Search Results - "Kim, Yong Bum"

Nonclinical safety assessment and immunogenicity of rVSVInd(GML)-mspSGtc vaccine for SARS-CoV-2 in rabbits by Park, Heeseon, Jang, Min Seong, Choi, Jung-Ah, Kim, Woojin, Kim, Yong-Bum, Kim, Na Hyung, Choi, Eunsil, Son, Hwa-Young, Han, Kang-Hyun

“…•The rVSVInd(GML)-mspSGtc SARS-CoV-2 vaccine was tested in rabbits.•rVSVInd(GML)-mspSGtc produced a robust dose-dependent immune response.•Our findings…”
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Long-chain perfluoroalkyl carboxylates induce cytoskeletal abnormalities and activate epithelial–mesenchymal transition in both renal cell carcinoma 3D cultures and Caki-1 xenografted mouse model by Lee, Byoung-Seok, Kim, Younhee, Park, Heejin, Im, Wan-Jung, Han, Hyoung-Yun, Kim, Yong-Bum, Lim, SunHwa, Yoo, Min Heui

“…[Display omitted] •LCPFACs increased the expression of EMT-related proteins in Caki-1 2D/3D cultures.•Cytoskeletal abnormality was evident in all cells treated…”
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Bisphenol A impairs renal function by reducing Na+/K+-ATPase and F-actin expression, kidney tubule formation in vitro and in vivo by Yoo, Min Heui, Lee, Seung-Jin, Kim, Woojin, Kim, Younhee, Kim, Yong-Bum, Moon, Kyoung–Sik, Lee, Byoung-Seok

“…The kidney proximal tubule is responsible for reabsorbing water and NaCl to maintain the homeostasis of the body fluids, electrolytes, and nutrients. Thus,…”
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Preparing pathological data to develop an artificial intelligence model in the nonclinical study by Hwang, Ji-Hee, Lim, Minyoung, Han, Gyeongjin, Park, Heejin, Kim, Yong-Bum, Park, Jinseok, Jun, Sang-Yeop, Lee, Jaeku, Cho, Jae-Woo

“…Artificial intelligence (AI)-based analysis has recently been adopted in the examination of histological slides via the digitization of glass slides using a…”
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Anti‐Inflammatory Lignans from the Roots of Asarum heterotropoides var. mandshuricum and Their Mechanism of Action by Thanh Le, Thi, Tuan Ha, Manh, Han, Kang‐Hyun, Kim, Yong‐Bum, Ah Kim, Jeong, Sun Min, Byung

“…Bioassay‐guided fractionation of Asarum heterotropoides var. mandshuricum F. Maekawa (Aristolochiaceae) root extract led to the isolation and characterization…”
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Application of multiple-finding segmentation utilizing Mask R-CNN-based deep learning in a rat model of drug-induced liver injury by Baek, Eun Bok, Lee, Jaeku, Hwang, Ji-Hee, Park, Heejin, Lee, Byoung-Seok, Kim, Yong-Bum, Jun, Sang-Yeop, Her, Jun, Son, Hwa-Young, Cho, Jae-Woo

“…Drug-induced liver injury (DILI) presents significant diagnostic challenges, and recently artificial intelligence-based deep learning technology has been used…”
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Subacute dermal toxicity of perfluoroalkyl carboxylic acids: comparison with different carbon-chain lengths in human skin equivalents and systemic effects of perfluoroheptanoic acid in Sprague Dawley rats by Han, Ji-Seok, Jang, Sumi, Son, Hwa-Young, Kim, Yong-Bum, Kim, Younhee, Noh, Jung-Ho, Kim, Mi-Jeong, Lee, Byoung-Seok

“…Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are used in various fields but raise concerns regarding human health and environmental consequences…”
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An International Collaborative Animal Study of the Carcinogenicity of Mobile Phone Radiofrequency Radiation: Considerations for Preparation of a Global Project by Ahn, Young Hwan, Imaida, Katsumi, Kim, Yong‐Bum, Han, Kang‐Hyun, Pack, Jeong‐Ki, Kim, Nam, Jeon, Sang Bong, Lee, Ae‐Kyoung, Choi, Hyung Do, Wang, Jianqing, Kawabe, Mayumi, Kim, Hye Sun

“…Radiofrequency radiation (RFR) was classified as a “possible” human carcinogen in 2011, which caused great public concern. A carcinogenicity study by the…”
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Genotoxicity assessment of root extracts of Paeonia lactiflora Pall by Bak, Su-Min, Back, Seng-Min, Kim, Da Yeon, Jeung, Na-Young, Kim, Nan-Young, Yang, Jun-Young, Han, Kang-Hyun, Kim, Yong-Bum, Min, Byung Sun, Lee, Byoung-Seok, Park, Seong-Hoon

“…The roots of Paeonia lactiflora Pall., (Paeoniae Radix, PL) are a well-known herbal remedy used to treat fever, rheumatoid arthritis, systemic lupus…”
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Protein arginine methyltransferase 1 contributes to the development of allergic rhinitis by promoting the production of epithelial-derived cytokines by Park, Ji-Yeon, Choi, Joo-Hee, Lee, Sang-Nam, Cho, Hyung-Ju, Ahn, Ji-Suk, Kim, Yong-Bum, Park, Do-Yong, Park, Sang Chul, Kim, Soo-In, Kang, Min-Jung, Jang, Ah-Ra, Ahn, Jae-Hun, Lee, Tae-Sung, Kim, Dong-Yeon, Shin, Sung Jae, Yoon, Joo-Heon, Park, Jong-Hwan

“…Arginine methylation is a posttranslational modification mediated by protein arginine methyltransferases (PRMTs). Although previous studies have shown that…”
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Field Uniformity Assessment of a Reverberation Chamber for a Large-Scale Animal Study by Jeon, Sangbong, Lee, Ae-Kyoung, Wang, Jianqing, Pack, Jeong-Ki, Kim, Yong-Bum, Ahn, Young Hwan, Imaida, Katsumi, Choi, Hyung-Do

“…An exposure system was designed and implemented for the purpose of joint large-scale animal experiments conducted in Korea and Japan using a reverberation…”
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Development of Adaptive Gripper Enhancing Power Grasp Range and Linearity by Rhee, Issac, Soo Kim, Chun, Jeong, Heeyeon, Um, Seunghwan, Jae Moon, Seung, Son, Yeonggwang, Bum Kim, Yong, Sang Jung, Ho, Choi, Hyouk Ryeol

“…This paper presents a gripper structure that improves the known potential limitations of curved fingertip movements and the restricted range of objects that…”
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A comparative study on the implementation of deep learning algorithms for detection of hepatic necrosis in toxicity studies by Hwang, Ji-Hee, Lim, Minyoung, Han, Gyeongjin, Park, Heejin, Kim, Yong-Bum, Park, Jinseok, Jun, Sang-Yeop, Lee, Jaeku, Cho, Jae-Woo

“…Deep learning has recently become one of the most popular methods of image analysis. In non-clinical studies, several tissue slides are generated to…”
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Artificial Intelligence-Assisted Image Analysis of Acetaminophen-Induced Acute Hepatic Injury in Sprague-Dawley Rats by Baek, Eun Bok, Hwang, Ji-Hee, Park, Heejin, Lee, Byoung-Seok, Son, Hwa-Young, Kim, Yong-Bum, Jun, Sang-Yeop, Her, Jun, Lee, Jaeku, Cho, Jae-Woo

“…Although drug-induced liver injury (DILI) is a major target of the pharmaceutical industry, we currently lack an efficient model for evaluating liver toxicity…”
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Natural course of fatty liver in 36,195 South Korean adults by Sung, Ki-Chul, Lee, Mi-Yeon, Lee, Jong-Young, Lee, Sung-Ho, Kim, Yong-Bum, Song, Won-Jun, Huh, Ji-Hye, Park, Jin-Sun, Shin, Jeong-Hun, Seo, Mi Hae, Kim, Seong-Hwan, Kim, Sun H.

“…Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease, and yet the natural course remains unclear. Study population included…”
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Increased serum bile acid concentration following low-dose chronic administration of thioacetamide in rats, as evidenced by metabolomic analysis by Jeong, Eun Sook, Kim, Gabin, Shin, Ho Jung, Park, Se-Myo, Oh, Jung-Hwa, Kim, Yong-Bum, Moon, Kyoung-Sik, Choi, Hyung-Kyoon, Jeong, Jayoung, Shin, Jae-Gook, Kim, Dong Hyun

“…A liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS)-based metabolomics approach was employed to identify endogenous metabolites as potential…”
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Segmentation algorithm can be used for detecting hepatic fibrosis in SD rat by Hwang, Ji-Hee, Lim, Minyoung, Han, Gyeongjin, Park, Heejin, Kim, Yong-Bum, Park, Jinseok, Jun, Sang-Yeop, Lee, Jaeku, Cho, Jae-Woo

“…Liver fibrosis is an early stage of liver cirrhosis. As a reversible lesion before cirrhosis, liver failure, and liver cancer, it has been a target for drug…”
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Quality evaluation of Panax ginseng roots using a rapid resolution LC-QTOF/MS-based metabolomics approach by Lee, Dae-Young, Kim, Jae Kwang, Shrestha, Sabina, Seo, Kyeong-Hwa, Lee, Youn-Hyung, Noh, Hyung-Jun, Kim, Geum-Soog, Kim, Yong-Bum, Kim, Seung-Yu, Baek, Nam-In

“…Korean ginseng (Panax ginseng C.A. Meyer) contains several types of ginsenosides, which are considered the major active medicinal components of ginseng. The…”
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Reference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies by Park, Hyun-Kyu, Cho, Jae-Woo, Lee, Byoung-Seok, Park, Heejin, Han, Ji-Seok, Yang, Mi-Jin, Im, Wan-Jung, Park, Do-Yong, Kim, Woo-Jin, Han, Su-Cheol, Kim, Yong-Bum

“…Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is…”
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Time course of polyhexamethyleneguanidine phosphate-induced lung inflammation and fibrosis in mice by Song, Jeongah, Kim, Woojin, Kim, Yong-Bum, Kim, Bumseok, Lee, Kyuhong

“…Pulmonary fibrosis is a chronic progressive disease with unknown etiology and has poor prognosis. Polyhexamethyleneguanidine phosphate (PHMG-P) causes acute…”
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