Search Results - "Kincade, Paul W"

Wnt-Related Molecules and Signaling Pathway Equilibrium in Hematopoiesis by MALHOTRA, Sachin, KINCADE, Paul W

“…There is near consensus that Wnt family molecules establish important gradients within niches where hematopoietic stem cells (HSC) reside. We review recent…”
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The Satb1 Protein Directs Hematopoietic Stem Cell Differentiation toward Lymphoid Lineages by Satoh, Yusuke, Yokota, Takafumi, Sudo, Takao, Kondo, Motonari, Lai, Anne, Kincade, Paul W., Kouro, Taku, Iida, Ryuji, Kokame, Koichi, Miyata, Toshiyuki, Habuchi, Yoko, Matsui, Keiko, Tanaka, Hirokazu, Matsumura, Itaru, Oritani, Kenji, Kohwi-Shigematsu, Terumi, Kanakura, Yuzuru

“…How hematopoietic stem cells (HSCs) produce particular lineages is insufficiently understood. We searched for key factors that direct HSC to lymphopoiesis…”
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Chronic exposure to a TLR ligand injures hematopoietic stem cells by Esplin, Brandt L, Shimazu, Tomoyuki, Welner, Robert S, Garrett, Karla P, Nie, Lei, Zhang, Qingzhao, Humphrey, Mary Beth, Yang, Qi, Borghesi, Lisa A, Kincade, Paul W

“…Hematopoietic stem cells (HSC) can be harmed by disease, chemotherapy, radiation, and normal aging. We show in this study that damage also occurs in mice…”
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Toll-like Receptors on Hematopoietic Progenitor Cells Stimulate Innate Immune System Replenishment by Nagai, Yoshinori, Garrett, Karla P., Ohta, Shoichiro, Bahrun, Uleng, Kouro, Taku, Akira, Shizuo, Takatsu, Kiyoshi, Kincade, Paul W.

“…Toll-like receptors (TLRs) are best known for their ability to recognize microbial or viral components and initiate innate immune responses. We showed here…”
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The Protean Nature of Cells in the B Lymphocyte Lineage by Hardy, Richard R., Kincade, Paul W., Dorshkind, Kenneth

“…The subdivision of bone marrow (BM) with surface markers and reporter systems and the use of multiple culture and transplantation assays to assess…”
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The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells by Ichii, Michiko, Frank, Mark Barton, Iozzo, Renato V., Kincade, Paul W.

“…Considerable information has accumulated about components of BM that regulate the survival, self-renewal, and differentiation of hematopoietic cells. In the…”
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Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 and Cyclin D1 by Lam, Queenie Lai Kwan, Wang, Shengjun, Ko, Otis King Hung, Kincade, Paul W., Lu, Liwei, Mak, Tak Wah

“…Regulation of apoptosis and cell cycle progression plays an essential role in the maintenance of B-cell homeostasis, because a fine balance of survival and…”
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9-1-1: HSCs Respond to Emergency Calls by Welner, Robert S., Kincade, Paul W.

“…In this issue of Cell Stem Cell, Zhao et al. (2014) and Schürch et al. (2014) describe two new stem cell mechanisms underlying protective responses to…”
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Transcription from the RAG1 Locus Marks the Earliest Lymphocyte Progenitors in Bone Marrow by Igarashi, Hideya, Gregory, Sophia C., Yokota, Takafumi, Sakaguchi, Nobuo, Kincade, Paul W.

“…Viable Lin − CD27 + c-kit Hi Sca-1 Hi GFP + cells recovered from heterozygous RAG1/GFP knockin mice progressed through previously defined stages of B, T, and…”
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differentiation pathway for B1 cells in adult bone marrow by Esplin, Brandt L, Welner, Robert S, Zhang, Qingzhao, Borghesi, Lisa A, Kincade, Paul W

“…The recent description of a Lin⁻AA4.1⁺CD19⁺B220Lo/⁻ B1-specified progenitor (B1P) population in adult marrow adds support for the argument that these unique B…”
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The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice by Yokota, Takafumi, Oritani, Kenji, Butz, Stefan, Kokame, Koichi, Kincade, Paul W., Miyata, Toshiyuki, Vestweber, Dietmar, Kanakura, Yuzuru

“…Although recent advances have enabled hematopoietic stem cells (HSCs) to be enriched to near purity, more information about their characteristics will improve…”
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Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection by Welner, Robert S., Pelayo, Rosana, Nagai, Yoshinori, Garrett, Karla P., Wuest, Todd R., Carr, Daniel J., Borghesi, Lisa A., Farrar, Michael A., Kincade, Paul W.

“…Hematopoietic stem and progenitor cells were previously found to express Toll-like receptors (TLRs), suggesting that bacterial/viral products may influence…”
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CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential by Shimazu, Tomoyuki, Iida, Ryuji, Zhang, Qingzhao, Welner, Robert S., Medina, Kay L., Alberola-lla, José, Kincade, Paul W.

“…A unique subset of CD86− HSCs was previously discovered in mice that were old or chronically stimulated with lipopolysaccharide. Functionally defective HSCs…”
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Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells by Malhotra, Sachin, Kincade, Paul W

“…Objective The Wnt family may contribute to hematopoietic stem cell (HSC) maintenance in bone marrow, but many questions remain concerning mechanisms. Vascular…”
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Derivation of 2 categories of plasmacytoid dendritic cells in murine bone marrow by Pelayo, Rosana, Hirose, Jun, Huang, Jiaxue, Garrett, Karla P., Delogu, Alessio, Busslinger, Meinrad, Kincade, Paul W.

“…Plasmacytoid dendritic cells (pDCs) competent to make type I interferon were rigorously defined as a Ly-6C+ and CD11cLo subset of the B220+CD19- CD43+CD24Lo…”
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Contrasting Responses of Lymphoid Progenitors to Canonical and Noncanonical Wnt Signals by Malhotra, Sachin, Baba, Yoshihiro, Garrett, Karla P, Staal, Frank J. T, Gerstein, Rachel, Kincade, Paul W

“…The Wnt family of secreted glycoproteins has been implicated in many aspects of development, but its contribution to blood cell formation is controversial. We…”
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The density of CD10 corresponds to commitment and progression in the human B lymphoid lineage by Ichii, Michiko, Oritani, Kenji, Yokota, Takafumi, Zhang, Qingzhao, Garrett, Karla P, Kanakura, Yuzuru, Kincade, Paul W

“…Requirements for human B lymphopoiesis are still poorly understood, and that has hampered investigation of differentiation events. For example, there are few…”
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Plasticity of Supporting Cells in a Stem Cell Factory by Kincade, Paul W.

“…In this issue of Immunity, Omatsu et al. (2010) provide new information on the CXCL12 abundant reticular (CAR) cells that support hematopoietic stem cells and…”
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Retinoids Accelerate B Lineage Lymphoid Differentiation by Chen, Xinrong, Esplin, Brandt L, Garrett, Karla P, Welner, Robert S, Webb, Carol F, Kincade, Paul W

“…Retinoids are known to have potent effects on hemopoietic stem cell integrity, and our objective was to learn whether they influence cells destined to…”
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Replenishing B lymphocytes in health and disease by Zhang, Qingzhao, Iida, Ryuji, Shimazu, Tomoyuki, Kincade, Paul W

“…Highlights ► Hematopoietic stems cells are more heterogeneous than previously thought. ► B lineage commitment is gradual and unsynchronized. ► B lymphopoiesis…”
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