Search Results - "King, J. Darwin"
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Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis
Published in Proceedings of the National Academy of Sciences - PNAS (08-02-2011)“…Renal cyst development and expansion in autosomal dominant polycystic kidney disease (ADPKD) involves both fluid secretion and abnormal proliferation of…”
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Noncanonical Control of Vasopressin Receptor Type 2 Signaling by Retromer and Arrestin
Published in The Journal of biological chemistry (27-09-2013)“…The vasopressin type 2 receptor (V2R) is a critical G protein-coupled receptor (GPCR) for vertebrate physiology, including the balance of water and sodium…”
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An Excess-Calcium-Binding-Site Model Predicts Neurotransmitter Release at the Neuromuscular Junction
Published in Biophysical journal (18-06-2013)“…Despite decades of intense experimental studies, we still lack a detailed understanding of synaptic function. Fortunately, using computational approaches, we…”
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AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR
Published in American Journal of Physiology: Cell Physiology (01-07-2009)“…The metabolic sensor AMP-activated protein kinase (AMPK) has emerged as an important link between cellular metabolic status and ion transport activity. We…”
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AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells
Published in American journal of respiratory cell and molecular biology (01-06-2010)“…The metabolic sensor AMP-activated kinase (AMPK) inhibits both the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) Cl(-) channel and epithelial…”
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Role of Binding and Nucleoside Diphosphate Kinase A in the Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator by AMP-activated Protein Kinase
Published in The Journal of biological chemistry (28-09-2012)“…Cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channel mutations cause cystic fibrosis lung disease. A better understanding of CFTR regulatory…”
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CFTR regulation by phosphorylation
Published in Methods in molecular biology (Clifton, N.J.) (2011)“…The cystic fibrosis transmembrane conductance regulator (CFTR) is the gene product mutated in cystic fibrosis, a common lethal genetic disease characterized by…”
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Proportion of N-Type Calcium Current Activated by Action Potential Stimuli
Published in Journal of neurophysiology (01-12-2005)“…Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania Submitted 16 December 2004; accepted in final form 10 August 2005 N-type calcium…”
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Action potential gating of calcium channels and transmitter release
Published 01-01-2007“…The regulation of transmitter release at the neuromuscular junction is tightly regulated by the influx of calcium in the presynaptic nerve terminal…”
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Dissertation -
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Metabolic status changes the interregulation of AMPK and CFTR (893.26)
Published in The FASEB journal (01-04-2014)“…A better understanding of CFTR Cl‐ channel regulation could suggest new therapies for cystic fibrosis (CF). We previously found that the α1 catalytic subunit…”
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Role of Binding and Nucleoside Diphosphate Kinase A (NDPK‐A) in the Regulation of CFTR by AMP‐Activated Protein Kinase (AMPK)
Published in The FASEB journal (01-04-2012)“…Abstract only A better understanding of CFTR Cl − channel regulation could suggest new therapies for cystic fibrosis. AMPK binds to the CFTR C‐terminal tail,…”
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Behavioral Recognition: Computer Algorithms Alerting Law Enforcement to Suspicious Activity
Published in Pittsburgh journal of technology law & policy (10-02-2015)“…Abstract…”
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AMPK Agonists Ameliorate Sodium and Fluid Transport and Inflammation in Cystic Fibrosis Airway Epithelial Cells
Published in American journal of respiratory cell and molecular biology (17-07-2009)“…The metabolic sensor AMP-activated kinase (AMPK) inhibits both the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) Cl − channel and epithelial…”
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Action potential gating of calcium channels and transmitter release
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Dissertation -
15
Clinical evaluation of stannous fluoride as an anticaries mouthrinse
Published in The Journal of the American Dental Association (1939) (01-02-1973)Get more information
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