Search Results - "King, Bryan W"

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity by Mandal, Pratyusha, Berger, Scott B., Pillay, Sirika, Moriwaki, Kenta, Huang, Chunzi, Guo, Hongyan, Lich, John D., Finger, Joshua, Kasparcova, Viera, Votta, Bart, Ouellette, Michael, King, Bryan W., Wisnoski, David, Lakdawala, Ami S., DeMartino, Michael P., Casillas, Linda N., Haile, Pamela A., Sehon, Clark A., Marquis, Robert W., Upton, Jason, Daley-Bauer, Lisa P., Roback, Linda, Ramia, Nancy, Dovey, Cole M., Carette, Jan E., Chan, Francis Ka-Ming, Bertin, John, Gough, Peter J., Mocarski, Edward S., Kaiser, William J.

“…Receptor-interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease…”
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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases by Harris, Philip A, Berger, Scott B, Jeong, Jae U, Nagilla, Rakesh, Bandyopadhyay, Deepak, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Eidam, Patrick M, Finger, Joshua N, Hoffman, Sandra J, Kang, James, Kasparcova, Viera, King, Bryan W, Lehr, Ruth, Lan, Yunfeng, Leister, Lara K, Lich, John D, MacDonald, Thomas T, Miller, Nathan A, Ouellette, Michael T, Pao, Christina S, Rahman, Attiq, Reilly, Michael A, Rendina, Alan R, Rivera, Elizabeth J, Schaeffer, Michelle C, Sehon, Clark A, Singhaus, Robert R, Sun, Helen H, Swift, Barbara A, Totoritis, Rachel D, Vossenkämper, Anna, Ward, Paris, Wisnoski, David D, Zhang, Daohua, Marquis, Robert W, Gough, Peter J, Bertin, John

“…RIP1 regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including immune-mediated…”
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The Identification and Pharmacological Characterization of 6‑(tert-Butylsulfonyl)‑N‑(5-fluoro‑1H‑indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase by Haile, Pamela A, Votta, Bartholomew J, Marquis, Robert W, Bury, Michael J, Mehlmann, John F, Singhaus, Robert, Charnley, Adam K, Lakdawala, Ami S, Convery, Máire A, Lipshutz, David B, Desai, Biva M, Swift, Barbara, Capriotti, Carol A, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Rivera, Elizabeth J, Sun, Helen H, Nagilla, Rakesh, Beal, Allison M, Finger, Joshua N, Cook, Michael N, King, Bryan W, Ouellette, Michael T, Totoritis, Rachel D, Pierdomenico, Maria, Negroni, Anna, Stronati, Laura, Cucchiara, Salvatore, Ziółkowski, Bartłomiej, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Casillas, Linda N

“…RIP2 kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1…”
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Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening by Machutta, Carl A., Kollmann, Christopher S., Lind, Kenneth E., Bai, Xiaopeng, Chan, Pan F., Huang, Jianzhong, Ballell, Lluis, Belyanskaya, Svetlana, Besra, Gurdyal S., Barros-Aguirre, David, Bates, Robert H., Centrella, Paolo A., Chang, Sandy S., Chai, Jing, Choudhry, Anthony E., Coffin, Aaron, Davie, Christopher P., Deng, Hongfeng, Deng, Jianghe, Ding, Yun, Dodson, Jason W., Fosbenner, David T., Gao, Enoch N., Graham, Taylor L., Graybill, Todd L., Ingraham, Karen, Johnson, Walter P., King, Bryan W., Kwiatkowski, Christopher R., Lelièvre, Joël, Li, Yue, Liu, Xiaorong, Lu, Quinn, Lehr, Ruth, Mendoza-Losana, Alfonso, Martin, John, McCloskey, Lynn, McCormick, Patti, O’Keefe, Heather P., O’Keeffe, Thomas, Pao, Christina, Phelps, Christopher B., Qi, Hongwei, Rafferty, Keith, Scavello, Genaro S., Steiginga, Matt S., Sundersingh, Flora S., Sweitzer, Sharon M., Szewczuk, Lawrence M., Taylor, Amy, Toh, May Fern, Wang, Juan, Wang, Minghui, Wilkins, Devan J., Xia, Bing, Yao, Gang, Zhang, Jean, Zhou, Jingye, Donahue, Christine P., Messer, Jeffrey A., Holmes, David, Arico-Muendel, Christopher C., Pope, Andrew J., Gross, Jeffrey W., Evindar, Ghotas

“…The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have…”
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Asymmetric Aldol Additions:  Use of Titanium Tetrachloride and (−)-Sparteine for the Soft Enolization of N-Acyl Oxazolidinones, Oxazolidinethiones, and Thiazolidinethiones by Crimmins, Michael T, King, Bryan W, Tabet, Elie A, Chaudhary, Kleem

“…Asymmetric aldol additions using chlorotitanium enolates of N-acyloxazolidinone, oxazolidinethione, and thiazolidinethione propionates proceed with high…”
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DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors by Harris, Philip A, King, Bryan W, Bandyopadhyay, Deepak, Berger, Scott B, Campobasso, Nino, Capriotti, Carol A, Cox, Julie A, Dare, Lauren, Dong, Xiaoyang, Finger, Joshua N, Grady, LaShadric C, Hoffman, Sandra J, Jeong, Jae U, Kang, James, Kasparcova, Viera, Lakdawala, Ami S, Lehr, Ruth, McNulty, Dean E, Nagilla, Rakesh, Ouellette, Michael T, Pao, Christina S, Rendina, Alan R, Schaeffer, Michelle C, Summerfield, Jennifer D, Swift, Barbara A, Totoritis, Rachel D, Ward, Paris, Zhang, Aming, Zhang, Daohua, Marquis, Robert W, Bertin, John, Gough, Peter J

“…The recent discovery of the role of receptor interacting protein 1 (RIP1) kinase in tumor necrosis factor (TNF)-mediated inflammation has led to its emergence…”
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An Efficient Asymmetric Approach to Carbocyclic Nucleosides:  Asymmetric Synthesis of 1592U89, a Potent Inhibitor of HIV Reverse Transcriptase by Crimmins, Michael T, King, Bryan W

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Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors by Horton, John R., Pathuri, Sarath, Wong, Kristen, Ren, Ren, Rueda, Lourdes, Fosbenner, David T., Heerding, Dirk A., McCabe, Michael T., Pappalardi, Melissa B., Zhang, Xing, King, Bryan W., Cheng, Xiaodong

“…DNMT1 maintains the parental DNA methylation pattern on newly replicated hemimethylated DNA. The failure of this maintenance process causes aberrant DNA…”
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Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2‑((4-(Benzo[d]­thiazol-5-ylamino)-6‑(tert-butylsulfonyl)­quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases by Haile, Pamela A, Casillas, Linda N, Votta, Bartholomew J, Wang, Gren Z, Charnley, Adam K, Dong, Xiaoyang, Bury, Michael J, Romano, Joseph J, Mehlmann, John F, King, Bryan W, Erhard, Karl F, Hanning, Charles R, Lipshutz, David B, Desai, Biva M, Capriotti, Carol A, Schaeffer, Michelle C, Berger, Scott B, Mahajan, Mukesh K, Reilly, Michael A, Nagilla, Rakesh, Rivera, Elizabeth J, Sun, Helen H, Kenna, John K, Beal, Allison M, Ouellette, Michael T, Kelly, Mike, Stemp, Gillian, Convery, Máire A, Vossenkämper, Anna, MacDonald, Thomas T, Gough, Peter J, Bertin, John, Marquis, Robert W

“…RIP2 kinase has been identified as a key signal transduction partner in the NOD2 pathway contributing to a variety of human pathologies, including…”
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Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement by Barton, Linda S., Callahan, James F., Cantizani, Juan, Concha, Nestor O., Cotillo Torrejon, Ignacio, Goodwin, Nicole C., Joshi-Pangu, Amruta, Kiesow, Terry J., McAtee, Jeff J., Mellinger, Mark, Nixon, Christopher J., Padrón-Barthe, Laura, Patterson, Jaclyn R., Pearson, Neil D., Pouliot, Jeffrey J., Rendina, Alan R., Buitrago Santanilla, Alexander, Schneck, Jessica L., Sanz, Olalla, Thalji, Reema K., Ward, Paris, Williams, Shawn P., King, Bryan W.

“…[Display omitted] •P1 analogues with aldehyde warhead prepared and tested against 3CLpro in SARS-CoV-2.•Discovery of 2-THF as P1 residue with potent inhibition…”
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DNA-Encoded Library Hit Confirmation: Bridging the Gap Between On-DNA and Off-DNA Chemistry by Xia, Bing, Franklin, G. Joseph, Lu, Xiaojie, Bedard, Katie L, Grady, LaShadric C, Summerfield, Jennifer D, Shi, Eric X, King, Bryan W, Lind, Kenneth E, Chiu, Cynthia, Watts, Eleanor, Bodmer, Vera, Bai, Xiaopeng, Marcaurelle, Lisa A

“…DNA-encoded library (DEL) technology is a powerful platform for hit identification in academia and the pharmaceutical industry. When conducting off-DNA…”
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Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity by Charnley, Adam K., Convery, Máire A., Lakdawala Shah, Ami, Jones, Emma, Hardwicke, Philip, Bridges, Angela, Ouellette, Michael, Totoritis, Rachel, Schwartz, Benjamin, King, Bryan W., Wisnoski, David D., Kang, James, Eidam, Patrick M., Votta, Bartholomew J., Gough, Peter J., Marquis, Robert W., Bertin, John, Casillas, Linda

“…[Display omitted] Receptor interacting protein 2 (RIP2) is an intracellular kinase and key signaling partner for the pattern recognition receptors NOD1 and…”
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Regioselectivity in the Palladium-Catalyzed Addition of Carbon Nucleophiles to Carbocyclic Derivatives by Hoke, Molly E, Brescia, Marc-Raleigh, Bogaczyk, Suzanne, DeShong, Philip, King, Bryan W, Crimmins, Michael T

“…The regioselectivity of Pd-catalyzed malonate additions and arylations to cycloalkenyl esters can be predicted by completing a stereochemical analysis of the…”
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Synthesis of the C1−C13 Fragment of Leucascandrolide A by Crimmins, Michael T, Carroll, Charlotte A, King, Bryan W

“…The synthesis of the C1−C13 fragment 3 of leucascandrolide A has been completed utilizing a stereoselective and regioselective reductive cleavage of a highly…”
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Correction: Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening by Machutta, Carl A., Kollmann, Christopher S., Lind, Kenneth E., Bai, Xiaopeng, Chan, Pan F., Huang, Jianzhong, Ballell, Lluis, Belyanskaya, Svetlana, Besra, Gurdyal S., Barros-Aguirre, David, Bates, Robert H., Centrella, Paolo A., Chang, Sandy S., Chai, Jing, Choudhry, Anthony E., Coffin, Aaron, Davie, Christopher P., Deng, Hongfeng, Deng, Jianghe, Ding, Yun, Dodson, Jason W., Fosbenner, David T., Gao, Enoch N., Graham, Taylor L., Graybill, Todd L., Ingraham, Karen, Johnson, Walter P., King, Bryan W., Kwiatkowski, Christopher R., Lelièvre, Joël, Li, Yue, Liu, Xiaorong, Lu, Quinn, Lehr, Ruth, Mendoza-Losana, Alfonso, Martin, John, McCloskey, Lynn, McCormick, Patti, O’Keefe, Heather P., O’Keeffe, Thomas, Pao, Christina, Phelps, Christopher B., Qi, Hongwei, Rafferty, Keith, Scavello, Genaro S., Steiginga, Matt S., Sundersingh, Flora S., Sweitzer, Sharon M., Szewczuk, Lawrence M., Taylor, Amy, Fern Toh, May, Wang, Juan, Wang, Minghui, Wilkins, Devan J., Xia, Bing, Yao, Gang, Zhang, Jean, Zhou, Jingye, Donahue, Christine P., Messer, Jeffrey A., Holmes, David, Arico-Muendel, Christopher C., Pope, Andrew J., Gross, Jeffrey W., Evindar, Ghotas

“…Nature Communications 8: Article number: 16081 (2017); Published: 17 July 2017, Updated: 13 July 2018 The original version of this Article omitted the…”
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Asymmetric Aldol Additions with Titanium Enolates of Acyloxazolidinethiones:  Dependence of Selectivity on Amine Base and Lewis Acid Stoichiometry by Crimmins, Michael T, King, Bryan W, Tabet, Elie A

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An Efficient, General Asymmetric Synthesis of Carbocyclic Nucleosides:  Application of an Asymmetric Aldol/Ring-Closing Metathesis Strategy by Crimmins, Michael T, King, Bryan W, Zuercher, William J, Choy, Allison L

“…A general and efficient synthesis of carbocyclic and hexenopyranosyl nucleosides has been developed. The strategy combines three key transformations:  an…”
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Asymmetric Total Synthesis of Callystatin A:  Asymmetric Aldol Additions with Titanium Enolates of Acyloxazolidinethiones by Crimmins, Michael T, King, Bryan W

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Understanding the Origins of Time-Dependent Inhibition by Polypeptide Deformylase Inhibitors by Totoritis, Rachel, Duraiswami, Chaya, Taylor, Amy N, Kerrigan, John J, Campobasso, Nino, Smith, Katherine J, Ward, Paris, King, Bryan W, Murrayz-Thompson, Monique, Jones, Amber D, Van Aller, Glenn S, Aubart, Kelly M, Zalacain, Magdalena, Thrall, Sara H, Meek, Thomas D, Schwartz, Benjamin

“…The continual bacterial adaptation to antibiotics creates an ongoing medical need for the development of novel therapeutics. Polypeptide deformylase (PDF) is a…”
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Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening by Machutta, Carl A, Kollmann, Christopher S, Lind, Kenneth E, Bai, Xiaopeng, Chan, Pan F, Huang, Jianzhong, Ballell, Lluis, Belyanskaya, Svetlana, Besra, Gurdyal S, Barros-Aguirre, David, Bates, Robert H, Centrella, Paolo A, Chang, Sandy S, Chai, Jing, Choudhry, Anthony E, Coffin, Aaron, Davie, Christopher P, Deng, Hongfeng, Deng, Jianghe, Ding, Yun, Dodson, Jason W, Fosbenner, David T, Gao, Enoch N, Graham, Taylor L, Graybill, Todd L, Ingraham, Karen, Johnson, Walter P, King, Bryan W, Kwiatkowski, Christopher R, Lelièvre, Joël, Li, Yue, Liu, Xiaorong, Lu, Quinn, Lehr, Ruth, Mendoza-Losana, Alfonso, Martin, John, McCloskey, Lynn, McCormick, Patti, O'Keefe, Heather P, O'Keeffe, Thomas, Pao, Christina, Phelps, Christopher B, Qi, Hongwei, Rafferty, Keith, Scavello, Genaro S, Steiginga, Matt S, Sundersingh, Flora S, Sweitzer, Sharon M, Szewczuk, Lawrence M, Taylor, Amy, Fern Toh, May, Wang, Juan, Wang, Minghui, Wilkins, Devan J, Xia, Bing, Yao, Gang, Zhang, Jean, Zhou, Jingye, Donahue, Christine P, Messer, Jeffrey A, Holmes, David, Arico-Muendel, Christopher C, Pope, Andrew J, Gross, Jeffrey W, Evindar, Ghotas

“…This corrects the article DOI: 10.1038/ncomms16081…”
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