Search Results - "Kim, Yujin E"

Molecular chaperone functions in protein folding and proteostasis by Kim, Yujin E, Hipp, Mark S, Bracher, Andreas, Hayer-Hartl, Manajit, Hartl, F Ulrich

“…The biological functions of proteins are governed by their three-dimensional fold. Protein folding, maintenance of proteome integrity, and protein homeostasis…”
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Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors by Kim, Yujin E., Hosp, Fabian, Frottin, Frédéric, Ge, Hui, Mann, Matthias, Hayer-Hartl, Manajit, Hartl, F. Ulrich

“…Huntington’s disease is one of several neurodegenerative disorders characterized by the aggregation of polyglutamine (polyQ)-expanded mutant protein. How polyQ…”
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Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration by Chan, Jonah R, Langen, Ralf, Kim, Yujin E, Chen, Jeannie

“…A polarity-sensitive annexin-based biosensor called pSIVA becomes strongly fluorescent only after reversibly binding to the plasma membrane. pSIVA allows…”
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A Helical Hairpin Region of Soluble Annexin B12 Refolds and Forms a Continuous Transmembrane Helix at Mildly Acidic pH by Kim, Yujin E., Isas, Jose Mario, Haigler, Harry T., Langen, Ralf

“…Annexins are soluble proteins that are best known for their ability to undergo reversible Ca2+-dependent binding to the surface of phospholipid bilayers…”
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Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis by Langen, Ralf, Chan, Jonah R, Kim, Yujin E, Chen, Jeannie

“…Applications for noninvasive real-time imaging of apoptosis and neuronal degeneration are hindered by technical limitations in imaging strategies and by…”
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A Compact β Model of huntingtin Toxicity by Zhang, Qi Charles, Yeh, Tzu-lan, Leyva, Alfonso, Frank, Leslie G., Miller, Jason, Kim, Yujin E., Langen, Ralf, Finkbeiner, Steven, Amzel, Mario L., Ross, Christopher A., Poirier, Michelle A.

“…Huntington disease results from an expanded polyglutamine region in the N terminus of the huntingtin protein. HD pathology is characterized by neuronal…”
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ESCAPE: database for integrating high-content published data collected from human and mouse embryonic stem cells by Xu, Huilei, Baroukh, Caroline, Dannenfelser, Ruth, Chen, Edward Y, Tan, Christopher M, Kou, Yan, Kim, Yujin E, Lemischka, Ihor R, Ma'ayan, Avi

“…High content studies that profile mouse and human embryonic stem cells (m/hESCs) using various genome-wide technologies such as transcriptomics and proteomics…”
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Effect of Pseudorepeat Rearrangement on α-Synuclein Misfolding, Vesicle Binding, and Micelle Binding by Rao, Jampani Nageswara, Kim, Yujin E., Park, Leena S., Ulmer, Tobias S.

“…The pathological and physiological hallmarks of the protein α-synuclein (aS) are its misfolding into cytotoxic aggregates and its binding to synaptic vesicles,…”
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The Conserved Core Domains of Annexins A1, A2, A5, and B12 Can Be Divided into Two Groups with Different Ca2+-Dependent Membrane-Binding Properties by Patel, Darshana R, Isas, J. Mario, Ladokhin, Alexey S, Jao, Christine C, Kim, Yujin E, Kirsch, Thorsten, Langen, Ralf, Haigler, Harry T

“…The hallmark of the annexin super family of proteins is Ca2+-dependent binding to phospholipid bilayers, a property that resides in the conserved core domain…”
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Calcium- and Membrane-Induced Changes in the Structure and Dynamics of Three Helical Hairpins in Annexin B12 by Isas, Jose Mario, Kim, Yujin E, Jao, Christine C, Hegde, Prabhavati B, Haigler, Harry T, Langen, Ralf

“…Annexins are a family of soluble proteins that can undergo reversible Ca2+-dependent interaction with the interfacial region of phospholipid membranes. The…”
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Transcriptional Inhibition of (GGGGCC) c9orf72 Hexanucleotide Repeat Expansion in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis by Kim, Yujin E

“…Microsatellite repeat mutations are long expansions of repetitive DNA in the genome. Two Dozen of devastating neurological disorders are associated with the…”
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Effect of Pseudorepeat Rearrangement upon α-Synuclein Misfolding, Vesicle Binding and Micelle Binding by Rao, Jampani Nageswara, Kim, Yujin E., Park, Leena S., Ulmer, Tobias S.

“…The pathological and physiological hallmarks of the protein α-synuclein are its misfolding into cytotoxic aggregates and its binding to synaptic vesicles,…”
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The folding, misfolding and refolding of membrane proteins and the design of a phosphatidylserine-specific membrane sensor by Kim, Yujin E

“…The interaction between proteins and membranes underlies many important biological processes. Proteins influence the structure and fluidity of membranes and…”
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The Conserved Core Domains of Annexins A1, A2, A5, and B12 Can Be Divided into Two Groups with Different Ca 2+ -Dependent Membrane-Binding Properties by Patel, Darshana R., Isas, J. Mario, Ladokhin, Alexey S., Jao, Christine C., Kim, Yujin E., Kirsch, Thorsten, Langen, Ralf, Haigler, Harry T.

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