Search Results - "Kimmel, Gregory J."

Intra-tumor heterogeneity, turnover rate and karyotype space shape susceptibility to missegregation-induced extinction by Kimmel, Gregory J, Beck, Richard J, Yu, Xiaoqing, Veith, Thomas, Bakhoum, Samuel, Altrock, Philipp M, Andor, Noemi

“…The phenotypic efficacy of somatic copy number alterations (SCNAs) stems from their incidence per base pair of the genome, which is orders of magnitudes…”
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Time scales and wave formation in non-linear spatial public goods games by Kimmel, Gregory J, Gerlee, Philip, Altrock, Philipp M

“…The co-evolutionary dynamics of competing populations can be strongly affected by frequency-dependent selection and spatial population structure. As…”
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Spatial clustering of CD68+ tumor associated macrophages with tumor cells is associated with worse overall survival in metastatic clear cell renal cell carcinoma by Chakiryan, Nicholas H, Kimmel, Gregory J, Kim, Youngchul, Hajiran, Ali, Aydin, Ahmet M, Zemp, Logan, Katende, Esther, Nguyen, Jonathan, Lopez-Blanco, Neale, Chahoud, Jad, Spiess, Philippe E, Fournier, Michelle, Dhillon, Jasreman, Wang, Liang, Moran-Segura, Carlos, El-Kenawi, Asmaa, Mulé, James, Altrock, Philipp M, Manley, Brandon J

“…Immune infiltration is typically quantified using cellular density, not accounting for cellular clustering. Tumor-associated macrophages (TAM) activate…”
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Two-dimensional adaptive dynamics of evolutionary public goods games: finite-size effects on fixation probability and branching time by Johnson, Brian, Altrock, Philipp M., Kimmel, Gregory J.

“…Public goods games (PGGs) describe situations in which individuals contribute to a good at a private cost, but others can free-ride by receiving a share of the…”
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Geospatial characterization of immune cell distributions and dynamics across the microenvironment in clear cell renal cell carcinoma by Chakiryan, Nicholas H, Kim, Youngchul, Berglund, Anders, Chang, Andrew, Kimmel, Gregory J, Hajiran, Ali, Nguyen, Jonathan, Moran-Segura, Carlos, Saeed-Vafa, Daryoush, Katende, Esther N, Lopez-Blanco, Neale, Chahoud, Jad, Rappold, Phillip, Spiess, Philippe E, Fournier, Michelle, Jeong, Daniel, Wang, Liang, Teer, Jamie K, Dhillon, Jasreman, Kuo, Fengshen, Hakimi, Abraham Ari, Altrock, Philipp M, Mulé, James J, Manley, Brandon J

“…IntroductionIn clear cell renal cell carcinoma (ccRCC), tumor-associated macrophage (TAM) induction of CD8+T cells into a terminally exhausted state has been…”
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The roles of T cell competition and stochastic extinction events in chimeric antigen receptor T cell therapy by Kimmel, Gregory J, Locke, Frederick L, Altrock, Philipp M

“…Chimeric antigen receptor (CAR) T cell therapy is a remarkably effective immunotherapy that relies on expansion of engineered CAR T cells, after…”
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Correction to 'The roles of T-cell competition and stochastic extinction events in CAR T-cell therapy' by Kimmel, Gregory J, Locke, Frederick L, Altrock, Philipp M

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Integrating Mathematical Modeling with High-Throughput Imaging Explains How Polyploid Populations Behave in Nutrient-Sparse Environments by Kimmel, Gregory J, Dane, Mark, Heiser, Laura M, Altrock, Philipp M, Andor, Noemi

“…Breast cancer progresses in a multistep process from primary tumor growth and stroma invasion to metastasis. Nutrient-limiting environments promote chemotaxis…”
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Edge effect pinning in mesoscopic superconducting strips with non-uniform distribution of defects by Kimmel, Gregory J., Glatz, Andreas, Vinokur, Valerii M., Sadovskyy, Ivan A.

“…Transport characteristics of nano-sized superconducting strips and bridges are determined by an intricate interplay of surface and bulk pinning. In the…”
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spatialTIME and iTIME: R package and Shiny application for visualization and analysis of immunofluorescence data by Creed, Jordan H, Wilson, Christopher M, Soupir, Alex C, Colin-Leitzinger, Christelle M, Kimmel, Gregory J, Ospina, Oscar E, Chakiryan, Nicholas H, Markowitz, Joseph, Peres, Lauren C, Coghill, Anna, Fridley, Brooke L

“…Abstract Summary Multiplex immunofluorescence (mIF) staining combined with quantitative digital image analysis is a novel and increasingly used technique that…”
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Parallel magnetic field suppresses dissipation in superconducting nanostrips by Wang, Yong-Lei, Glatz, Andreas, Kimmel, Gregory J., Aranson, Igor S., Thoutam, Laxman R., Xiao, Zhi-Li, Berdiyorov, Golibjon R., Peeters, François M., Crabtree, George W., Kwok, Wai-Kwong

“…The motion of Abrikosov vortices in type-II superconductors results in a finite resistance in the presence of an applied electric current. Elimination or…”
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Extensions and analysis of worst-case parameter in weighted Jacobi's method for solving second order implicit PDEs by Kimmel, Gregory J., Glatz, Andreas

“…The optimal Jacobi parameter (ω) in Jacobi's iterative method is obtained for specific classes of matrices. We define ωopt as the worst-case optimal parameter…”
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Circulating tumor DNA adds specificity to PET after axicabtagene ciloleucel in large B-cell lymphoma by Dean, Erin A., Kimmel, Gregory J., Frank, Matthew J., Bukhari, Ali, Hossain, Nasheed M., Jain, Michael D., Dahiya, Saurabh, Miklos, David B., Altrock, Philipp M., Locke, Frederick L.

“…•MTV and ctDNA did not correlate with evidence of disease 1 month after axi-cel in large B-cell lymphoma, suggesting ongoing therapy response.•ctDNA can aid…”
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Geospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma by Chakiryan, Nicholas H., Kimmel, Gregory J., Kim, Youngchul, Johnson, Joseph O., Clark, Noel, Hajiran, Ali, Chang, Andrew, Aydin, Ahmet M., Zemp, Logan, Katende, Esther, Chahoud, Jad, Ferrall-Fairbanks, Meghan C., Spiess, Philippe E., Francis, Natasha, Fournier, Michelle, Dhillon, Jasreman, Park, Jong Y., Wang, Liang, Mulé, James J., Altrock, Philipp M., Manley, Brandon J.

“…Cancer-associated fibroblasts (CAF) are highly prevalent cells in the tumor microenvironment in clear cell renal cell carcinoma (ccRCC). CAFs exhibit a…”
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Neighborhood size-effects shape growing population dynamics in evolutionary public goods games by Kimmel, Gregory J., Gerlee, Philip, Brown, Joel S., Altrock, Philipp M.

“…An evolutionary game emerges when a subset of individuals incur costs to provide benefits to all individuals. Public goods games (PGG) cover the essence of…”
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Re: Simulation analysis for tumor radiotherapy based on three‐component mathematical models by Ferrall‐Fairbanks, Meghan C., Glazar, Daniel J., Brady, Renee J., Kimmel, Gregory J., Zahid, Mohammad U., Altrock, Philipp M., Enderling, Heiko

“…[...]we would like to point out selected discrepancies and inaccuracies with regards to these specific claims, in addition to several discrepancies in the…”
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Abstract 5490: Scales and dynamics of intratumor heterogeneity by Ferrall-Fairbanks, Meghan C., Kimmel, Gregory J., Altrock, Philipp M.

“…Abstract Current dogma stipulates that more heterogenous tumor cell populations results from compounding genetic and epigenetic changes and instability,…”
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Integrating mathematical modeling with high throughput imaging explains how polyploid populations invade nutrient-sparse environments by Kimmel, Gregory J., Dane, Mark, Heiser, Laura M., Altrock, Philipp M., Andor, Noemi

“…Breast cancer progresses in a multistep process from primary tumor growth and stroma invasion to metastasis. Nutrient-limiting environments promote chemotaxis…”
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Abstract PO-034: Non-random spatial clustering of tumor associated macrophages is associated with poor survival in metastatic RCC patients receiving immunotherapy by Kimmel, Gregory J., Chakiryan, Nicholas H., Kim, Youngchul, Hajiran, Ali J., Aydin, Ahmet M., Nguyen, Jonathan V., Moran-Segura, Carlos M., Dhillon, Jasreman, Altrock, Philipp, Manley, Brandon J.

“…Abstract INTRODUCTION Tumor associated macrophages (TAM) stimulate tumor proliferation and facilitate immune escape via production of immunosuppressive…”
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Parallel magnetic field suppresses dissipation in superconducting nanostrips by Wang, Yong-Lei, Glatz, Andreas, Kimmel, Gregory J., Aranson, Igor S., Thoutam, Laxman R., Xiao, Zhi-Li, Berdiyorov, Golibjon R., Peeters, François M., Crabtree, George W., Kwok, Wai-Kwong

“…The motion of Abrikosov vortices in type-II superconductors results in a finite resistance in the presence of an applied electric current. Elimination or…”
Get full text