Comparison of the effects of omeprazole and famotidine in treatment of upper abdominal symptoms in patients with reflux esophagitis

Purpose The purpose of this study was to compare the efficacy of proton pump inhibitor (PPI) with H₂ receptor antagonist (H₂RA) in treatment of upper abdominal symptoms. Methods This was a multi-center, open study conducted at 102 hospitals in Japan. Patients with reflux esophagitis received famotid...

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Bibliographic Details
Published in:	Journal of gastroenterology Vol. 44; no. 4; pp. 261 - 270
Main Authors:	Kusunoki, Hiroaki, Kusaka, Masayasu, Kido, Soichiro, Yamauchi, Ryo, Fujimura, Yoshinori, Watanabe, Yasuyuki, Kobori, Michio, Miwa, Hiroto, Tomita, Toshihiko, Kin, Yongmin, Hori, Kazutoshi, Tano, Nobuo, Sugimoto, Kenji, Nakamura, Yoshihiro, Fujimoto, Kazuma, Oza, Noriko, Matsunobu, Aki, Ono, Naofumi, Fuyuno, Seisuke, Kinoshita, Yoshikazu, Adachi, Kyoichi, Yuki, Mika, Fujisawa, Tomoo, Haruma, Ken
Format:	Journal Article
Language:	English
Published:	Japan Japan : Springer Japan 01-04-2009 Springer Japan Springer Nature B.V
Subjects:	Abdominal Surgery Adult Aged Anti-Ulcer Agents - therapeutic use Colorectal Surgery Esophagitis, Peptic - drug therapy Famotidine - therapeutic use Female Gastroenterology Hepatology Histamine H2 Antagonists - therapeutic use Humans Male Medicine Medicine & Public Health Middle Aged Omeprazole - therapeutic use Original Article—Alimentary Tract Proton Pump Inhibitors - therapeutic use Severity of Illness Index Surgical Oncology Surveys and Questionnaires Young Adult Omeprazole Famotidine Upper abdominal symptoms
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Summary:	Purpose The purpose of this study was to compare the efficacy of proton pump inhibitor (PPI) with H₂ receptor antagonist (H₂RA) in treatment of upper abdominal symptoms. Methods This was a multi-center, open study conducted at 102 hospitals in Japan. Patients with reflux esophagitis received famotidine 10 mg twice daily for 2 weeks, then omeprazole 10 mg once daily for 2 weeks. Thereafter, patients were switched to famotidine 10 mg twice daily for a third 2-weekperiod, provided those with a medical condition agreed to continue the study. Patients evaluated the treatment response to each gastrointestinal symptom using a predefined patient questionnaire and gastrointestinal symptom rating scale (GSRS). Results 161 patients entered the study, of whom 8 were excluded from all analyses due to lack of participation following entry. Overall symptom improvement rate (n = 130) at week 4, after the 2-week omeprazole treatment, was 75.4% and this was significantly higher than that after the first 2-week famotidine treatment (41.5%) at week 2. In patients (n = 36) who completed 6 weeks of treatment, 2-week omeprazole treatment at week 4 showed a significantly higher overall symptom improvement rate compared with both the first 2-week and third 2-week famotidine treatments. Conclusions Omeprazole was superior to famotidine for treatment of upper abdominal symptoms in patients with reflux esophagitis, which suggested that gastric acid might be a cause not only of reflux symptoms, but also of ulcer symptoms and dysmotility symptoms such as epigastric pain and feeling of fullness in reflux esophagitis.
Bibliography:	http://dx.doi.org/10.1007/s00535-009-0003-4
ISSN:	0944-1174 1435-5922
DOI:	10.1007/s00535-009-0003-4