Search Results - "Kim, Yong Nyun"

Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis by Kim, Yong-Nyun, Koo, Kyung Hee, Sung, Jee Young, Yun, Un-Jung, Kim, Hyeryeong

“…Metastasis is a multistep process including dissociation of cancer cells from primary sites, survival in the vascular system, and proliferation in distant…”
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Rab8 and Rabin8-Mediated Tumor Formation by Hyperactivated EGFR Signaling via FGFR Signaling by Choi, Junghwa, Sung, Jee Young, Lee, Saerom, Yoo, Jungyoen, Rongo, Christopher, Kim, Yong-Nyun, Shim, Jaegal

“…The epidermal growth factor receptor (EGFR) signaling is important for normal development, such as vulval development in , and hyperactivation of the EGFR is…”
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Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis by Kang, Donghee, Jung, Seung Hee, Lee, Gun‐Hee, Lee, Seongju, Park, Heon Joo, Ko, Young‐Gyu, Kim, Yong‐Nyun, Lee, Jae‐Seon

“…Cellular senescence can be triggered by various intrinsic and extrinsic stimuli. We previously reported that silencing of 3′‐phosphoadenosine 5′‐phosphosulfate…”
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Deacetylation of CHK2 by SIRT1 protects cells from oxidative stress-dependent DNA damage response by Kwon, Jiyun, Lee, Suhee, Kim, Yong-Nyun, Lee, In Hye

“…Growing evidence indicates that metabolic signaling pathways are interconnected to DNA damage response (DDR). However, factors that link metabolism to DDR…”
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Anti-cancer effect of doxorubicin is mediated by downregulation of HMG-Co A reductase via inhibition of EGFR/Src pathway by Yun, Un-Jung, Lee, Ji-Hye, Shim, Jaegal, Yoon, Kyungsil, Goh, Sung-Ho, Yi, Eun Hee, Ye, Sang-Kyu, Lee, Jae-Seon, Lee, Hyunji, Park, Jongsun, Lee, In Hye, Kim, Yong-Nyun

“…Doxorubicin is a widely used DNA damage-inducing anti-cancer drug. However, its use is limited by its dose-dependent side effects, such as cardiac toxicity…”
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Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues by Jung, Seung Hee, Lee, Minyoung, Park, Hyun A, Lee, Hyung Chul, Kang, Donghee, Hwang, Hyun Jung, Park, Chanho, Yu, Dong-Min, Jung, Yu Ri, Hong, Mi-Na, Kim, Yong-Nyun, Park, Heon Joo, Ko, Young-Gyu, Lee, Jae-Seon

“…Cellular senescence refers to an irreversible growth arrest that is triggered by various intrinsic and extrinsic stresses. Many recent studies have…”
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Dynamic and coordinated single‐molecular interactions at TM4SF5‐enriched microdomains guide invasive behaviors in 2‐ and 3‐dimensional environments by Kim, Hye‐Jin, Kwon, Sojung, Nam, Seo Hee, Jung, Jae Woo, Kang, Minkyung, Ryu, Jihye, Kim, Ji Eon, Cheong, Jin‐Gyu, Cho, Chang Yun, Kim, Somi, Song, Dae‐Geun, Kim, Yong‐Nyun, Kim, Tai Young, Jung, Min‐Kyo, Lee, Kyung‐Min, Pack, Chan‐Gi, Lee, Jung Weon

“…Membrane proteins sense extracellular cues and transduce intracellular signaling to coordinate directionality and speed during cellular migration. They are…”
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TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma by Kang, Donghee, Hwang, Hyun Jung, Baek, Yurim, Sung, Jee Young, Kim, KyeongJin, Park, Heon Joo, Ko, Young-Gyu, Kim, Yong-Nyun, Lee, Jae-Seon

“…The ubiquitin-proteasome system is a vital protein degradation system that is involved in various cellular processes, such as cell cycle progression,…”
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Reprogramming of T cell‐derived small extracellular vesicles using IL2 surface engineering induces potent anti‐cancer effects through miRNA delivery by Jung, Dokyung, Shin, Sanghee, Kang, Sung‐Min, Jung, Inseong, Ryu, Suyeon, Noh, Soojeong, Choi, Sung‐Jin, Jeong, Jongwon, Lee, Beom Yong, Kim, Kwang‐Soo, Kim, Christine Seulki, Yoon, Jong Hyuk, Lee, Chan‐Hyeong, Bucher, Felicitas, Kim, Yong‐Nyun, Im, Sin‐Hyeog, Song, Byoung‐Joon, Yea, Kyungmoo, Baek, Moon‐Chang

“…T cell‐derived small extracellular vesicles (sEVs) exhibit anti‐cancer effects. However, their anti‐cancer potential should be reinforced to enhance clinical…”
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AP2M1 Supports TGF-β Signals to Promote Collagen Expression by Inhibiting Caveolin Expression by Lee, Saerom, Lim, Ga-Eun, Kim, Yong-Nyun, Koo, Hyeon-Sook, Shim, Jaegal

“…The extracellular matrix (ECM) is important for normal development and disease states, including inflammation and fibrosis. To understand the complex…”
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Ginsenoside Rp1, A Ginsenoside Derivative, Augments Anti-Cancer Effects of Actinomycin D via Downregulation of an AKT-SIRT1 Pathway by Yun, Un-Jung, Lee, In Hye, Lee, Jae-Seon, Shim, Jaegal, Kim, Yong-Nyun

“…Novel strategies for overcoming multidrug resistance are urgently needed to improve chemotherapy success and reduce side effects. Ginsenosides, the main active…”
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Substituted Syndecan-2-Derived Mimetic Peptides Show Improved Antitumor Activity over the Parent Syndecan-2-Derived Peptide by Jang, Bohee, Kim, Ayoung, Lee, Yejin, Hwang, Jisun, Sung, Jee-Young, Jang, Eun-Ju, Kim, Yong-Nyun, Yun, Ji-Hye, Han, Jeongmin, Song, Ji-Joon, Lee, Weontae, Oh, Eok-Soo

“…We previously showed that a synthetic peptide (S2-P) corresponding to a portion of the human syndecan-2 (SDC2) sequence can bind to the pro-domain of matrix…”
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Anti-Tumor Effects of Sodium Meta-Arsenite in Glioblastoma Cells with Higher Akt Activities by Lee, Eun Jeong, Sung, Jee Young, Koo, Kyung Hee, Park, Jong Bae, Kim, Dae Hong, Shim, Jaegal, Lee, Chang Hoon, Park, Jongsun, Kim, Yong-Nyun

“…Glioblastoma is a type of aggressive brain tumor that grows very fast and evades surrounding normal brain, lead to treatment failure. Glioblastomas are…”
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ICSBP-induced PD-L1 enhances osteosarcoma cell growth by Sung, Jee Young, Kim, June Hyuk, Kang, Hyun Guy, Park, Jong Woong, Park, Seog-Yun, Park, Byung-Kiu, Kim, Yong-Nyun

“…BackgroundInterferon (IFN) consensus sequence binding protein (ICSBP) is a transcription factor induced by IFN-γ. We previously reported that ICSBP expression…”
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Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells by Jung, Joo Eun, Kim, Hong Sook, Lee, Chang Seok, Park, Dae-Hun, Kim, Yong-Nyun, Lee, Min-Jae, Lee, Jung Weon, Park, Jong-Wan, Kim, Myung-Suk, Ye, Sang Kyu, Chung, Myung-Hee

“…Tumor angiogenesis is required for tumor development and is stimulated by angiogenic inducers like VEGF (vascular endothelial growth factor). Our previous…”
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STAT3-RANTES autocrine signaling is essential for tamoxifen resistance in human breast cancer cells by Yi, Eun Hee, Lee, Chang Seok, Lee, Jin-Ku, Lee, Young Ju, Shin, Min Kyung, Cho, Chung-Hyun, Kang, Keon Wook, Lee, Jung Weon, Han, Wonshik, Noh, Dong-Young, Kim, Yong-Nyun, Cho, Ik-Hyun, Ye, Sang-Kyu

“…The acquisition of tamoxifen resistance is a major therapeutic problem in breast cancer. We developed a tamoxifen-resistant MCF-7 (TRM-7) cell line to…”
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Immunomodulatory Activities of the Benzoxathiole Derivative BOT-4-One Ameliorate Pathogenic Skin Inflammation in Mice by Lee, Hyun Gyu, Cho, Nam-chul, Jeong, Ae Jin, Li, Yu-Chen, Rhie, Sung-Ja, Choi, Jung Sook, Lee, Kwang-Ho, Kim, Youngsoo, Kim, Yong-Nyun, Kim, Myoung-Hwan, Pae, Ae Nim, Ye, Sang-Kyu, Kim, Byung-Hak

“…T-cell-mediated immune responses play an important role in body protection. However, aberrantly activated immune responses are responsible for inflammatory and…”
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An in vivo C. elegans model system for screening EGFR-inhibiting anti-cancer drugs by Bae, Young-Ki, Sung, Jee Young, Kim, Yong-Nyun, Kim, Sunshin, Hong, Kyeong Man, Kim, Heung Tae, Choi, Min Sung, Kwon, Jae Young, Shim, Jaegal

“…The epidermal growth factor receptor (EGFR) is a well-established target for cancer treatment. EGFR tyrosine kinase (TK) inhibitors, such as gefinitib and…”
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Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3‐mediated cancer development by Seo, Eun‐Bi, Jang, Hyun‐Jun, Kwon, Sun‐Ho, Kwon, Yong‐Jin, Kim, Seul‐Ki, Lee, Song‐Hee, Jeong, Ae Jin, Shin, Hyun Mu, Kim, Yong‐Nyun, Ma, Stephanie, Kim, Haeryoung, Lee, Yun‐Han, Suh, Pann‐Ghill, Ye, Sang‐Kyu

“…Phospholipase C gamma 1 (PLCγ1) plays an oncogenic role in several cancers, alongside its usual physiological roles. Despite studies aimed at identifying the…”
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SEZ6L2 Is an Important Regulator of Drug-Resistant Cells and Tumor Spheroid Cells in Lung Adenocarcinoma by Lee, Jang-Seok, Kim, Hee Yeon, Won, Bomyi, Kang, Sang Won, Kim, Yong-Nyun, Jang, Hyonchol

“…Many lung cancer deaths result from relapses in distant organs, such as the brain or bones, after standard chemotherapy. For cancer cells to spread to other…”
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