Search Results - "Kind, Peter C."

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology by Jiwaji, Zoeb, Tiwari, Sachin S., Avilés-Reyes, Rolando X., Hooley, Monique, Hampton, David, Torvell, Megan, Johnson, Delinda A., McQueen, Jamie, Baxter, Paul, Sabari-Sankar, Kayalvizhi, Qiu, Jing, He, Xin, Fowler, Jill, Febery, James, Gregory, Jenna, Rose, Jamie, Tulloch, Jane, Loan, Jamie, Story, David, McDade, Karina, Smith, Amy M., Greer, Peta, Ball, Matthew, Kind, Peter C., Matthews, Paul M., Smith, Colin, Dando, Owen, Spires-Jones, Tara L., Johnson, Jeffrey A., Chandran, Siddharthan, Hardingham, Giles E.

“…Alzheimer’s disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly understood. TRAP-seq translatome analysis of astrocytes in APP/PS1…”
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Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation by Hristova, Katerina, Martinez-Gonzalez, Cristina, Watson, Thomas C, Codadu, Neela K, Hashemi, Kevan, Kind, Peter C, Nolan, Matthew F, Gonzalez-Sulser, Alfredo

“…Seizures can emerge from multiple or large foci in temporal lobe epilepsy, complicating focally targeted strategies such as surgical resection or the…”
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The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults by Martel, Marc-André, Ryan, Tomás J., Bell, Karen F.S., Fowler, Jill H., McMahon, Aoife, Al-Mubarak, Bashayer, Komiyama, Noboru H., Horsburgh, Karen, Kind, Peter C., Grant, Seth G.N., Wyllie, David J.A., Hardingham, Giles E.

“…It is currently unclear whether the GluN2 subtype influences NMDA receptor (NMDAR) excitotoxicity. We report that the toxicity of NMDAR-mediated Ca2+ influx is…”
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NMDA Receptor C-Terminal Domain Signalling in Development, Maturity, and Disease by Haddow, Kirsty, Kind, Peter C, Hardingham, Giles E

“…The NMDA receptor is a Ca -permeant glutamate receptor which plays key roles in health and disease. Canonical NMDARs contain two GluN2 subunits, of which 2A…”
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Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex by Domanski, Aleksander P. F., Booker, Sam A., Wyllie, David J. A., Isaac, John T. R., Kind, Peter C.

“…Sensory hypersensitivity is a common and debilitating feature of neurodevelopmental disorders such as Fragile X Syndrome (FXS). How developmental changes in…”
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Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome by Asiminas, Antonis, Jackson, Adam D, Louros, Susana R, Till, Sally M, Spano, Teresa, Dando, Owen, Bear, Mark F, Chattarji, Sumantra, Hardingham, Giles E, Osterweil, Emily K, Wyllie, David J A, Wood, Emma R, Kind, Peter C

“…Fragile X Syndrome (FXS) is one of the most common monogenic forms of autism and intellectual disability. Preclinical studies in animal models have highlighted…”
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Altered dendritic spine function and integration in a mouse model of fragile X syndrome by Booker, Sam A., Domanski, Aleksander P. F., Dando, Owen R., Jackson, Adam D., Isaac, John T. R., Hardingham, Giles E., Wyllie, David J. A., Kind, Peter C.

“…Cellular and circuit hyperexcitability are core features of fragile X syndrome and related autism spectrum disorder models. However, the cellular and synaptic…”
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Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome by Thomson, Sophie R., Seo, Sang S., Barnes, Stephanie A., Louros, Susana R., Muscas, Melania, Dando, Owen, Kirby, Caoimhe, Wyllie, David J.A., Hardingham, Giles E., Kind, Peter C., Osterweil, Emily K.

“…Excessive mRNA translation downstream of group I metabotropic glutamate receptors (mGlu1/5) is a core pathophysiology of fragile X syndrome (FX); however, the…”
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Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome by Seo, Sang S., Louros, Susana R., Anstey, Natasha, Gonzalez-Lozano, Miguel A., Harper, Callista B., Verity, Nicholas C., Dando, Owen, Thomson, Sophie R., Darnell, Jennifer C., Kind, Peter C., Li, Ka Wan, Osterweil, Emily K.

“…Dysregulated protein synthesis is a core pathogenic mechanism in Fragile X Syndrome (FX). The mGluR Theory of FX predicts that pathological synaptic changes…”
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Stimulated emission depletion (STED) microscopy reveals nanoscale defects in the developmental trajectory of dendritic spine morphogenesis in a mouse model of fragile X syndrome by Wijetunge, Lasani S, Angibaud, Julie, Frick, Andreas, Kind, Peter C, Nägerl, U Valentin

“…Dendritic spines are basic units of neuronal information processing and their structure is closely reflected in their function. Defects in synaptic development…”
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Characterisation of CDKL5 Transcript Isoforms in Human and Mouse by Hector, Ralph D, Dando, Owen, Landsberger, Nicoletta, Kilstrup-Nielsen, Charlotte, Kind, Peter C, Bailey, Mark E S, Cobb, Stuart R

“…Mutations in the X-linked Cyclin-Dependent Kinase-Like 5 gene (CDKL5) cause early onset infantile spasms and subsequent severe developmental delay in affected…”
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A comparison of basal and activity-dependent exon splicing in cortical-patterned neurons of human and mouse origin by Dando, Owen, McQueen, Jamie, Burr, Karen, Kind, Peter C, Chandran, Siddharthan, Hardingham, Giles E, Qiu, Jing

“…Rodent studies have shown that alternative splicing in neurons plays important roles in development and maturity, and is regulatable by signals such as…”
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Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons by Sharma, Shreya Das, Reddy, Bharath Kumar, Pal, Rakhi, Ritakari, Tuula E., Cooper, James D., Selvaraj, Bhuvaneish T., Kind, Peter C., Chandran, Siddharthan, Wyllie, David J.A., Chattarji, Sumantra

“…Pre-clinical studies of fragile X syndrome (FXS) have focused on neurons, with the role of glia remaining largely underexplored. We examined the astrocytic…”
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Maturation and electrophysiological properties of human pluripotent stem cell‐derived oligodendrocytes by Livesey, Matthew R., Magnani, Dario, Cleary, Elaine M., Vasistha, Navneet A., James, Owain T., Selvaraj, Bhuvaneish T., Burr, Karen, Story, David, Shaw, Christopher E., Kind, Peter C., Hardingham, Giles E., Wyllie, David J.A., Chandran, Siddharthan

“…Rodent‐based studies have shown that the membrane properties of oligodendrocytes play prominent roles in their physiology and shift markedly during their…”
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Sexually dimorphic patterns in electroencephalography power spectrum and autism-related behaviors in a rat model of fragile X syndrome by Wong, Hayes, Hooper, Alexander W.M., Niibori, Yosuke, Lee, Shiron J., Hategan, Luca A., Zhang, Liang, Karumuthil-Melethil, Subha, Till, Sally M., Kind, Peter C., Danos, Olivier, Bruder, Joseph T., Hampson, David R.

“…Fragile X syndrome (FXS), a neurodevelopmental disorder with autistic features, is caused by the loss of the fragile X mental retardation protein. Sex-specific…”
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Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome by Booker, Sam A., Simões de Oliveira, Laura, Anstey, Natasha J., Kozic, Zrinko, Dando, Owen R., Jackson, Adam D., Baxter, Paul S., Isom, Lori L., Sherman, Diane L., Hardingham, Giles E., Brophy, Peter J., Wyllie, David J.A., Kind, Peter C.

“…Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing…”
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Cerebellar contributions to fear-based emotional processing: relevance to understanding the neural circuits involved in autism by Couto-Ovejero, Sabina, Ye, Jingjing, Kind, Peter C, Till, Sally M, Watson, Thomas C

“…Cerebellar networks have traditionally been linked to sensorimotor control. However, a large body of evidence suggests that cerebellar functions extend to…”
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Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome by TILL, Sally M, WIJETUNGE, Lasani S, SEIDEL, Viktoria G, HARLOW, Emily, WRIGHT, Ann K, BAGNI, Claudia, CONTRACTOR, Anis, GILLINGWATER, Thomas H, KIND, Peter C

“…Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and results from the loss of the fragile X mental retardation protein…”
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Identifying foetal forebrain interneurons as a target for monogenic autism risk factors and the polygenic 16p11.2 microdeletion by Yang, Yifei, Booker, Sam A, Clegg, James M, Quintana-Urzainqui, Idoia, Sumera, Anna, Kozic, Zrinko, Dando, Owen, Martin Lorenzo, Sandra, Herault, Yann, Kind, Peter C, Price, David J, Pratt, Thomas

“…Autism spectrum condition or 'autism' is associated with numerous genetic risk factors including the polygenic 16p11.2 microdeletion. The balance between…”
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Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome by Asiminas, Antonis, Booker, Sam A, Dando, Owen R, Kozic, Zrinko, Arkell, Daisy, Inkpen, Felicity H, Sumera, Anna, Akyel, Irem, Kind, Peter C, Wood, Emma R

“…Fragile X syndrome (FXS) is a common single gene cause of intellectual disability and autism spectrum disorder. Cognitive inflexibility is one of the hallmarks…”
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