Search Results - "Kimura, Hiroaki"

Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure by Yamada, Naoya, Karasawa, Tadayoshi, Kimura, Hiroaki, Watanabe, Sachiko, Komada, Takanori, Kamata, Ryo, Sampilvanjil, Ariunaa, Ito, Junya, Nakagawa, Kiyotaka, Kuwata, Hiroshi, Hara, Shuntaro, Mizuta, Koichi, Sakuma, Yasunaru, Sata, Naohiro, Takahashi, Masafumi

“…Acetaminophen (APAP) overdose is a common cause of drug-induced acute liver failure. Although hepatocyte cell death is considered to be the critical event in…”
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Iron overload as a risk factor for hepatic ischemia‐reperfusion injury in liver transplantation: Potential role of ferroptosis by Yamada, Naoya, Karasawa, Tadayoshi, Wakiya, Taiichi, Sadatomo, Ai, Ito, Homare, Kamata, Ryo, Watanabe, Sachiko, Komada, Takanori, Kimura, Hiroaki, Sanada, Yukihiro, Sakuma, Yasunaru, Mizuta, Koichi, Ohno, Nobuhiko, Sata, Naohiro, Takahashi, Masafumi

“…Hepatic ischemia‐reperfusion (I/R) injury is a major problem in liver transplantation (LT). Although hepatocyte cell death is the initial event in hepatic I/R…”
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ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages by Kawashima, Akira, Karasawa, Tadayoshi, Tago, Kenji, Kimura, Hiroaki, Kamata, Ryo, Usui-Kawanishi, Fumitake, Watanabe, Sachiko, Ohta, Satoshi, Funakoshi-Tago, Megumi, Yanagisawa, Ken, Kasahara, Tadashi, Suzuki, Koichi, Takahashi, Masafumi

“…The nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a molecular platform that induces…”
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Effect of indirect neural decompression through oblique lateral interbody fusion for degenerative lumbar disease by Fujibayashi, Shunsuke, Hynes, Richard A, Otsuki, Bungo, Kimura, Hiroaki, Takemoto, Mitsuru, Matsuda, Shuichi

“…Prospective consecutive clinical study to assess the decompressive benefit and outcome of oblique lateral interbody fusion for lumbar degenerative diseases. To…”
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Generation of narrow-band X-ray free-electron laser via reflection self-seeding by Inoue, Ichiro, Osaka, Taito, Hara, Toru, Tanaka, Takashi, Inagaki, Takahiro, Fukui, Toru, Goto, Shunji, Inubushi, Yuichi, Kimura, Hiroaki, Kinjo, Ryota, Ohashi, Haruhiko, Togawa, Kazuaki, Tono, Kensuke, Yamaga, Mitsuhiro, Tanaka, Hitoshi, Ishikawa, Tetsuya, Yabashi, Makina

“…X-ray free-electron lasers (XFELs) 1 , 2 are widely operated on the basis of self-amplified spontaneous emission (SASE) 3 , 4 , where spontaneous radiation…”
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What Is the Revision-free Survival of Resurfaced Allograft-prosthesis Composites for Proximal Humerus Reconstruction in Children With Bone Tumors? by Errani, Costantino, Aiba, Hisaki, Atherley, Ahmed, Palmas, Marco, Kimura, Hiroaki, Donati, Davide Maria, Manfrini, Marco

“…Reconstruction of the proximal humerus in children who undergo bone tumor resection is challenging because of patients' small bone size and possible limb…”
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New Insights into the Function of the Immunoproteasome in Immune and Nonimmune Cells by Suzuki, Koichi, Takahashi, M., Caturegli, Patrizio, Kimura, Hiroaki

“…The immunoproteasome is a highly efficient proteolytic machinery derived from the constitutive proteasome and is abundantly expressed in immune cells. The…”
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Analysis of the Factors Affecting Lumbar Segmental Lordosis After Lateral Lumbar Interbody Fusion by Otsuki, Bungo, Fujibayashi, Shunsuke, Takemoto, Mitsuru, Kimura, Hiroaki, Shimizu, Takayoshi, Murata, Koichi, Matsuda, Shuichi

“…STUDY DESIGN.Retrospective study. OBJECTIVE.To elucidate factors that determine segmental lordosis after lateral retroperitoneal lumbar interbody fusion (LLIF)…”
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Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages by Karasawa, Tadayoshi, Kawashima, Akira, Usui-Kawanishi, Fumitake, Watanabe, Sachiko, Kimura, Hiroaki, Kamata, Ryo, Shirasuna, Koumei, Koyama, Yutaro, Sato-Tomita, Ayana, Matsuzaka, Takashi, Tomoda, Hiroshi, Park, Sam-Yong, Shibayama, Naoya, Shimano, Hitoshi, Kasahara, Tadashi, Takahashi, Masafumi

“…OBJECTIVE—Inflammation provoked by the imbalance of fatty acid composition, such as excess saturated fatty acids (SFAs), is implicated in the development of…”
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Inflammasome Activation by Mitochondrial Oxidative Stress in Macrophages Leads to the Development of Angiotensin II–Induced Aortic Aneurysm by Usui, Fumitake, Shirasuna, Koumei, Kimura, Hiroaki, Tatsumi, Kazuki, Kawashima, Akira, Karasawa, Tadayoshi, Yoshimura, Koichi, Aoki, Hiroki, Tsutsui, Hiroko, Noda, Tetsuo, Sagara, Junji, Taniguchi, Shun’ichiro, Takahashi, Masafumi

“…OBJECTIVE—Abdominal aortic aneurysm (AAA) is considered a chronic inflammatory disease; however, the molecular basis underlying the sterile inflammatory…”
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The combination of oral-recombinant methioninase and azacitidine arrests a chemotherapy-resistant osteosarcoma patient-derived orthotopic xenograft mouse model by Higuchi, Takashi, Sugisawa, Norihiko, Yamamoto, Jun, Oshiro, Hiromichi, Han, Qinghong, Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Igarashi, Kentaro, Tan, Yuying, Kuchipudi, Shreya, Bouvet, Michael, Singh, Shree Ram, Tsuchiya, Hiroyuki, Hoffman, Robert M.

“…Purpose Cancers are methionine (MET) and methylation addicted, causing them to be highly sensitive to MET restriction. The present study determined the…”
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Reliability of joint position sense measured in the knee using the level function of the iPhone "Measure" application by Nakashima, Yuki, Iwaki, Daisuke, Kawae, Toshihiro, Fudeyasu, Kenichi, Kimura, Hiroaki

“…An impaired joint position sense (JPS) causes activity limitations, postural imbalance, and falls. This study compares the reliability of knee JPS measurements…”
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Analysis of cancer-associated fibroblasts and the epithelial-mesenchymal transition in cutaneous basal cell carcinoma, squamous cell carcinoma, and malignant melanoma by Sasaki, Kousuke, Sugai, Tamotsu, Ishida, Kazuyuki, Osakabe, Mitsumasa, Amano, Hiroo, Kimura, Hiroaki, Sakuraba, Minoru, Kashiwa, Katsuhiko, Kobayashi, Seiichiro

“…Activated cancer-associated fibroblasts (CAFs) and fibroblasts that have undergone the epithelial-mesenchymal transition (EMT) in cancer stroma contribute to…”
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Effectiveness of ultrasound-guided fascia hydrorelease on the coracohumeral ligament in patients with global limitation of the shoulder range of motion: a pilot study by Kimura, Hiroaki, Suda, Masei, Kobayashi, Tadashi, Suzuki, Shigeki, Fukui, Sho, Obata, Hideaki

“…We conducted a prospective single-arm interventional study of the treatment efficacy of ultrasound-guided fascia hydrorelease (US-FHR) on the coracohumeral…”
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Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease by Anzai, Fumiya, Watanabe, Sachiko, Kimura, Hiroaki, Kamata, Ryo, Karasawa, Tadayoshi, Komada, Takanori, Nakamura, Jun, Nagi-miura, Noriko, Ohno, Naohito, Takeishi, Yasuchika, Takahashi, Masafumi

“…Kawasaki disease (KD) is a systemic febrile syndrome during childhood that is characterized by coronary arteritis. The etiopathogenesis of KD remains to be…”
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Osteosarcoma Patient-derived Orthotopic Xenograft (PDOX) Models Used to Identify Novel and Effective Therapeutics: A Review by HIGUCHI, TAKASHI, IGARASHI, KENTARO, YAMAMOTO, NORIO, HAYASHI, KATSUHIRO, KIMURA, HIROAKI, MIWA, SHINJI, BOUVET, MICHAEL, TSUCHIYA, HIROYUKI, HOFFMAN, ROBERT M.

“…Background/Aim: Recurrent osteosarcoma is recalcitrant with poor response rates to first-line chemotherapy due to heterogeneity and metastatic potential. This…”
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Deletion of inflammasome adaptor protein ASC enhances functional recovery after spinal cord injury in mice by Shiraishi, Yasuyuki, Kimura, Atsushi, Kimura, Hiroaki, Ohmori, Tsukasa, Takahashi, Masafumi, Takeshita, Katsushi

“…Research has revealed the crucial roles of inflammasomes in various central nervous system disorders. However, the role of inflammasomes in secondary damage…”
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Risk Factors for Cage Retropulsion After Posterior Lumbar Interbody Fusion: Analysis of 1070 Cases by KIMURA, Hiroaki, SHIKATA, Jitsuhiko, ODATE, Seiichi, SOEDA, Tsunemitsu, YAMAMURA, Satoru

“…Single-center retrospective study. We examined the risk factors for cage retropulsion after posterior lumbar interbody fusion (PLIF) performed for patients…”
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Glucose regulates hypoxia‐induced NLRP3 inflammasome activation in macrophages by Watanabe, Sachiko, Usui‐Kawanishi, Fumitake, Karasawa, Tadayoshi, Kimura, Hiroaki, Kamata, Ryo, Komada, Takanori, Inoue, Yoshiyuki, Mise, Nathan, Kasahara, Tadashi, Takahashi, Masafumi

“…Although the intimate linkage between hypoxia and inflammation is well known, the mechanism underlying this linkage has not been fully understood…”
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NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury by Ito, Homare, Kimura, Hiroaki, Karasawa, Tadayoshi, Hisata, Shu, Sadatomo, Ai, Inoue, Yoshiyuki, Yamada, Naoya, Aizawa, Emi, Hishida, Erika, Kamata, Ryo, Komada, Takanori, Watanabe, Sachiko, Kasahara, Tadashi, Suzuki, Takuji, Horie, Hisanaga, Kitayama, Joji, Sata, Naohiro, Yamaji-Kegan, Kazuyo, Takahashi, Masafumi

“…Intestinal ischemia/reperfusion (I/R) injury is a life-threatening complication that leads to inflammation and remote organ damage. The NLRP3 inflammasome…”
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