Search Results - "King, Alvin R"

A Second Generation of Carbamate-Based Fatty Acid Amide Hydrolase Inhibitors with Improved Activity in vivo by Clapper, Jason R., Vacondio, Federica, King, Alvin R., Duranti, Andrea, Tontini, Andrea, Silva, Claudia, Sanchini, Silvano, Tarzia, Giorgio, Mor, Marco, Piomelli, Daniele

“…The fatty acid ethanolamides are a class of signaling lipids that include agonists at cannabinoid and α type peroxisome proliferator‐activated receptors…”
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Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes by Mattis, Virginia B, Svendsen, Soshana P, Ebert, Allison, Svendsen, Clive N, King, Alvin R, Casale, Malcolm, Winokur, Sara T, Batugedara, Gayani, Vawter, Marquis, Donovan, Peter J, Lock, Leslie F, Thompson, Leslie M, Zhu, Yu, Fossale, Elisa, Singh Atwal, Ranjit, Gillis, Tammy, Mysore, Jayalakshmi, Li, Jian-hong, Seong, IhnSik, Shen, Yiping, Chen, Xiaoli, Wheeler, Vanessa C, MacDonald, Marcy E, Gusella, James F, Akimov, Sergey, Arbez, Nicolas, Juopperi, Tarja, Ratovitski, Tamara, Chiang, Jason H, Kim, Woon Roung, Chighladze, Eka, Watkin, Erin, Zhong, Chun, Makri, Georgia, Cole, Robert N, Margolis, Russell L, Song, Hongjun, Ming, Guoli, Ross, Christopher A, Kaye, Julia A, Daub, Aaron, Sharma, Punita, Mason, Amanda R, Finkbeiner, Steven, Yu, Junying, Thomson, James A, Rushton, David, Brazier, Stephen P, Battersby, Alysia A, Redfern, Amanda, Tseng, Hsui-Er, Harrison, Alexander W, Kemp, Paul J, Allen, Nicholas D, Onorati, Marco, Castiglioni, Valentina, Cattaneo, Elena, Arjomand, Jamshid

“…Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded stretch of CAG trinucleotide repeats that results in neuronal…”
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Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites by Kedaigle, Amanda J, Fraenkel, Ernest, Atwal, Ranjit S, Wu, Min, Gusella, James F, MacDonald, Marcy E, Kaye, Julia A, Finkbeiner, Steven, Mattis, Virginia B, Tom, Colton M, Svendsen, Clive, King, Alvin R, Chen, Yumay, Stocksdale, Jennifer T, Lim, Ryan G, Casale, Malcolm, Wang, Ping H, Thompson, Leslie M, Akimov, Sergey S, Ratovitski, Tamara, Arbez, Nicolas, Ross, Christopher A

“…Altered cellular metabolism is believed to be an important contributor to pathogenesis of the neurodegenerative disorder Huntington's disease (HD). Research…”
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Fatty Acid Amide Hydrolase Inhibition Heightens Anandamide Signaling Without Producing Reinforcing Effects in Primates by Justinova, Zuzana, Mangieri, Regina A, Bortolato, Marco, Chefer, Svetlana I, Mukhin, Alexey G, Clapper, Jason R, King, Alvin R, Redhi, Godfrey H, Yasar, Sevil, Piomelli, Daniele, Goldberg, Steven R

“…Background CB1 cannabinoid receptors in the brain are known to participate in the regulation of reward-based behaviors. However, the contribution of each of…”
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Synthesis and Quantitative Structure−Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates by Mor, Marco, Lodola, Alessio, Rivara, Silvia, Vacondio, Federica, Duranti, Andrea, Tontini, Andrea, Sanchini, Silvano, Piersanti, Giovanni, Clapper, Jason R, King, Alvin R, Tarzia, Giorgio, Piomelli, Daniele

“…Alkylcarbamic acid biphenyl-3-yl esters are a class of fatty acid amide hydrolase (FAAH) inhibitors that comprises cyclohexylcarbamic acid…”
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Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats by Thorsell, Annika, Repunte-Canonigo, Vez, O'Dell, Laura E., Chen, Scott A., King, Alvin R., Lekic, Dusan, Koob, George F., Paolo Sanna, Pietro

“…Acute administration of neuropeptide Y (NPY) modulates alcohol intake in genetic and chemical models of high intake, while leaving intake unaffected during…”
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Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1 by Cammalleri, Maurizio, Lütjens, Robert, Berton, Fulvia, King, Alvin R, Simpson, Cindy, Francesconi, Walter, Sanna, Pietro Paolo

“…Mammalian target of rapamycin (mTOR) is a key regulator of translational capacity. The mTOR inhibitor rapamycin can prevent forms of protein…”
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URB602 Inhibits Monoacylglycerol Lipase and Selectively Blocks 2-Arachidonoylglycerol Degradation in Intact Brain Slices by King, Alvin R., Duranti, Andrea, Tontini, Andrea, Rivara, Silvia, Rosengarth, Anja, Clapper, Jason R., Astarita, Giuseppe, Geaga, Jennifer A., Luecke, Hartmut, Mor, Marco, Tarzia, Giorgio, Piomelli, Daniele

“…The N-aryl carbamate URB602 (biphenyl-3-ylcarbamic acid cyclohexyl ester) is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the…”
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Synthesis and Quantitative Structure−Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates by Mor, Marco, Lodola, Alessio, Rivara, Silvia, Vacondio, Federica, Duranti, Andrea, Tontini, Andrea, Sanchini, Silvano, Piersanti, Giovanni, Clapper, Jason R, King, Alvin R, Tarzia, Giorgio, Piomelli, Daniele

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Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors by King, Alvin R., Dotsey, Emmanuel Y., Lodola, Alessio, Jung, Kwang Mook, Ghomian, Azar, Qiu, Yan, Fu, Jin, Mor, Marco, Piomelli, Daniele

“…Monoacylglycerol lipase (MGL) is a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl- sn-glycerol (2-AG). Previous…”
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Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice by Lim, Ryan G, Salazar, Lisa L, Wilton, Daniel K, King, Alvin R, Stocksdale, Jennifer T, Sharifabad, Delaram, Lau, Alice L, Stevens, Beth, Reidling, Jack C, Winokur, Sara T, Casale, Malcolm S, Thompson, Leslie M, Pardo, Mónica, Díaz-Barriga, A Gerardo García, Straccia, Marco, Sanders, Phil, Alberch, Jordi, Canals, Josep M, Kaye, Julia A, Dunlap, Mariah, Jo, Lisa, May, Hanna, Mount, Elliot, Anderson-Bergman, Cliff, Haston, Kelly, Finkbeiner, Steven, Kedaigle, Amanda J, Gipson, Theresa A, Yildirim, Ferah, Ng, Christopher W, Milani, Pamela, Housman, David E, Fraenkel, Ernest, Allen, Nicholas D, Kemp, Paul J, Atwal, Ranjit Singh, Biagioli, Marta, Gusella, James F, MacDonald, Marcy E, Akimov, Sergey S, Arbez, Nicolas, Stewart, Jacqueline, Ross, Christopher A, Mattis, Virginia B, Tom, Colton M, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Svendsen, Clive N

“…The Huntington's disease (HD) induced pluripotent stem cell (iPSC) consortium describe the combined use of differentiated patient-derived iPSCs and systems…”
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Gene profiling of laser-microdissected brain regions and sub-regions by Sanna, Pietro Paolo, King, Alvin R., van der Stap, Lena D., Repunte-Canonigo, Vez

“…The application of transcriptomics and proteomics approaches to accurately dissected anatomically-defined brain regions and sub-regions remains a central focus…”
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Synthesis and QSAR of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates by Mor, Marco, Lodola, Alessio, Rivara, Silvia, Vacondio, Federica, Duranti, Andrea, Tontini, Andrea, Sanchini, Silvano, Piersanti, Giovanni, Clapper, Jason R., King, Alvin R., Tarzia, Giorgio, Piomelli, Daniele

“…Alkylcarbamic acid biphenyl-3-yl esters are a class of fatty acid amide hydrolase (FAAH) inhibitors that comprises cyclohexylcarbamic acid…”
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Cover Picture: Structure-Property Relationships of a Class of Carbamate-Based Fatty Acid Amide Hydrolase (FAAH) Inhibitors: Chemical and Biological Stability / A Second Generation of Carbamate-Based Fatty Acid Amide Hydrolase Inhibitors with Improved Activity in vivo (ChemMedChem 9/2009) by Vacondio, Federica, Silva, Claudia, Lodola, Alessio, Fioni, Alessandro, Rivara, Silvia, Duranti, Andrea, Tontini, Andrea, Sanchini, Silvano, Clapper, Jason R., Piomelli, Daniele, Mor, Marco, Tarzia, Giorgio, King, Alvin R.

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Time-restricted role for dendritic activation of the mTOR-p70 S6K pathway in the induction of late-phase long-term potentiation in the CA1 by Cammalleri, Maurizio, Lütjens, Robert, Berton, Fulvia, King, Alvin R., Simpson, Cindy, Francesconi, Walter, Sanna, Pietro Paolo

“…Mammalian target of rapamycin (mTOR) is a key regulator of translational capacity. The mTOR inhibitor rapamycin can prevent forms of protein…”
Get full text

Time-Restricted Role for Dendritic Activation of the mTOR-p70S6KPathway in the Induction of Late-Phase Long-Term Potentiation in the CA1 by Cammalleri, Maurizio, Lütjens, Robert, Berton, Fulvia, King, Alvin R., Simpson, Cindy, Francesconi, Walter, Sanna, Pietro Paolo

“…Mammalian target of rapamycin (mTOR) is a key regulator of translational capacity. The mTOR inhibitor rapamycin can prevent forms of protein…”
Get full text

Protocol: Gene profiling of laser-microdissected brain regions and sub-regions by Sanna, Pietro Paolo, King, Alvin R, van der Stap, Lena D, Repunte-Canonigo, Vez

“…The application of transcriptomics and proteomics approaches to accurately dissected anatomically-defined brain regions and sub-regions remains a central focus…”
Get full text