Search Results - "Kimmel, D.B"

Biologic and pathologic aspects of osteocytes in the setting of medication-related osteonecrosis of the jaw (MRONJ) by Aguirre, J.I., Castillo, E.J., Kimmel, D.B.

“…Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe, debilitating condition affecting patients with cancer and patients with…”
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Mechanism of Action, Pharmacokinetic and Pharmacodynamic Profile, and Clinical Applications of Nitrogen-containing Bisphosphonates by Kimmel, D.B.

“…Nitrogen-containing bisphosphonates (nBPs) are bone-specific agents that inhibit farnesyl diphosphate synthase. nBPs’ strong affinity for bone, and not for…”
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Preventing or controlling periodontitis reduces the occurrence of osteonecrosis of the jaw (ONJ) in rice rats (Oryzomys palustris) by Castillo, E.J., Messer, J.G., Abraham, A.M., Jiron, J.M., Alekseyenko, A.V., Israel, R., Thomas, S., Gonzalez-Perez, G.M., Croft, S., Gohel, A., Bhattacharyya, I., Yarrow, J.F., Novince, C.M., Kimmel, D.B., Aguirre, J.I.

“…Osteonecrosis of the jaw (ONJ) is an adverse event that requires association of both systemic risk factors, such as powerful anti-resorptives (pARs; e.g…”
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Issues in modern bone histomorphometry by Recker, R.R, Kimmel, D.B, Dempster, D, Weinstein, R.S, Wronski, T.J, Burr, D.B

“…Abstract This review reports on proceedings of a bone histomorphometry session conducted at the Fortieth International IBMS Sun Valley Skeletal Tissue Biology…”
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Anti-vascular endothelial growth factor antibody monotherapy causes destructive advanced periodontitis in rice rats (Oryzomys palustris) by Messer, J.G., Castillo, E.J., Abraham, A.M., Jiron, J.M., Israel, R., Yarrow, J.F., Thomas, S., Reynolds, M.C., Wnek, R.D., Jorgensen, M., Wanionok, N., Van Poznak, C., Bhattacharyya, I., Kimmel, D.B., Aguirre, J.I.

“…Angiogenesis inhibitors (AgI) are commonly used in combination chemotherapy protocols to treat cancer, and have been linked to osteonecrosis of the jaw (ONJ)…”
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Age-Related Periodontitis and Alveolar Bone Loss in Rice Rats by Aguirre, J.I, Akhter, M.P, Neuville, K.G, Trcalek, C.R, Leeper, A.M, Williams, A.A, Rivera, M, Kesavalu, L, Ke, H.Z, Liu, M, Kimmel, D.B

“…Highlights • Rice rats fed a standard diet developed periodontitis (PD) by age 30 wks. • A high sucrose and casein (H-SC) diet accelerated the development of…”
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Transmenopausal changes in osteocyte lacunar volume in adult human trabecular bone by Kimmel, D.B, Akhter, M.P, Recker, R, Fong, T, Coats, J

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Effects of PTH(1–34) and estrogen status on osteocyte lacunar properties in rats by Kimmel, D.B, Fong, T, Akhter, M.P, Coats, J, Wronski, T

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Inhibition of vascular endothelial growth factor in young adult mice causes low bone blood flow and bone strength with no effect on bone mass in trabecular regions by Lane, N E, Nyman, J S, Uppuganti, S, Chaudhari, A J, Aguirre, J I, Shidara, K, Liu, X P, Yao, W, Kimmel, D B

“…To determine the effect of an antibody to vascular endothelial growth factor (VEGF) on bone blood flow, bone strength, and bone mass in the young adult mouse…”
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Osteocyte lacunar properties in adult human bone by Akhter, M.P, Candell, S, Recker, R.R, Fong, T, Coats, J, Kimmel, D.B

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Estrogen status and PTH effects on osteocyte lacunae in rats by Kimmel, D.B, Fong, T, Candell, S, Coats, J, Akhter, M.P, Wronski, T.J

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Effects of odanacatib on bone turnover and osteoclast morphology in the lumbar vertebra of ovariectomized adult rhesus monkeys by Scott, K.R, Pennypacker, B, Cusick, T, Duong⁎, L.T, Kimmel, D.B

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Preclinical models of medication-related osteonecrosis of the jaw (MRONJ) by Aguirre, J.I., Castillo, E.J., Kimmel, D.B.

“…Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event affecting patients with cancer and patients with osteoporosis who…”
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Maintenance of cancellous bone in ovariectomized, human parathyroid hormone [hPTH(1-84)]-treated rats by estrogen, risedronate, or reduced hPTH by Iwaniec, U.T., SamnegÅrd, E., Cullen, D.M., Kimmel, D.B.

“…This study compares effects of maintenance doses of human parathyroid hormone [hPTH(1-84)], 17β-estradiol (E 2), and risedronate on distal femur bone mineral…”
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Maintenance of cortical bone in human parathyroid hormone(1-84)-treated ovariectomized rats by Samnegård, E, Iwaniec, U.T, Cullen, D.M, Kimmel, D.B, Recker, R.R

“…The purpose of this cross-sectional study was to evaluate the effects of human parathyroid hormone(1-84) (hPTH) followed by maintenance treatment with…”
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Characterization of in vivo strain in the rat tibia during external application of a four-point bending load by Akhter, M P, Raab, D M, Turner, C H, Kimmel, D B, Recker, R R

“…This paper describes a technique for characterizing strains and stresses induced in vivo in the rat tibia during application of an external four-point bending…”
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Bone response to alternate‐day mechanical loading of the rat tibia by Raab‐Cullen, D.M., Akhter, M.P., Kimmel, D.B., Recker, R.R.

“…Mechanical loading of the living skeleton influences bone formation, mass, and strength. The primary purpose of the present study was to examine the influence…”
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Periosteal bone formation stimulated by externally induced bending strains by Raab‐Cullen, D.M., Akhter, M.P., Kimmel, D.B., Recker, R.R.

“…The rat tibia four‐point bending model is a new mechanical loading model in which force is applied through external pads to the rat lower limb. The advantages…”
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Zoledronic acid increases the prevalence of medication-related osteonecrosis of the jaw in a dose dependent manner in rice rats (Oryzomys palustris) with localized periodontitis by Messer, J.G., Mendieta Calle, J.L., Jiron, J.M., Castillo, E.J., Van Poznak, C., Bhattacharyya, N., Kimmel, D.B., Aguirre, J.I.

“…Investigate role of dose/duration of zoledronic acid (ZOL), a powerful anti-resorptive (pAR), on prevalence of medication-related osteonecrosis of the jaw…”
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Musculoskeletal recovery following hindlimb immobilization in adult female rats by Maeda, H, Kimmel, D B, Raab, D M, Lane, N E

“…Bone loss during immobilization is well known. Common medical treatments of aged individuals that involve temporary immobilization may create an iatrogenic…”
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