Search Results - "King, Glenn F"

Spider-Venom Peptides: Structure, Pharmacology, and Potential for Control of Insect Pests by King, Glenn F, Hardy, Margaret C

“…Spider venoms are an incredibly rich source of disulfide-rich insecticidal peptides that have been tuned over millions of years to target a wide range of…”
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Structural basis for the modulation of voltage-gated sodium channels by animal toxins by Shen, Huaizong, Li, Zhangqiang, Jiang, Yan, Pan, Xiaojing, Wu, Jianping, Cristofori-Armstrong, Ben, Smith, Jennifer J, Chin, Yanni K Y, Lei, Jianlin, Zhou, Qiang, King, Glenn F, Yan, Nieng

“…Animal toxins that modulate the activity of voltage-gated sodium (Na ) channels are broadly divided into two categories-pore blockers and gating modifiers. The…”
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Animal toxins — Nature’s evolutionary-refined toolkit for basic research and drug discovery by Herzig, Volker, Cristofori-Armstrong, Ben, Israel, Mathilde R., Nixon, Samantha A., Vetter, Irina, King, Glenn F.

“…[Display omitted] Venomous animals have evolved toxins that interfere with specific components of their victim’s core physiological systems, thereby causing…”
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The venom optimization hypothesis revisited by Morgenstern, David, King, Glenn F.

“…Animal venoms are complex chemical mixtures that typically contain hundreds of proteins and non-proteinaceous compounds, resulting in a potent weapon for prey…”
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Venoms to the rescue by Holford, Mandë, Daly, Marymegan, King, Glenn F, Norton, Raymond S

“…Insights into the evolutionary biology of venoms are leading to therapeutic advances Venomous animals have been admired and feared since prehistoric times, and…”
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The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1a by Herzig, Volker, King, Glenn F

“…The inhibitor cystine knot (ICK) is an unusual three-disulfide architecture in which one of the disulfide bonds bisects a loop formed by the two other…”
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Shining a Light on Venom-Peptide Receptors: Venom Peptides as Targeted Agents for In Vivo Molecular Imaging by Chow, Chun Yuen, King, Glenn F

“…Molecular imaging has revolutionised the field of biomedical research by providing a non-invasive means to visualise and understand biochemical processes…”
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Widespread convergence in toxin resistance by predictable molecular evolution by Ujvari, Beata, Casewell, Nicholas R., Sunagar, Kartik, Arbuckle, Kevin, Wüster, Wolfgang, Lo, Nathan, O’Meally, Denis, Beckmann, Christa, King, Glenn F., Deplazes, Evelyne, Madsen, Thomas

“…The question about whether evolution is unpredictable and stochastic or intermittently constrained along predictable pathways is the subject of a fundamental…”
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Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death by Richards, Kay L., Milligan, Carol J., Richardson, Robert J., Jancovski, Nikola, Grunnet, Morten, Jacobson, Laura H., Undheim, Eivind A. B., Mobli, Mehdi, Chow, Chun Yuen, Herzig, Volker, Csoti, Agota, Panyi, Gyorgy, Reid, Christopher A., King, Glenn F., Petrou, Steven

“…Dravet syndrome is a catastrophic, pharmacoresistant epileptic encephalopathy. Disease onset occurs in the first year of life, followed by developmental delay…”
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Sea Anemone Toxins: A Structural Overview by Madio, Bruno, King, Glenn F, Undheim, Eivind A B

“…Sea anemones produce venoms of exceptional molecular diversity, with at least 17 different molecular scaffolds reported to date. These venom components have…”
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Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models by Yang, Shilong, Xiao, Yao, Di Kang, Liu, Jie, Li, Yuan, Undheim, Eivind A. B., Klint, Julie K., Rong, Mingqiang, Lai, Ren, King, Glenn F.

“…Loss-of-function mutations in the human voltage-gated sodium channel Na V1.7 result in a congenital indifference to pain. Selective inhibitors of Na V1.7 are…”
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Acute inhibition of acid sensing ion channel 1a after spinal cord injury selectively affects excitatory synaptic transmission, but not intrinsic membrane properties, in deep dorsal horn interneurons by Foster, Victoria S, Saez, Natalie, King, Glenn F, Rank, Michelle M

“…Following a spinal cord injury (SCI), secondary damage mechanisms are triggered that cause inflammation and cell death. A key component of this secondary…”
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The assassin bug Pristhesancus plagipennis produces two distinct venoms in separate gland lumens by Walker, Andrew A., Mayhew, Mark L., Jin, Jiayi, Herzig, Volker, Undheim, Eivind A. B., Sombke, Andy, Fry, Bryan G., Meritt, David J., King, Glenn F.

“…The assassin bug venom system plays diverse roles in prey capture, defence and extra-oral digestion, but it is poorly characterised, partly due to its…”
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Entomo-venomics: The evolution, biology and biochemistry of insect venoms by Walker, Andrew A., Robinson, Samuel D., Yeates, David K., Jin, Jiayi, Baumann, Kate, Dobson, James, Fry, Bryan G., King, Glenn F.

“…The insects are a hyperdiverse class containing more species than all other animal groups combined—and many employ venom to capture prey, deter predators and…”
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Deadly Proteomes: A Practical Guide to Proteotranscriptomics of Animal Venoms by Walker, Andrew A., Robinson, Samuel D., Hamilton, Brett F., Undheim, Eivind A. B., King, Glenn F.

“…Animal venoms are renowned for their toxicity, biochemical complexity, and as a source of compounds with potential applications in medicine, agriculture, and…”
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The insecticidal potential of venom peptides by Smith, Jennifer J., Herzig, Volker, King, Glenn F., Alewood, Paul F.

“…Pest insect species are a burden to humans as they destroy crops and serve as vectors for a wide range of diseases including malaria and dengue. Chemical…”
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Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels by Lau, Carus H. Y., King, Glenn F., Mobli, Mehdi

“…Voltage-sensor domains (VSDs) are modular transmembrane domains of voltage-gated ion channels that respond to changes in membrane potential by undergoing…”
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Macromolecular NMR spectroscopy for the non-spectroscopist by Kwan, Ann H, Mobli, Mehdi, Gooley, Paul R, King, Glenn F, Mackay, Joel P

“…NMR spectroscopy is a powerful tool for studying the structure, function and dynamics of biological macromolecules. However, non-spectroscopists often find NMR…”
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Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy by Simons, Cas, Rash, Lachlan D, Crawford, Joanna, Ma, Linlin, Cristofori-Armstrong, Ben, Miller, David, Ru, Kelin, Baillie, Gregory J, Alanay, Yasemin, Jacquinet, Adeline, Debray, François-Guillaume, Verloes, Alain, Shen, Joseph, Yesil, Gözde, Guler, Serhat, Yuksel, Adnan, Cleary, John G, Grimmond, Sean M, McGaughran, Julie, King, Glenn F, Gabbett, Michael T, Taft, Ryan J

“…Cas Simons, Ryan Taft and colleagues report the identification of KCNH1 mutations in six individuals with Temple-Baraitser syndrome (TBS). Electrophysiological…”
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Phylogeny, envenomation syndrome, and membrane permeabilising venom produced by Australia’s electric caterpillar Comana monomorpha by Goudarzi, Mohaddeseh H., Robinson, Samuel D., Cardoso, Fernanda C., Mitchell, Michela L., Cook, Lyn G., King, Glenn F., Walker, Andrew A.

“…Zygaenoidea is a superfamily of lepidopterans containing many venomous species, including the Limacodidae (nettle caterpillars) and Megalopygidae (asp…”
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