Aerobic exercise prevents cardiomyocyte damage caused by oxidative stress in early cardiovascular disease by increasing vascularity while L-arginine supplementation prevents it by increasing activation of the enzyme nitric oxide synthase

Aerobic exercise prevents cardiomyocyte damage caused by oxidative stress in early cardiovascular disease by increasing vascularity while L-arginine supplementation prevents it by increasing activation of the enzyme nitric oxide synthase

L-Arginine and chronic exercise reduce oxidative stress. However, it is unclear how they affect cardiomyocytes during cardiovascular disease (CVD) development. The aim of this research was to investigate the possible effects of L- arginine supplementation and aerobic training on systemic oxidative s...

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Published in:Brazilian journal of medical and biological research Vol. 56; no. 1; pp. 1 - e12533
Main Authors: Bertoldi, J.M.C.R.J, Kindlovits, R, Rocha, H.N.M, Fernandes-Santos, C, Gomes, J.L.P, Oliveira, E.M, Muniz, I.C, Santos, M.M, Pereira, J.F, Rocha, N.G, da Nobrega, A.C.L, Medeiros, R.F
Format: Journal Article
Language:English
Published: Ribeirao Preto Associacao Brasileira de Divulgacao Cientifica (ABDC) 01-01-2023
Revista Brasileira de Pesquisas Medicas
Associação Brasileira de Divulgação Científica
Subjects:
Aerobic exercises
Aerobics
Arginine
BIOLOGY
Body composition
Body fat
Cardiomyocytes
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Enzyme activation
Exercise
Fructose
Gelatinase A
Health aspects
Heart cells
Hypertrophy
Insulin
Lipid peroxidation
Lipids
MEDICINE, RESEARCH & EXPERIMENTAL
Metalloproteinase
miRNA
Nitric-oxide synthase
Oxidative stress
Oxidoreductases
Physical fitness
Physiological aspects
Tumor necrosis factor-α
Vascularization
Brazil
Oxidative stress
Cardiovascular disease
Exercise
Arginine
Fructose
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Summary:L-Arginine and chronic exercise reduce oxidative stress. However, it is unclear how they affect cardiomyocytes during cardiovascular disease (CVD) development. The aim of this research was to investigate the possible effects of L- arginine supplementation and aerobic training on systemic oxidative stress and their consequences on cardiomyocytes during cardiometabolic disease onset caused by excess fructose. Wistar rats were allocated into four groups: control (C), fructose (F, 10% fructose in water), fructose training (FT; moderate running, 50-70% of the maximal velocity), and fructose arginine (FA; 880 mg/kg/day). Fructose was given for two weeks and fructose plus treatments for the subsequent eight weeks. Body composition, blood glucose, insulin, lipid profile, lipid peroxidation, nitrite, metalloproteinase-2 (MMP-2) activity, left ventricle histological changes, microRNA-126, -195, and -146, eNOS, p-eNOS, and TNF-[alpha] expressions were analyzed. Higher abdominal fat mass, triacylglycerol level, and insulin level were observed in the F group, and both treatments reversed these alterations. Myocardial vascularization was impaired in fructose-fed groups, except in FT. Cardiomyocyte hypertrophy was observed in all fructose-fed groups. TNF-[alpha] levels were higher in fructose-fed groups than in the C group, and p-eNOS levels were higher in the FA than in the C and F groups. Lipid peroxidation was higher in the F group than in the FT and C groups. During CVD onset, moderate aerobic exercise reduced lipid peroxidation, and both training and L-arginine prevented metabolic changes caused by excessive fructose. Myocardial vascularization was impaired by fructose, and cardiomyocyte hypertrophy appeared to be influenced by pro-inflammatory and oxidative environments. Key words: Cardiovascular disease; Exercise; Arginine; Fructose; Oxidative stress
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content type line 23
ISSN:0100-879X
1414-431X
1414-431X
1678-4510
DOI:10.1590/1414-431X2023e12533