Search Results - "King, Anna E"

Excitotoxicity in ALS: Overstimulation, or overreaction? by King, Anna E., Woodhouse, Adele, Kirkcaldie, Matthew T.K., Vickers, James C.

“…Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results in motor dysfunction and death, generally from respiratory…”
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C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking by Farg, Manal A, Sundaramoorthy, Vinod, Sultana, Jessica M, Yang, Shu, Atkinson, Rachel A K, Levina, Vita, Halloran, Mark A, Gleeson, Paul A, Blair, Ian P, Soo, Kai Y, King, Anna E, Atkin, Julie D

“…Intronic expansion of a hexanucleotide GGGGCC repeat in the chromosome 9 open reading frame 72 (C9ORF72) gene is the major cause of familial amyotrophic…”
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Seeing Neurodegeneration in a New Light Using Genetically Encoded Fluorescent Biosensors and iPSCs by Stellon, David, Talbot, Jana, Hewitt, Alex W, King, Anna E, Cook, Anthony L

“…Neurodegenerative diseases present a progressive loss of neuronal structure and function, leading to cell death and irrecoverable brain atrophy. Most have…”
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AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo by Hung, Sandy S C, Chrysostomou, Vicki, Li, Fan, Lim, Jeremiah K H, Wang, Jiang-Hui, Powell, Joseph E, Tu, Leilei, Daniszewski, Maciej, Lo, Camden, Wong, Raymond C, Crowston, Jonathan G, Pébay, Alice, King, Anna E, Bui, Bang V, Liu, Guei-Sheung, Hewitt, Alex W

“…Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein (Cas) has recently been adapted to enable efficient editing of the…”
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Defining the earliest pathological changes of Alzheimer's disease by Vickers, James C, Mitew, Stan, Woodhouse, Adele, Fernandez-Martos, Carmen M, Kirkcaldie, Mathew T, Canty, Alison J, McCormack, Graeme H, King, Anna E

“…The prospects for effectively treating well-established dementia, such as Alzheimer's disease (AD), are slim, due to the destruction of key brain pathways that…”
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An online, public health framework supporting behaviour change to reduce dementia risk: interim results from the ISLAND study linking ageing and neurodegenerative disease by Bartlett, Larissa, Bindoff, Aidan, Doherty, Kathleen, Kim, Sarang, Eccleston, Claire, Kitsos, Alex, Roccati, Eddy, Alty, Jane, King, Anna E, Vickers, James C

“…Abstract Background Unmanaged cardiometabolic health, low physical and cognitive activity, poor diet, obesity, smoking and excessive alcohol consumption are…”
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Sarm1 knockout modifies biomarkers of neurodegeneration and spinal cord circuitry but not disease progression in the mSOD1G93A mouse model of ALS by Collins, Jessica M., Atkinson, Rachel A.K., Matthews, Lyzette M., Murray, Isabella C., Perry, Sharn E., King, Anna E.

“…The mechanisms underlying the loss of motor neuron axon integrity in amyotrophic lateral sclerosis (ALS) are unclear. SARM1 has been identified as a genetic…”
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Microglia directly associate with pericytes in the central nervous system by Morris, Gary P., Foster, Catherine G., Courtney, Jo‐Maree, Collins, Jessica M., Cashion, Jake M., Brown, Lachlan S., Howells, David W., DeLuca, Gabriele C., Canty, Alison J., King, Anna E., Ziebell, Jenna M., Sutherland, Brad A.

“…Cerebral blood flow (CBF) is important for the maintenance of brain function and its dysregulation has been implicated in Alzheimer's disease (AD). Microglia…”
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The Influence of Genetic Factors and Cognitive Reserve on Structural and Functional Resting-State Brain Networks in Aging and Alzheimer's Disease by Pietzuch, Manuela, King, Anna E, Ward, David D, Vickers, James C

“…Magnetic resonance imaging (MRI) offers significant insight into the complex organization of neural networks within the human brain. Using resting-state…”
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Mild and repetitive very mild axonal stretch injury triggers cystoskeletal mislocalization and growth cone collapse by Yap, Yiing C, King, Anna E, Guijt, Rosanne M, Jiang, Tongcui, Blizzard, Catherine A, Breadmore, Michael C, Dickson, Tracey C

“…Diffuse axonal injury is a hallmark pathological consequence of non-penetrative traumatic brain injury (TBI) and yet the axonal responses to stretch injury are…”
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Does serum neurofilament light help predict accelerated cognitive ageing in unimpaired older adults? by Collins, Jessica M., Bindoff, Aidan D., Roccati, Eddy, Alty, Jane E., Vickers, James C., King, Anna E.

“…Introduction Neurofilament light (NfL) is a blood biomarker of neurodegeneration. While serum NfL levels have been demonstrated to increase with normal ageing,…”
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The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease by Collins, Jessica M., King, Anna E., Woodhouse, Adele, Kirkcaldie, Matthew T.K., Vickers, James C.

“…Traumatic brain injury is a risk factor for Alzheimer's disease (AD), however the effect of such neural damage on the onset and progression of beta-amyloid…”
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The HDAC6 Inhibitor Trichostatin A Acetylates Microtubules and Protects Axons From Excitotoxin-Induced Degeneration in a Compartmented Culture Model by Hanson, Kelsey, Tian, Nan, Vickers, James C, King, Anna E

“…Axon degeneration has been implicated as a pathological process in several neurodegenerative diseases and acquired forms of neural injury. We have previously…”
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Development of a smartphone screening test for preclinical Alzheimer's disease and validation across the dementia continuum by Alty, Jane, Goldberg, Lynette R, Roccati, Eddy, Lawler, Katherine, Bai, Quan, Huang, Guan, Bindoff, Aidan D, Li, Renjie, Wang, Xinyi, St George, Rebecca J, Rudd, Kaylee, Bartlett, Larissa, Collins, Jessica M, Aiyede, Mimieveshiofuo, Fernando, Nadeeshani, Bhagwat, Anju, Giffard, Julia, Salmon, Katharine, McDonald, Scott, King, Anna E, Vickers, James C

“…Dementia prevalence is predicted to triple to 152 million globally by 2050. Alzheimer's disease (AD) constitutes 70% of cases. There is an urgent need to…”
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Association Between Components of Cognitive Reserve and Serum BDNF in Healthy Older Adults by Collins, Jessica M., Hill, Edward, Bindoff, Aidan, King, Anna E., Alty, Jane, Summers, Mathew J., Vickers, James C.

“…Background : The brain-derived neurotrophic factor (BDNF) protein has been shown to have a prominent role in neuron survival, growth, and function in…”
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Iron is increased in the brains of ageing mice lacking the neurofilament light gene by Vickers, James C, King, Anna E, McCormack, Graeme H, Bindoff, Aidan D, Adlard, Paul A

“…There has been strong interest in the role of metals in neurodegeneration, and how ageing may predispose the brain to related diseases such as Alzheimer's…”
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Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model by Stuart, Kimberley E., King, Anna E., Fernandez-Martos, Carmen M., Summers, Mathew J., Vickers, James C.

“…Cognitive stimulation has been proposed as a non-pharmacological intervention to be used in primary, secondary and tertiary prevention approaches for…”
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The TAS Test project: a prospective longitudinal validation of new online motor-cognitive tests to detect preclinical Alzheimer’s disease and estimate 5-year risks of cognitive decline and dementia by Alty, Jane, Bai, Quan, Li, Renjie, Lawler, Katherine, St George, Rebecca J, Hill, Edward, Bindoff, Aidan, Garg, Saurabh, Wang, Xinyi, Huang, Guan, Zhang, Kaining, Rudd, Kaylee D, Bartlett, Larissa, Goldberg, Lynette R, Collins, Jessica M, Hinder, Mark R, Naismith, Sharon L, Hogg, David C, King, Anna E, Vickers, James C

“…Abstract Background The worldwide prevalence of dementia is rapidly rising. Alzheimer’s disease (AD), accounts for 70% of cases and has a 10–20-year…”
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Lysosomal alterations and decreased electrophysiological activity in CLN3 disease patient-derived cortical neurons by Chear, Sueanne, Perry, Sharn, Wilson, Richard, Bindoff, Aidan, Talbot, Jana, Ware, Tyson L, Grubman, Alexandra, Vickers, James C, Pébay, Alice, Ruddle, Jonathan B, King, Anna E, Hewitt, Alex W, Cook, Anthony L

“…CLN3 disease is a lysosomal storage disorder associated with fatal neurodegeneration that is caused by mutations in CLN3, with most affected individuals…”
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Connectivity of Pathology: The Olfactory System as a Model for Network-Driven Mechanisms of Alzheimer's Disease Pathogenesis by Franks, Katherine H, Chuah, Meng Inn, King, Anna E, Vickers, James C

“…The pathogenesis of Alzheimer's disease (AD) has been postulated to preferentially impact specific neural networks in the brain. The olfactory system is a…”
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