Search Results - "Kimblin, Nicola"

Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major by Kramer, Susanne, Kimblin, Nicola C, Carrington, Mark

“…CCCH type zinc finger proteins are RNA binding proteins with regulatory functions at all stages of mRNA metabolism. The best-characterized member,…”
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In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies by Peters, Nathan C, Egen, Jackson G, Secundino, Nagila, Debrabant, Alain, Kimblin, Nicola, Kamhawi, Shaden, Lawyer, Phillip, Fay, Michael P, Germain, Ronald N, Sacks, David

“…Infection with the obligate intracellular protozoan Leishmania is thought to be initiated by direct parasitization of macrophages, but the early events…”
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Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor by Macleod, Olivia J. S., Cook, Alexander D., Webb, Helena, Crow, Mandy, Burns, Roisin, Redpath, Maria, Seisenberger, Stefanie, Trevor, Camilla E., Peacock, Lori, Schwede, Angela, Kimblin, Nicola, Francisco, Amanda F., Pepperl, Julia, Rust, Steve, Voorheis, Paul, Gibson, Wendy, Taylor, Martin C., Higgins, Matthew K., Carrington, Mark

“…African trypanosomes are extracellular pathogens of mammals and are exposed to the adaptive and innate immune systems. Trypanosomes evade the adaptive immune…”
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Vector transmission of leishmania abrogates vaccine-induced protective immunity by Peters, Nathan C, Kimblin, Nicola, Secundino, Nagila, Kamhawi, Shaden, Lawyer, Phillip, Sacks, David L

“…Numerous experimental vaccines have been developed to protect against the cutaneous and visceral forms of leishmaniasis caused by infection with the obligate…”
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Quantification of the infectious dose of Leishmania major transmitted to the skin by single sand flies by Kimblin, Nicola, Peters, Nathan, Debrabant, Alain, Secundino, Nagila, Egen, Jackson, Lawyer, Phillip, Fay, Michael P, Kamhawi, Shaden, Sacks, David

“…Leishmaniasis is transmitted between mammalian hosts by the bites of bloodsucking vector sand flies. The dose of parasites transmitted to the mammalian host…”
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Demonstration of Genetic Exchange During Cyclical Development of Leishmania in the Sand Fly Vector by Akopyants, Natalia S, Kimblin, Nicola, Secundino, Nagila, Patrick, Rachel, Peters, Nathan, Lawyer, Phillip, Dobson, Deborah E, Beverley, Stephen M, Sacks, David L

“…Genetic exchange has not been shown to be a mechanism underlying the extensive diversity of Leishmania parasites. We report here evidence that the invertebrate…”
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Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies by Secundino, Nagila, Kimblin, Nicola, Peters, Nathan C, Lawyer, Phillip, Capul, Althea A, Beverley, Stephen M, Turco, Salvatore J, Sacks, David

“…Leishmania synthesize abundant phosphoglycan-containing molecules made up of [Gal-Man-PO₄] repeating units, including the surface lipophosphoglycan (LPG), and…”
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Molecular genetic analysis of purine nucleobase transport in Leishmania major by Ortiz, Diana, Sanchez, Marco A, Pierce, Steven, Herrmann, Timo, Kimblin, Nicola, Archie Bouwer, H.G, Landfear, Scott M

“…Leishmania major and all other parasitic protozoa are unable to synthesize purines de novo and are therefore reliant upon uptake of preformed purines from…”
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Developmentally regulated instability of the GPI-PLC mRNA is dependent on a short-lived protein factor by Webb, Helena, Burns, Roisin, Ellis, Louise, Kimblin, Nicola, Carrington, Mark

“…The expression of the vast majority of protein coding genes in trypanosomes is regulated exclusively at the post-transcriptional level. Developmentally…”
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Vector Transmission of Leishmania Abrogates Vaccine-Induced Protective Immunity: e1000484 by Peters, Nathan C, Kimblin, Nicola, Secundino, Nagila, Kamhawi, Shaden, Lawyer, Phillip, Sacks, David L

“…Numerous experimental vaccines have been developed to protect against the cutaneous and visceral forms of leishmaniasis caused by infection with the obligate…”
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Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies: Proteophosphoglycan protects L. major by Secundino, Nagila, Kimblin, Nicola, Peters, Nathan C., Lawyer, Phillip, Capul, Althea A., Beverley, Stephen M., Turco, Salvatore J., Sacks, David

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A novel strategy to identify the location of necessary and sufficient cis-acting regulatory mRNA elements in trypanosomes by Webb, Helena, Burns, Roisin, Kimblin, Nicola, Ellis, Louise, Carrington, Mark

“…Expression of nearly all protein coding genes in trypanosomes is regulated post-transcriptionally, predominantly at the level of mRNA half-life. The…”
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