Search Results - "Kimoto, Masao"

Essential role of MD-2 in LPS responsiveness and TLR4 distribution by Miyake, Kensuke, Nagai, Yoshinori, Akashi, Sachiko, Nagafuku, Masakazu, Ogata, Masato, Iwakura, Yoichiro, Akira, Shizuo, Kitamura, Toshio, Kosugi, Atsushi, Kimoto, Masao

“…Toll-like receptor 4 (TLR4) mediates lipopolysaccharide (LPS) signaling in a variety of cell types. MD-2 is associated with the extracellular domain of TLR4…”
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Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells by Tsukamoto, Hiroki, Fukudome, Kenji, Takao, Shoko, Tsuneyoshi, Naoko, Kimoto, Masao

“…Toll-like receptor (TLR) 4/MD-2 dimerization is thought to be required for the initiation of signaling during innate immune responses. In this study, we…”
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Leucine-rich repeat 2 of human Toll-like receptor 4 contains the binding site for inhibitory monoclonal antibodies by Tsukamoto, Hiroki, Ukai, Ippo, Yamagata, Yuki, Takeuchi, Shino, Kubota, Kanae, Kozakai, Sao, Suzuki, Naoto, Kimoto, Masao, Tomioka, Yoshihisa

“…•A novel anti-TLR4 mAb HTB2 was obtained by cross-block screening against HT52.•HTB2 inhibits LPS-induced TLR4 activation.•HT52 and HTB2 epitopes were…”
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Reduced surface expression of TLR4 by a V254I point mutation accounts for the low lipopolysaccharide responder phenotype of BALB/c B cells by Tsukamoto, Hiroki, Fukudome, Kenji, Takao, Shoko, Tsuneyoshi, Naoko, Ohta, Shoichiro, Nagai, Yoshinori, Ihara, Hideyuki, Miyake, Kensuke, Ikeda, Yoshitaka, Kimoto, Masao

“…LPS is recognized by TLR4 and radioprotective 105 kDa in B cells. Susceptibility to LPS in murine B cells is most closely linked to the locus containing the…”
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Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs by Tsukamoto, Hiroki, Fukudome, Kenji, Takao, Shoko, Tsuneyoshi, Naoko, Ihara, Hideyuki, Ikeda, Yoshitaka, Kimoto, Masao

“…Recognition of LPS by the toll-like receptor 4 (TLR4)/MD-2 complex is a trigger of innate immune defense against bacterial invasion. However, excessive immune…”
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Cutting Edge: Cell Surface Expression and Lipopolysaccharide Signaling Via the Toll-Like Receptor 4-MD-2 Complex on Mouse Peritoneal Macrophages by Akashi, Sachiko, Shimazu, Rintaro, Ogata, Hirotaka, Nagai, Yoshinori, Takeda, Kiyoshi, Kimoto, Masao, Miyake, Kensuke

“…The human MD-2 molecule is associated with the extracellular domain of human Toll-like receptor 4 (TLR4) and greatly enhances its LPS signaling. The human…”
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Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells by Matsushita, Hidetomo, Ohta, Shoichiro, Shiraishi, Hiroshi, Suzuki, Shoichi, Arima, Kazuhiko, Toda, Shuji, Tanaka, Hiroyuki, Nagai, Hiroichi, Kimoto, Masao, Inokuchi, Akira, Izuhara, Kenji

“…Prior exposure of dendritic cells (DCs) and monocytes/macrophages to LPS causes unresponsiveness to subsequent LPS stimulation, a phenomenon called endotoxin…”
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The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells by Ogata, H, Su, I, Miyake, K, Nagai, Y, Akashi, S, Mecklenbräuker, I, Rajewsky, K, Kimoto, M, Tarakhovsky, A

“…The susceptibility to infections induced by Gram-negative bacteria is largely determined by innate immune responses to bacteria cell wall lipopolysaccharide…”
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Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition by Akashi, Sachiko, Nagai, Yoshinori, Ogata, Hirotaka, Oikawa, Masato, Fukase, Koichi, Kusumoto, Shoichi, Kawasaki, Kiyoshi, Nishijima, Masahiro, Hayashi, Shinichiro, Kimoto, Masao, Miyake, Kensuke

“…Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide (LPS). MD-2 is associated with TLR4 and imparts LPS responsiveness to it. Little is known, however,…”
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The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells by Nagai, Yoshinori, Yanagibashi, Tsutomu, Watanabe, Yasuharu, Ikutani, Masashi, Kariyone, Ai, Ohta, Shoichiro, Hirai, Yoshikatsu, Kimoto, Masao, Miyake, Kensuke, Takatsu, Kiyoshi

“…Marginal zone (MZ) B cells mount rapid T-cell-independent (T-I) immune responses against microbial components such as LPS. While Toll-like receptor 4 (TLR4) is…”
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Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide by Nagai, Yoshinori, Shimazu, Rintaro, Ogata, Hirotaka, Akashi, Sachiko, Sudo, Katsuko, Yamasaki, Hidetoshi, Hayashi, Shin-Ichi, Iwakura, Yoichiro, Kimoto, Masao, Miyake, Kensuke

“…RP105 is a B-cell surface molecule that has been recently assigned as CD180. RP105 ligation with an antibody induces B-cell activation in humans and mice,…”
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Inhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B-cell priming and not impairment in antigen presentation by Rachmawati, Nurlaely Mida, Fukudome, Kenji, Tsuneyoshi, Naoko, Bahrun, Uleng, Tsukamoto, Hiroki, Yanagibashi, Tsutomu, Nagai, Yoshinori, Takatsu, Kiyoshi, Ohta, Shoichiro, Kimoto, Masao

“…Stimulation of Toll-like receptor 4 (TLR4) induces not only innate but also adaptive immune responses, and has been suggested to exert adjuvant effects…”
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Induction of Long-Term Lipopolysaccharide Tolerance by an Agonistic Monoclonal Antibody to the Toll-Like Receptor 4/MD-2 Complex by Ohta, Shoichiro, Bahrun, Uleng, Shimazu, Rintaro, Matsushita, Hidetomo, Fukudome, Kenji, Kimoto, Masao

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Regulatory Roles for CD14 and Phosphatidylinositol in the Signaling via Toll-like Receptor 4-MD-2 by Akashi, Sachiko, Ogata, Hirotaka, Kirikae, Fumiko, Kirikae, Teruo, Kawasaki, Kiyoshi, Nishijima, Masahiro, Shimazu, Rintaro, Nagai, Yoshinori, Fukudome, Kenji, Kimoto, Masao, Miyake, Kensuke

“…The complex consisting of Toll-like receptor 4 (TLR4) and associated MD-2 signals the presence of lipopolysaccharide (LPS) when it is expressed in cell lines…”
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The Functional and Structural Properties of MD-2 Required for Lipopolysaccharide Binding Are Absent in MD-1 by Tsuneyoshi, Naoko, Fukudome, Kenji, Kohara, Jun, Tomimasu, Rika, Gauchat, Jean-Francois, Nakatake, Hiroshi, Kimoto, Masao

“…MD-1 and MD-2 are secretory glycoproteins that exist on the cell surface in complexes with transmembrane proteins. MD-1 is anchored by radioprotective 105…”
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Preparation and characterization of truncated human lipopolysaccharide-binding protein in Escherichia coli by Kohara, Jun, Tsuneyoshi, Naoko, Gauchat, Jean-François, Kimoto, Masao, Fukudome, Kenji

“…Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria, and is the causative agent of endotoxin shock. LPS induces signal…”
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Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor by Fukudome, K, Ye, X, Tsuneyoshi, N, Tokunaga, O, Sugawara, K, Mizokami, H, Kimoto, M

“…Protein C is an important regulatory mechanism of blood coagulation. Protein C functions as an anticoagulant when converted to the active serine protease form…”
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The Endothelial Cell Protein C Receptor (EPCR) Functions as a Primary Receptor for Protein C Activation on Endothelial Cells in Arteries, Veins, and Capillaries by Ye, Xiaofen, Fukudome, Kenji, Tsuneyoshi, Naoko, Satoh, Toshimi, Tokunaga, Osamu, Sugawara, Keishin, Mizokami, Hiroshi, Kimoto, Masao

“…Plasma protein C functions as an anticoagulant when it is converted to the active form of serine protease. Protein C activation has been found to be mediated…”
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Expression and anticoagulant function of the endothelial cell protein C receptor (EPCR) in cancer cell lines by Tsuneyoshi, N, Fukudome, K, Horiguchi, S, Ye, X, Matsuzaki, M, Toi, M, Suzuki, K, Kimoto, M

“…Induction of procoagulant factors in malignant cells is considered to be the major cause of coagulation disorders in cancer. Thrombomodulin (TM), a negative…”
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Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation by Eguchi, Kosei, Manabe, Ichiro, Oishi-Tanaka, Yumiko, Ohsugi, Mitsuru, Kono, Nozomu, Ogata, Fusa, Yagi, Nobuhiro, Ohto, Umeharu, Kimoto, Masao, Miyake, Kensuke, Tobe, Kazuyuki, Arai, Hiroyuki, Kadowaki, Takashi, Nagai, Ryozo

“…Consumption of foods high in saturated fatty acids (FAs) as well as elevated levels of circulating free FAs are known to be associated with T2D. Though…”
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