Search Results - "King, Lorraine M."

Minimal barriers to invasion during human colorectal tumor growth by Ryser, Marc D., Mallo, Diego, Hall, Allison, Hardman, Timothy, King, Lorraine M., Tatishchev, Sergei, Sorribes, Inmaculada C., Maley, Carlo C., Marks, Jeffrey R., Hwang, E. Shelley, Shibata, Darryl

“…Intra-tumoral heterogeneity (ITH) could represent clonal evolution where subclones with greater fitness confer more malignant phenotypes and invasion…”
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Prediction of Occult Invasive Disease in Ductal Carcinoma in Situ Using Deep Learning Features by Shi, Bibo, Grimm, Lars J., Mazurowski, Maciej A., Baker, Jay A., Marks, Jeffrey R., King, Lorraine M., Maley, Carlo C., Hwang, E. Shelley, Lo, Joseph Y.

“…The aim of this study was to determine whether deep features extracted from digital mammograms using a pretrained deep convolutional neural network are…”
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Can Occult Invasive Disease in Ductal Carcinoma In Situ Be Predicted Using Computer-extracted Mammographic Features? by Shi, Bibo, PhD, Grimm, Lars J., MD, MHS, Mazurowski, Maciej A., PhD, Baker, Jay A., MD, Marks, Jeffrey R., PhD, King, Lorraine M., PhD, Maley, Carlo C., PhD, Hwang, E. Shelley, MD, MPH, Lo, Joseph Y., PhD

“…Rationale and Objectives This study aimed to determine whether mammographic features assessed by radiologists and using computer algorithms are prognostic of…”
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Spatial interplay of tissue hypoxia and T-cell regulation in ductal carcinoma in situ by Sobhani, Faranak, Muralidhar, Sathya, Hamidinekoo, Azam, Hall, Allison H., King, Lorraine M., Marks, Jeffrey R., Maley, Carlo, Horlings, Hugo M., Hwang, E. Shelley, Yuan, Yinyin

“…Hypoxia promotes aggressive tumor phenotypes and mediates the recruitment of suppressive T cells in invasive breast carcinomas. We investigated the role of…”
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Cloning of CYP2J2 gene and identification of functional polymorphisms by King, Lorraine M, Ma, Jixiang, Srettabunjong, Supawon, Graves, Joan, Bradbury, J Alyce, Li, Leping, Spiecker, Martin, Liao, James K, Mohrenweiser, Harvey, Zeldin, Darryl C

“…CYP2J2 is abundant in cardiovascular tissue and active in the metabolism of arachidonic acid to eicosanoids that possess potent anti-inflammatory,…”
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Prediction of Upstaging in Ductal Carcinoma in Situ Based on Mammographic Radiomic Features by Hou, Rui, Grimm, Lars J, Mazurowski, Maciej A, Marks, Jeffrey R, King, Lorraine M, Maley, Carlo C, Lynch, Thomas, van Oirsouw, Marja, Rogers, Keith, Stone, Nicholas, Wallis, Matthew, Teuwen, Jonas, Wesseling, Jelle, Hwang, E Shelley, Lo, Joseph Y

“…Background Improving diagnosis of ductal carcinoma in situ (DCIS) before surgery is important in choosing optimal patient management strategies. However,…”
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Anomaly Detection of Calcifications in Mammography Based on 11,000 Negative Cases by Hou, Rui, Peng, Yifan, Grimm, Lars J., Ren, Yinhao, Mazurowski, Maciej A., Marks, Jeffrey R., King, Lorraine M., Maley, Carlo C., Hwang, E. Shelley, Lo, Joseph Y.

“…In mammography, calcifications are one of the most common signs of breast cancer. Detection of such lesions is an active area of research for computer-aided…”
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Archival single-cell genomics reveals persistent subclones during DCIS progression by Wang, Kaile, Kumar, Tapsi, Wang, Junke, Minussi, Darlan Conterno, Sei, Emi, Li, Jianzhuo, Tran, Tuan M., Thennavan, Aatish, Hu, Min, Casasent, Anna K., Xiao, Zhenna, Bai, Shanshan, Yang, Lei, King, Lorraine M., Shah, Vandna, Kristel, Petra, van der Borden, Carolien L., Marks, Jeffrey R., Zhao, Yuehui, Zurita, Amado J., Aparicio, Ana, Chapin, Brian, Ye, Jie, Zhang, Jianjun, Gibbons, Don L., Sawyer, Ellinor, Thompson, Alastair M., Futreal, Andrew, Hwang, E. Shelley, Wesseling, Jelle, Lips, Esther H., Navin, Nicholas E.

“…Ductal carcinoma in situ (DCIS) is a common precursor of invasive breast cancer. Our understanding of its genomic progression to recurrent disease remains…”
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Prediction of Upstaged Ductal Carcinoma In Situ Using Forced Labeling and Domain Adaptation by Hou, Rui, Mazurowski, Maciej A., Grimm, Lars J., Marks, Jeffrey R., King, Lorraine M., Maley, Carlo C., Hwang, Eun-Sil Shelley, Lo, Joseph Y.

“…Objective: The goal of this study is to use adjunctive classes to improve a predictive model whose performance is limited by the common problems of small…”
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A new method to accurately identify single nucleotide variants using small FFPE breast samples by Fortunato, Angelo, Mallo, Diego, Rupp, Shawn M, King, Lorraine M, Hardman, Timothy, Lo, Joseph Y, Hall, Allison, Marks, Jeffrey R, Hwang, E Shelley, Maley, Carlo C

“…Most tissue collections of neoplasms are composed of formalin-fixed and paraffin-embedded (FFPE) excised tumor samples used for routine diagnostics. DNA…”
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Characterization and clinical validation of MCM2 and TOP2A monoclonal antibodies in the BD ProEx™ C assay: An immunoassay which detects aberrant S-phase induction in cervical tissue by Dixon, Eric P., King, Lorraine M., Nelson, Ramona, Simkins, Stephen G., Knapp, Steven L., Brough, George H., Lenz, Karen L., Henderson, Dorian T., Whitehead, Clark M., Hessling, Janice, Brown, Charlotte A., Malinowski, Douglas P.

“…The Papanicolaou (Pap) screen has been successful in reducing cervical cancer; but exhibits low sensitivity when detecting cervical dysplasia. Use of molecular…”
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Single nucleotide polymorphisms in the CYP2J2 and CYP2C8 genes and the risk of hypertension by King, Lorraine M, Gainer, James V, David, Gloria L, Dai, Ding, Goldstein, Joyce A, Brown, Nancy J, Zeldin, Darryl C

“…CYP2J2 and CYP2C8 metabolize arachidonic acid (AA) to cis-epoxyeicosatrienoic acids (EETs), which play a central role in regulating renal tubular…”
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Analytical performance of RNA isolated from BD SurePath™ cervical cytology specimens by the PreTect™ HPV-Proofer assay by Dixon, Eric P., Grønn, Petter, King, Lorraine M., Passineau, Heather, Doobay, Hema, Skomedal, Hanne, Hariri, Jalil, Hay, Shauna N., Brown, Charlotte A., Fischer, Timothy J., Malinowski, Douglas P.

“…► RNA isolated from BD SurePath™ LBC is compatible with the ancillary PreTect™ HPV-Proofer assay. ► RNA was found to be stable for a minimum of 21 days when…”
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Functional characterization of cyclooxygenase-2 polymorphisms by Fritsche, E, Baek, S J, King, L M, Zeldin, D C, Eling, T E, Bell, D A

“…Cyclooxygenases (COX)-1 and -2 are the key enzymes in the conversion of arachidonic acid to prostaglandins. COX-2 appears to play an emerging role in…”
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Isolation of RNA from cell lines and cervical cytology specimens stored in BD SurePath™ preservative fluid and downstream detection of housekeeping gene and HPV E6 expression using real time RT-PCR by Murphy, Patricia G., Henderson, Dorian T., Adams, Melissa D., Horlick, Elizabeth A., Dixon, Eric P., King, Lorraine M., Avissar, Patricia L., Brown, Charlotte A., Fischer, Timothy J., Malinowski, Douglas P.

“…This study was performed to demonstrate that RNA isolated from cell lines and cervical cytology specimens stored in SurePath™ preservative fluid would be…”
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Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts by Strand, Siri H., Rivero-Gutiérrez, Belén, Houlahan, Kathleen E., Seoane, Jose A., King, Lorraine M., Risom, Tyler, Simpson, Lunden A., Vennam, Sujay, Khan, Aziz, Cisneros, Luis, Hardman, Timothy, Harmon, Bryan, Couch, Fergus, Gallagher, Kristalyn, Kilgore, Mark, Wei, Shi, DeMichele, Angela, King, Tari, McAuliffe, Priscilla F., Nangia, Julie, Lee, Joanna, Tseng, Jennifer, Storniolo, Anna Maria, Thompson, Alastair M., Gupta, Gaorav P., Burns, Robyn, Veis, Deborah J., DeSchryver, Katherine, Zhu, Chunfang, Matusiak, Magdalena, Wang, Jason, Zhu, Shirley X., Tappenden, Jen, Ding, Daisy Yi, Zhang, Dadong, Luo, Jingqin, Jiang, Shu, Varma, Sushama, Anderson, Lauren, Straub, Cody, Srivastava, Sucheta, Curtis, Christina, Tibshirani, Rob, Angelo, Robert Michael, Hall, Allison, Owzar, Kouros, Polyak, Kornelia, Maley, Carlo, Marks, Jeffrey R., Colditz, Graham A., Hwang, E. Shelley, West, Robert B.

“…Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale,…”
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Abstract PR02: Inferring the evolutionary dynamics of ductal carcinoma in situ through multi-regional sequencing and mathematical modeling by Ryser, Marc D., Sorribes, Inmaculada C., Greenwald, Matthew, Wu, Ethan, Hall, Allison, Mallo, Diego, King, Lorraine M., Hardman, Timothy, Simpson, Lunden, Maley, Carlo C., Marks, Jeffrey R., Shibata, Darryl, Hwang, E. Shelley

“…Abstract Introduction. The natural history of preinvasive breast cancer, or ductal carcinoma in situ (DCIS) remains poorly understood. Overcoming this gap…”
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Abstract P1-22-05: Identifying predictors of invasive recurrence based on molecular profiles of DCIS lesions by Bismeijer, Tycho, Ahmed, Ahmed A, Sheinman, Michael, Roman-Escorza, Maria, Shah, Vandna, Marks, Jeffrey R, King, Lorraine M, Megalios, Anargyros, Visser, Lindy L, Hoogstraat, Marlous, Davies, Helen R, Kumar, Tapsi, Collyar, Deborah, Stobart, Hilary, Navin, Nicholas N, Futreal, Andrew, Nik-Zainal, Serena, Hwang, Shelley, Lips, Esther H, Thompson, Alastair, Wessels, Lodewyk FA, Sawyer, Elinor J, Wesseling, Jelle

“…Abstract Introduction Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Patients with DCIS are routinely treated by…”
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Abstract 2683: Ductal carcinoma in situ is a multiclonal disease by Ryser, Marc D., Sorribes, Inmaculada C., Greenwald, Matthew, Hall, Allison, Mallo, Diego, King, Lorraine M., Hardman, Timothy, Simpson, Lunden, Maley, Carlo C., Marks, Jeffrey R., Shibata, Darryl, Hwang, E. Shelley

“…Abstract Introduction. Ductal carcinoma in situ (DCIS) of the breast has a limited propensity to progress to invasive breast cancer. However, due to a lack of…”
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Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts by Strand, Siri H., Rivero-Gutiérrez, Belén, Houlahan, Kathleen E., Seoane, Jose A., King, Lorraine M., Risom, Tyler, Simpson, Lunden A., Vennam, Sujay, Khan, Aziz, Cisneros, Luis, Hardman, Timothy, Harmon, Bryan, Couch, Fergus, Gallagher, Kristalyn, Kilgore, Mark, We, Shi, DeMichele, Angela, King, Tari, McAuliffe, Priscilla F., Nangia, Julie, Lee, Joanna, Tseng, Jennifer, Storniolo, Anna Maria, Thompson, Alastair M., Gupta, Gaorav P., Burns, Robyn, Veis, Deborah J., DeSchryver, Katherine, Zhu, Chunfang, Matusiak, Magdalena, Wang, Jason, Zhu, Shirley X., Tappenden, Jen, Ding, Daisy Yi, Zhang, Dadong, Luo, Jingqin, Jiang, Shu, Varma, Sushama, Anderson, Lauren, Straub, Cody, Srivastava, Sucheta, Curtis, Christina, Tibshirani, Rob, Angelo, Robert Michael, Hall, Allison, Owzar, Kouros, Polyak, Kornelia, Maley, Carlo, Marks, Jeffrey R., Colditz, Graham A., Hwang, E. Shelley, West, Robert B.

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