Clinical significance of laboratory diagnostics of coxyellosis in children

Clinical significance of laboratory diagnostics of coxyellosis in children

The urgency of the problem of coxyellosis in children is determined by the endemic nature of this pathology for a number of regions of Russia. The purpose of the study: to evaluate the results of diagnosis of coxyellosis in children using the methods of complement binding reaction (RSC), enzyme immu...

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Bibliographic Details
Published in:Klinicheskaia laboratornaia diagnostika Vol. 65; no. 12; p. 767
Main Authors: Kimirilova, Olga Gennadjevna, Kharchenko, G A
Format: Journal Article
Language:English
Published: Russia (Federation) 29-12-2020
Subjects:
Adolescent
Child
Clinical Laboratory Techniques
Coxiella
Enzyme-Linked Immunosorbent Assay
Gram-Negative Bacterial Infections - diagnosis
Humans
Polymerase Chain Reaction
Retrospective Studies
Russia
Sensitivity and Specificity
Russia
coxiellosis
RSC
children
PCR
laboratory diagnostics
ELISA
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Summary:The urgency of the problem of coxyellosis in children is determined by the endemic nature of this pathology for a number of regions of Russia. The purpose of the study: to evaluate the results of diagnosis of coxyellosis in children using the methods of complement binding reaction (RSC), enzyme immunoassay (ELISA), and polymerase chain reaction (PCR). Retrospective analysis of the survey on Coxiella in 3 groups of children aged 7 to 17 years: group 1 (n=30) method RSK; group 2 (n=34) - by ELISA; group 3 (n=35) - PCR, were hospitalized in GBUZ «Regional clinical infectious hospital named. A. M. Nicholi» Astrakhan in the period from January 2010 to January 2020. The most informative methods of diagnosis of coxyellosis in children during the first 7 days from the onset of the disease is the PCR reaction (specificity-94%, sensitivity-91%), after the 7th day of the disease ELISA (specificity -91%, sensitivity - 94%).The sensitivity of the RSC method is 70%, the specificity is 87%.
ISSN:0869-2084
DOI:10.18821/0869-2084-2020-65-12-767-770