Search Results - "Kin-Hang Kok"

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan by Chan, Jasper Fuk-Woo, Kok, Kin-Hang, Zhu, Zheng, Chu, Hin, To, Kelvin Kai-Wang, Yuan, Shuofeng, Yuen, Kwok-Yung

“…A mysterious outbreak of atypical pneumonia in late 2019 was traced to a seafood wholesale market in Wuhan of China. Within a few weeks, a novel coronavirus…”
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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster by Chan, Jasper Fuk-Woo, Yuan, Shuofeng, Kok, Kin-Hang, To, Kelvin Kai-Wang, Chu, Hin, Yang, Jin, Xing, Fanfan, Liu, Jieling, Yip, Cyril Chik-Yan, Poon, Rosana Wing-Shan, Tsoi, Hoi-Wah, Lo, Simon Kam-Fai, Chan, Kwok-Hung, Poon, Vincent Kwok-Man, Chan, Wan-Mui, Ip, Jonathan Daniel, Cai, Jian-Piao, Cheng, Vincent Chi-Chung, Chen, Honglin, Hui, Christopher Kim-Ming, Yuen, Kwok-Yung

“…An ongoing outbreak of pneumonia associated with a novel coronavirus was reported in Wuhan city, Hubei province, China. Affected patients were geographically…”
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Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility by Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Lee, Andrew Chak-Yiu, Chan, Wan-Mui, Fan, Zhimeng, Tsoi, Hoi-Wah, Wen, Lei, Liang, Ronghui, Cao, Jianli, Chen, Yanxia, Tang, Kaiming, Luo, Cuiting, Cai, Jian-Piao, Kok, Kin-Hang, Chu, Hin, Chan, Kwok-Hung, Sridhar, Siddharth, Chen, Zhiwei, Chen, Honglin, To, Kelvin Kai-Wang, Yuen, Kwok-Yung

“…Abstract Background A physiological small-animal model that resembles COVID-19 with low mortality is lacking. Methods Molecular docking on the binding between…”
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Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing by To, Kelvin Kai-Wang, Hung, Ivan Fan-Ngai, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Chan, Wan-Mui, Tam, Anthony Raymond, Fong, Carol Ho-Yan, Yuan, Shuofeng, Tsoi, Hoi-Wah, Ng, Anthony Chin-Ki, Lee, Larry Lap-Yip, Wan, Polk, Tso, Eugene Yuk-Keung, To, Wing-Kin, Tsang, Dominic Ngai-Chong, Chan, Kwok-Hung, Huang, Jian-Dong, Kok, Kin-Hang, Cheng, Vincent Chi-Chung, Yuen, Kwok-Yung

“…Abstract Background Waning immunity occurs in patients who have recovered from Coronavirus Disease 2019 (COVID-19). However, it remains unclear whether true…”
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Suppression of SARS‐CoV‐2 infection in ex‐vivo human lung tissues by targeting class III phosphoinositide 3‐kinase by Yuen, Chun‐Kit, Wong, Wan‐Man, Mak, Long‐Fung, Wang, Xiaohui, Chu, Hin, Yuen, Kwok‐Yung, Kok, Kin‐Hang

“…The novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) emerged at the end of 2019 and caused the coronavirus disease 19…”
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Clofazimine broadly inhibits coronaviruses including SARS-CoV-2 by Yuan, Shuofeng, Yin, Xin, Meng, Xiangzhi, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Riva, Laura, Pache, Lars, Chan, Chris Chun-Yiu, Lai, Pok-Man, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Lee, Andrew Chak-Yiu, Matsunaga, Naoko, Pu, Yuan, Yuen, Chun-Kit, Cao, Jianli, Liang, Ronghui, Tang, Kaiming, Sheng, Li, Du, Yushen, Xu, Wan, Lau, Chit-Ying, Sit, Ko-Yung, Au, Wing-Kuk, Wang, Runming, Zhang, Yu-Yuan, Tang, Yan-Dong, Clausen, Thomas Mandel, Pihl, Jessica, Oh, Juntaek, Sze, Kong-Hung, Zhang, Anna Jinxia, Chu, Hin, Kok, Kin-Hang, Wang, Dong, Cai, Xue-Hui, Esko, Jeffrey D., Hung, Ivan Fan-Ngai, Li, Ronald Adolphus, Chen, Honglin, Sun, Hongzhe, Jin, Dong-Yan, Sun, Ren, Chanda, Sumit K., Yuen, Kwok-Yung

“…The COVID-19 pandemic is the third outbreak this century of a zoonotic disease caused by a coronavirus, following the emergence of severe acute respiratory…”
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SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target by Yuan, Shuofeng, Chu, Hin, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Wen, Lei, Yan, Bingpeng, Lai, Pok-Man, Tee, Kah-Meng, Huang, Jingjing, Chen, Dongdong, Li, Cun, Zhao, Xiaoyu, Yang, Dong, Chiu, Man Chun, Yip, Cyril, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Sze, Kong-Hung, Zhou, Jie, Chan, Ivy Hau-Yee, Kok, Kin-Hang, To, Kelvin Kai-Wang, Kao, Richard Yi-Tsun, Lau, Johnson Yiu-Nam, Jin, Dong-Yan, Perlman, Stanley, Yuen, Kwok-Yung

“…Viruses are obligate intracellular microbes that exploit the host metabolic machineries to meet their biosynthetic demands, making these host pathways…”
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Intravenous Injection of Coronavirus Disease 2019 (COVID-19) mRNA Vaccine Can Induce Acute Myopericarditis in Mouse Model by Li, Can, Chen, Yanxia, Zhao, Yan, Lung, David Christopher, Ye, Zhanhong, Song, Wenchen, Liu, Fei-Fei, Cai, Jian-Piao, Wong, Wan-Man, Yip, Cyril Chik-Yan, Chan, Jasper Fuk-Woo, To, Kelvin Kai-Wang, Sridhar, Siddharth, Hung, Ivan Fan-Ngai, Chu, Hin, Kok, Kin-Hang, Jin, Dong-Yan, Zhang, Anna Jinxia, Yuen, Kwok-Yung

“…Abstract Background Post-vaccination myopericarditis is reported after immunization with coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines. The…”
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Host and viral determinants for efficient SARS-CoV-2 infection of the human lung by Chu, Hin, Hu, Bingjie, Huang, Xiner, Chai, Yue, Zhou, Dongyan, Wang, Yixin, Shuai, Huiping, Yang, Dong, Hou, Yuxin, Zhang, Xi, Yuen, Terrence Tsz-Tai, Cai, Jian-Piao, Zhang, Anna Jinxia, Zhou, Jie, Yuan, Shuofeng, To, Kelvin Kai-Wang, Chan, Ivy Hau-Yee, Sit, Ko-Yung, Foo, Dominic Chi-Chung, Wong, Ian Yu-Hong, Ng, Ada Tsui-Lin, Cheung, Tan To, Law, Simon Ying-Kit, Au, Wing-Kuk, Brindley, Melinda A., Chen, Zhiwei, Kok, Kin-Hang, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung

“…Understanding the factors that contribute to efficient SARS-CoV-2 infection of human cells may provide insights on SARS-CoV-2 transmissibility and…”
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Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study by Chu, Hin, Chan, Jasper Fuk-Woo, Yuen, Terrence Tsz-Tai, Shuai, Huiping, Yuan, Shuofeng, Wang, Yixin, Hu, Bingjie, Yip, Cyril Chik-Yan, Tsang, Jessica Oi-Ling, Huang, Xiner, Chai, Yue, Yang, Dong, Hou, Yuxin, Chik, Kenn Ka-Heng, Zhang, Xi, Fung, Agnes Yim-Fong, Tsoi, Hoi-Wah, Cai, Jian-Piao, Chan, Wan-Mui, Ip, Jonathan Daniel, Chu, Allen Wing-Ho, Zhou, Jie, Lung, David Christopher, Kok, Kin-Hang, To, Kelvin Kai-Wang, Tsang, Owen Tak-Yin, Chan, Kwok-Hung, Yuen, Kwok-Yung

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported from China in January, 2020. SARS-CoV-2 is efficiently transmitted from person to…”
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Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16 by Wang, Pei‐Hui, Ye, Zi‐Wei, Deng, Jian‐Jun, Siu, Kam‐Leung, Gao, Wei‐Wei, Chaudhary, Vidyanath, Cheng, Yun, Fung, Sin‐Yee, Yuen, Kit‐San, Ho, Ting‐Hin, Chan, Ching‐Ping, Zhang, Yan, Kok, Kin‐Hang, Yang, Wanling, Chan, Chi‐Ping, Jin, Dong‐Yan

“…Mouse p202 is a disease locus for lupus and a dominant‐negative inhibitor of AIM2 inflammasome activation. A human homolog of p202 has not been identified so…”
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Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection by Wang, Xiaohui, Lin, Xiang, Zheng, Zihan, Lu, Bingtai, Wang, Jun, Tan, Andy Hee-Meng, Zhao, Meng, Loh, Jia Tong, Ng, Sze Wai, Chen, Qian, Xiao, Fan, Huang, Enyu, Ko, King-Hung, Huang, Zhong, Li, Jingyi, Kok, Kin-Hang, Lu, Gen, Liu, Xiaohui, Lam, Kong-Peng, Liu, Wanli, Zhang, Yuxia, Yuen, Kwok-Yung, Mak, Tak Wah, Lu, Liwei

“…Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids…”
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PACT Facilitates RNA-Induced Activation of MDA5 by Promoting MDA5 Oligomerization by Lui, Pak-Yin, Wong, Lok-Yin Roy, Ho, Ting-Hin, Au, Shannon Wing Ngor, Chan, Chi-Ping, Kok, Kin-Hang, Jin, Dong-Yan

“…MDA5 is a RIG-I-like cytoplasmic sensor of dsRNA and certain RNA viruses, such as encephalomyocarditis virus, for the initiation of the IFN signaling cascade…”
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Identification of nsp1 gene as the target of SARS‐CoV‐2 real‐time RT‐PCR using nanopore whole‐genome sequencing by Chan, Wan‐Mui, Ip, Jonathan Daniel, Chu, Allen Wing‐Ho, Yip, Cyril Chik‐Yan, Lo, Lap‐Sum, Chan, Kwok‐Hung, Ng, Anthony Chin‐Ki, Poon, Rosana Wing‐Shan, To, Wing‐Kin, Tsang, Owen Tak‐Yin, Leung, Wai‐Shing, Kwan, Mike Yat‐Wah, Chua, Gilbert T., Chung, Tom Wai‐Hin, Hung, Ivan Fan‐Ngai, Kok, Kin‐Hang, Cheng, Vincent Chi‐Chung, Chan, Jasper Fuk‐Woo, Yuen, Kwok‐Yung, To, Kelvin Kai‐Wang

“…Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has caused the coronavirus disease 2019 (COVID‐19) pandemic. Accurate detection of SARS‐CoV‐2…”
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Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection by Lee, Suki M. Y., Kok, Kin-Hang, Jaume, Martial, Cheung, Timothy K. W., Yip, Tsz-Fung, Lai, Jimmy C. C., Yi Guan, Webster, Robert G., Jin, Dong-Yan, Peiris, J. S. Malik

“…Toll-like receptors (TLRs) play key roles in innate immune recognition of pathogen-associated molecular patterns of invading microbes. Among the 10 TLR family…”
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Accurate Diagnosis of COVID-19 by a Novel Immunogenic Secreted SARS-CoV-2 orf8 Protein by Wang, Xiaohui, Lam, Joy-Yan, Wong, Wan-Man, Yuen, Chun-Kit, Cai, Jian-Piao, Au, Shannon Wing-Ngor, Chan, Jasper Fuk-Woo, To, Kelvin K W, Kok, Kin-Hang, Yuen, Kwok-Yung

“…An accurate diagnostic test for early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the key weapon to control the coronavirus…”
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Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice by Lau, Susanna K. P., Fan, Rachel Y. Y., Zhu, Longchao, Li, Kenneth S. M., Wong, Antonio C. P., Luk, Hayes K. H., Wong, Emily Y. M., Lam, Carol S. F., Lo, George C. S., Fung, Joshua, He, Zirong, Fok, Felix C. H., Au-Yeung, Rex K. H., Zhang, Libiao, Kok, Kin-Hang, Yuen, Kwok-Yung, Woo, Patrick C. Y.

“…While a number of human coronaviruses are believed to be originated from ancestral viruses in bats, it remains unclear if bat coronaviruses are ready to cause…”
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An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival by Choy, Elizabeth Yee-Wai, Siu, Kam-Leung, Kok, Kin-Hang, Lung, Raymond Wai-Ming, Tsang, Chi Man, To, Ka-Fai, Kwong, Dora Lai-Wan, Tsao, Sai Wah, Jin, Dong-Yan

“…Epstein-Barr virus (EBV) is a herpesvirus associated with nasopharyngeal carcinoma (NPC), gastric carcinoma (GC), and other malignancies. EBV is the first…”
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Targeting of DICE1 tumor suppressor by Epstein–Barr virus‐encoded miR‐BART3 microRNA in nasopharyngeal carcinoma by Lei, Ting, Yuen, Kit‐San, Xu, Rui, Tsao, Sai Wah, Chen, Honglin, Li, Mengfeng, Kok, Kin‐Hang, Jin, Dong‐Yan

“…Latent infection with Epstein–Barr virus (EBV) is associated with several types of malignancies including nasopharyngeal carcinoma (NPC), which is particularly…”
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An interferon-integrated mucosal vaccine provides pan-sarbecovirus protection in small animal models by Yuen, Chun-Kit, Wong, Wan-Man, Mak, Long-Fung, Lam, Joy-Yan, Cheung, Lok-Yi, Cheung, Derek Tsz-Yin, Ng, Yau-Yee, Lee, Andrew Chak-Yiu, Zhong, Nanshan, Yuen, Kwok-Yung, Kok, Kin-Hang

“…A pan-sarbecovirus or pan-betacoronavirus vaccine that can prevent current and potential future beta-coronavirus infections is important for fighting possible…”
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