Search Results - "Kimbrel, Erin A"

Current status of pluripotent stem cells: moving the first therapies to the clinic by Kimbrel, Erin A., Lanza, Robert

“…Key Points Human pluripotent stem cells (PSCs) can give rise to any cell type in the body. PSC derivatives are being developed for therapeutic use in diseases…”
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Human Somatic Cell Nuclear Transfer Using Adult Cells by Chung, Young Gie, Eum, Jin Hee, Lee, Jeoung Eun, Shim, Sung Han, Sepilian, Vicken, Hong, Seung Wook, Lee, Yumie, Treff, Nathan R., Choi, Young Ho, Kimbrel, Erin A., Dittman, Ralph E., Lanza, Robert, Lee, Dong Ryul

“…Derivation of patient-specific human pluripotent stem cells via somatic cell nuclear transfer (SCNT) has the potential for applications in a range of…”
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Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells by Feng, Qiang, Shabrani, Namrata, Thon, Jonathan N., Huo, Hongguang, Thiel, Austin, Machlus, Kellie R., Kim, Kyungho, Brooks, Julie, Li, Feng, Luo, Chenmei, Kimbrel, Erin A., Wang, Jiwu, Kim, Kwang-Soo, Italiano, Joseph, Cho, Jaehyung, Lu, Shi-Jiang, Lanza, Robert

“…Human induced pluripotent stem cells (iPSCs) provide a potentially replenishable source for the production of transfusable platelets. Here, we describe a…”
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Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties by Kimbrel, Erin A, Kouris, Nicholas A, Yavanian, Gregory J, Chu, Jianlin, Qin, Yu, Chan, Ann, Singh, Ram P, McCurdy, Deborah, Gordon, Lynn, Levinson, Ralph D, Lanza, Robert

“…Mesenchymal stem cells (MSCs) are being tested in a wide range of human diseases; however, loss of potency and inconsistent quality severely limit their use…”
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Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice by Lu, Shi-Jiang, Li, Feng, Yin, Hong, Feng, Qiang, Kimbrel, Erin A, Hahm, Eunsil, Thon, Jonathan N, Wang, Wei, Italiano, Joseph E, Cho, Jaehyung, Lanza, Robert

“…Platelets play an essential role in hemostasis and atherothrombosis. Owing to their short storage time, there is con- stant demand for this life-saving blood…”
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Human ESC-Derived MSCs Outperform Bone Marrow MSCs in the Treatment of an EAE Model of Multiple Sclerosis by Wang, Xiaofang, Kimbrel, Erin A., Ijichi, Kumiko, Paul, Debayon, Lazorchak, Adam S., Chu, Jianlin, Kouris, Nicholas A., Yavanian, Gregory J., Lu, Shi-Jiang, Pachter, Joel S., Crocker, Stephen J., Lanza, Robert, Xu, Ren-He

“…Current therapies for multiple sclerosis (MS) are largely palliative, not curative. Mesenchymal stem cells (MSCs) harbor regenerative and immunosuppressive…”
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Screening a Compound Library to Identify Additives That Boost Cytochrome P450 Enzyme Function in Vascularised Liver Spheres by Lucendo-Villarin, Baltasar, Wang, Yu, Mallanna, Sunil K, Kimbrel, Erin A, Hay, David C

“…To accurately study human organ function and disease 'in the dish', it is necessary to develop reliable cell-based models that closely track human physiology…”
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Human embryonic stem cell-derived mesenchymal cells preserve kidney function and extend lifespan in NZB/W F1 mouse model of lupus nephritis by Thiel, Austin, Yavanian, Gregory, Nastke, Maria-Dorothea, Morales, Peter, Kouris, Nicholas A., Kimbrel, Erin A., Lanza, Robert

“…Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). However, the inability to…”
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Next-generation stem cells — ushering in a new era of cell-based therapies by Kimbrel, Erin A., Lanza, Robert

“…Naturally occurring stem cells isolated from humans have been used therapeutically for decades. This has primarily involved the transplantation of primary…”
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The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor Binding by Giangrande, P H, Kimbrel, E A, Edwards, D P, McDonnell, D P

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Human Hemangioblast-Derived Mesenchymal Stem Cells Promote Islet Engraftment in a Minimal Islet Mass Transplantation Model in Mice by Bertera, Suzanne, Knoll, Michael F, Knoll, Carmela, Hara, Hidetaka, Kimbrel, Erin A, Kouris, Nickolas A, Lanza, Robert, Philips, Brett E, Garciafigueroa, Yesica, Giannoukakis, Nick, Cooper, David K C, Trucco, Massimo, Bottino, Rita

“…Islet transplantation can restore glycemic control in patients with type 1 diabetes. Using this procedure, the early stages of engraftment are often crucial to…”
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Systematic in vivo structure-function analysis of p300 in hematopoiesis by Kimbrel, Erin A., Lemieux, Madeleine E., Xia, Xiaobo, Davis, Tina N., Rebel, Vivienne I., Kung, Andrew L.

“…Cyclic adenosine monophosphate response element binding (CREB)–binding protein (CBP) and p300 are multidomain transcriptional coactivators that help assemble…”
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In Vivo Pharmacodynamic Imaging of Proteasome Inhibition by Kimbrel, Erin A., Davis, Tina N., Bradner, James E., Kung, Andrew L.

“…Inhibiting the proteolytic activity of the 26S proteasome has been shown to have selective apoptotic effects on cancer cells and to be clinically efficacious…”
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Pluripotent stem cells: the last 10 years by Kimbrel, Erin A, Lanza, Robert

“…Pluripotent stem cells (PSCs) can differentiate into virtually any cell type in the body, making them attractive for both regenerative medicine and drug…”
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Potential Clinical Applications for Human Pluripotent Stem Cell-Derived Blood Components by Kimbrel, Erin A., Lu, Shi-Jiang

“…The ability of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) to divide indefinitely without losing pluripotency and to…”
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Treatment of perianal fistulas with human embryonic stem cell-derived mesenchymal stem cells: a canine model of human fistulizing Crohn's disease by Ferrer, Lluís, Kimbrel, Erin A, Lam, Andrea, Falk, Elizabeth B, Zewe, Christine, Juopperi, Tarja, Lanza, Robert, Hoffman, Andrew

“…To evaluate the safety and efficacy of intralesional injection of human embryonic stem cell (hESC)-derived mesenchymal stem/stromal cells (MSCs) in canine anal…”
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The Promise and Therapeutic Potential of Human ES and iPS Cells by Lu, Shi-Jiang, Lee, Randall J., Napoli, Claudio, Oh, Steve, Kimbrel, Erin A., Feng, Qiang

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Hope for regenerative treatments: toward safe transplantation of human pluripotent stem-cell-based therapies by Kimbrel, Erin A, Lanza, Robert

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Stomping out barriers for hRBC mouse models by Kimbrel, Erin A., Lanza, Robert

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Human ESC-Derived MSCs Outperform Bone Marrow MSCs in the Treatment of an EAE Model of Multiple Sclerosis by Wang, Xiaofang, Kimbrel, Erin A, Ijichi, Kumiko, Paul, Debayon, Lazorchak, Adam S, Chu, Jianlin, Kouris, Nicholas A, Yavanian, Gregory J, Lu, Shi-Jiang, Pachter, Joel S, Crocker, Stephen J, Lanza, Robert, Xu, Ren-He

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