Search Results - "King, James W. D."

A deep learning method for replicate-based analysis of chromosome conformation contacts using Siamese neural networks by Al-jibury, Ediem, King, James W. D., Guo, Ya, Lenhard, Boris, Fisher, Amanda G., Merkenschlager, Matthias, Rueckert, Daniel

“…The organisation of the genome in nuclear space is an important frontier of biology. Chromosome conformation capture methods such as Hi-C and Micro-C produce…”
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Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes by McAllan, Liam, Baranasic, Damir, Villicaña, Sergio, Brown, Scarlett, Zhang, Weihua, Lehne, Benjamin, Adamo, Marco, Jenkinson, Andrew, Elkalaawy, Mohamed, Mohammadi, Borzoueh, Hashemi, Majid, Fernandes, Nadia, Lambie, Nathalie, Williams, Richard, Christiansen, Colette, Yang, Youwen, Zudina, Liudmila, Lagou, Vasiliki, Tan, Sili, Castillo-Fernandez, Juan, King, James W. D., Soong, Richie, Elliott, Paul, Scott, James, Prokopenko, Inga, Cebola, Inês, Loh, Marie, Lenhard, Boris, Batterham, Rachel L., Bell, Jordana T., Chambers, John C., Kooner, Jaspal S., Scott, William R.

“…DNA methylation variations are prevalent in human obesity but evidence of a causative role in disease pathogenesis is limited. Here, we combine epigenome-wide…”
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Conserved non-coding elements: developmental gene regulation meets genome organization by Polychronopoulos, Dimitris, King, James W D, Nash, Alexander J, Tan, Ge, Lenhard, Boris

“…Comparative genomics has revealed a class of non-protein-coding genomic sequences that display an extraordinary degree of conservation between two or more…”
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Chromatin jets define the properties of cohesin-driven in vivo loop extrusion by Guo, Ya, Al-Jibury, Ediem, Garcia-Millan, Rosalba, Ntagiantas, Konstantinos, King, James W.D., Nash, Alex J., Galjart, Niels, Lenhard, Boris, Rueckert, Daniel, Fisher, Amanda G., Pruessner, Gunnar, Merkenschlager, Matthias

“…Complex genomes show intricate organization in three-dimensional (3D) nuclear space. Current models posit that cohesin extrudes loops to form self-interacting…”
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Three-dimensional chromatin mapping of sensory neurons reveals that promoter-enhancer looping is required for axonal regeneration by Palmisano, Ilaria, Liu, Tong, Gao, Wei, Zhou, Luming, Merkenschlager, Matthias, Mueller, Franziska, Chadwick, Jessica, Toscano Rivalta, Rebecca, Kong, Guiping, King, James W D, Al-Jibury, Ediem, Yan, Yuyang, Carlino, Alessandro, Collison, Bryce, De Vitis, Eleonora, Gongala, Sree, De Virgiliis, Francesco, Wang, Zheng, Di Giovanni, Simone

“…The in vivo three-dimensional genomic architecture of adult mature neurons at homeostasis and after medically relevant perturbations such as axonal injury…”
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Competition shapes the landscape of X-chromosome-linked genetic diversity by Buenaventura, Teresa, Bagci, Hakan, Patrascan, Ilinca, Graham, Joshua J., Hipwell, Kelsey D., Oldenkamp, Roel, King, James W. D., Urtasun, Jesus, Young, George, Mouzo, Daniel, Gomez-Cabrero, David, Rowland, Benjamin D., Panne, Daniel, Fisher, Amanda G., Merkenschlager, Matthias

“…X chromosome inactivation (XCI) generates clonal heterogeneity within XX individuals. Combined with sequence variation between human X chromosomes, XCI gives…”
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Conserved non-coding elements: developmental gene regulation meets genome organization by Polychronopoulos, Dimitris, King, James W. D., Nash, Alexander J., Tan, Ge, Lenhard, Boris

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Conserved helical motifs in the IKZF1 disordered region mediate NuRD interaction and transcriptional repression by Zhang, Tianyi, Wang, Yi-Fang, Montoya, Alex, Patrascan, Ilinca, Nebioglu, Nehir, Pallikonda, Husayn A, Georgieva, Radina, King, James Wd, Kramer, Holger B, Shliaha, Pavel V, Rueda, David S, Merkenschlager, Matthias

“…The transcription factor IKZF1 is essential for B cell development, and recurrently mutated in human B-ALL. IKZF1 has been ascribed both activating and…”
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Complementary and alternative medicine: a survey of its use in pediatric cardiology by Adams, Denise, PhD, Whidden, Ashley, MD, Honkanen, Meeri, MD, Dagenais, Simon, PhD DC, Clifford, Tammy, PhD, Baydala, Lola, MD, MSc, King, W. James, MD, MSc, Vohra, Sunita, MD, MSc

“…Abstract Background The use of complementary and alternative medicine is high among children and youth with chronic illnesses, including patients with cardiac…”
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