie D, Miller, Stephen D, King, Nicholas J.C

“…Highlights • NPs can be generated from numerous biocompatible compounds. • Specific physiochemical characteristics can be manipulated to modulate the immune…”
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Role of indoleamine 2,3-dioxygenase in health and disease by Yeung, Amanda W S, Terentis, Andrew C, King, Nicholas J C, Thomas, Shane R

“…IDO1 (indoleamine 2,3-dioxygenase 1) is a member of a unique class of mammalian haem dioxygenases that catalyse the oxidative catabolism of the least-abundant…”
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Designing drug-free biodegradable nanoparticles to modulate inflammatory monocytes and neutrophils for ameliorating inflammation by Saito, Eiji, Kuo, Robert, Pearson, Ryan M., Gohel, Nishant, Cheung, Brandon, King, Nicholas J.C., Miller, Stephen D., Shea, Lonnie D.

“…Inflammation associated with autoimmune diseases and chronic injury is an initiating event that leads to tissue degeneration and dysfunction. Inflammatory…”
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Declining Life Expectancy in the United States: Missing the Trees for the Forest by Harper, Sam, Riddell, Corinne A, King, Nicholas B

“…In recent years, life expectancy in the United States has stagnated, followed by three consecutive years of decline. The decline is small in absolute terms but…”
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Can live-attenuated SARS-CoV-2 vaccine contribute to stopping the pandemic? by Tang, Patrick Chun Hean, Ng, Wern Hann, King, Nicholas J C, Mahalingam, Suresh

“…There is a small number of other reported LAV that have shown utility in animal models of COVID-19 [3,4], such as a temperature-sensitive Severe Acute…”
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Determinants of increased opioid-related mortality in the United States and Canada, 1990-2013: a systematic review by King, Nicholas B, Fraser, Veronique, Boikos, Constantina, Richardson, Robin, Harper, Sam

“…We review evidence of determinants contributing to increased opioid-related mortality in the United States and Canada between 1990 and 2013. We identified 17…”
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Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis by Getts, Daniel R, Martin, Aaron J, McCarthy, Derrick P, Terry, Rachael L, Hunter, Zoe N, Yap, Woon Teck, Getts, Meghann Teague, Pleiss, Michael, Luo, Xunrong, King, Nicholas JC, Shea, Lonnie D, Miller, Stephen D

“…Microparticles coated with encephalitogenic peptides are effective at treating multiple sclerosis in a mouse model. Aberrant T-cell activation underlies many…”
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Aluminum for Plasmonics by Knight, Mark W, King, Nicholas S, Liu, Lifei, Everitt, Henry O, Nordlander, Peter, Halas, Naomi J

“…Unlike silver and gold, aluminum has material properties that enable strong plasmon resonances spanning much of the visible region of the spectrum and into the…”
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Inflammatory monocytes and the pathogenesis of viral encephalitis by Terry, Rachael L, Getts, Daniel R, Deffrasnes, Celine, van Vreden, Caryn, Campbell, Iain L, King, Nicholas J C

“…Monocytes are a heterogeneous population of bone marrow-derived cells that are recruited to sites of infection and inflammation in many models of human…”
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Contribution of STAT1 to innate and adaptive immunity during type I interferon-mediated lethal virus infection by Jung, So Ri, Ashhurst, Thomas M, West, Phillip K, Viengkhou, Barney, King, Nicholas J C, Campbell, Iain L, Hofer, Markus J

“…Signal transducers and activators of transcription (STAT) 1 is critical for cellular responses to type I interferons (IFN-Is), with the capacity to determine…”
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IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS by Minten, Carsten, Terry, Rachael, Deffrasnes, Celine, King, Nicholas J C, Campbell, Iain L

“…IFN regulatory factor (IRF) 8 is a transcription factor that has a key role in the cellular response to IFN-γ and is pivotal in myeloid cell differentiation…”
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Fano Resonant Aluminum Nanoclusters for Plasmonic Colorimetric Sensing by King, Nicholas S, Liu, Lifei, Yang, Xiao, Cerjan, Benjamin, Everitt, Henry O, Nordlander, Peter, Halas, Naomi J

“…Aluminum is an abundant and high-quality material for plasmonics with potential for large-area, low-cost photonic technologies. Here we examine aluminum…”
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The role of CXCR3 in DSS-induced colitis by Chami, Belal, Yeung, Amanda W S, van Vreden, Caryn, King, Nicholas J C, Bao, Shisan

“…Inflammatory bowel disease (IBD) is a group of disorders that are characterized by chronic, uncontrolled inflammation in the intestinal mucosa. Although the…”
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Untreated pain, narcotics regulation, and global health ideologies by King, Nicholas B, Fraser, Veronique

“…Pain management is marginalized or ignored, with millions of people worldwide unnecessarily living with untreated pain. Reducing global inequalities in…”
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Cash transfer programs have differential effects on health: A review of the literature from low and middle-income countries by Cooper, Jan E., Benmarhnia, Tarik, Koski, Alissa, King, Nicholas B.

“…Cash transfer programs have grown increasingly popular and are now used as interventions to target a wide array of health outcomes across many diverse…”
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Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease by Freitag, Tobias L., Podojil, Joseph R., Pearson, Ryan M., Fokta, Frank J., Sahl, Cecilia, Messing, Marcel, Andersson, Leif C., Leskinen, Katarzyna, Saavalainen, Päivi, Hoover, Lisa I., Huang, Kelly, Phippard, Deborah, Maleki, Sanaz, King, Nicholas J.C., Shea, Lonnie D., Miller, Stephen D., Meri, Seppo K., Getts, Daniel R.

“…Celiac disease could be treated, and potentially cured, by restoring T-cell tolerance to gliadin. We investigated the safety and efficacy of negatively charged…”
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Entry of herpes simplex virus type 1 (HSV-1) into the distal axons of trigeminal neurons favors the onset of nonproductive, silent infection by Hafezi, Wali, Lorentzen, Eva U, Eing, Bodo R, Müller, Marcus, King, Nicholas J C, Klupp, Barbara, Mettenleiter, Thomas C, Kühn, Joachim E

“…Following productive, lytic infection in epithelia, herpes simplex virus type 1 (HSV-1) establishes a lifelong latent infection in sensory neurons that is…”
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Ocular tropism of SARS-CoV-2 in animal models with retinal inflammation via neuronal invasion following intranasal inoculation by Jeong, Gi Uk, Kwon, Hyung-Jun, Ng, Wern Hann, Liu, Xiang, Moon, Hyun Woo, Yoon, Gun Young, Shin, Hye Jin, Lee, In-Chul, Ling, Zheng Lung, Spiteri, Alanna G., King, Nicholas J. C., Taylor, Adam, Chae, Ji Soo, Kim, Chonsaeng, Ahn, Dae-Gyun, Kim, Kyun-Do, Ryu, Young Bae, Kim, Seong-Jun, Mahalingam, Suresh, Kwon, Young-Chan

“…Although ocular manifestations are reported in patients with COVID-19, consensus on ocular tropism of SARS-CoV-2 is lacking. Here, we infect K18-hACE2…”
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