Search Results - "Kim, Yeoun jin"

Reproducibility Assessment of Relative Quantitation Strategies for LC−MS Based Proteomics by Kim, Yeoun Jin, Zhan, Ping, Feild, Brian, Ruben, Steven M, He, Tao

“…The reproducibility of a given method for relative quantitation governs the reliability of liquid chromatography−mass spectrometry (LC−MS) based differential…”
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The addition of FAIMS increases targeted proteomics sensitivity from FFPE tumor biopsies by Sweet, Steve, Chain, David, Yu, Wen, Martin, Philip, Rebelatto, Marlon, Chambers, Andrew, Cecchi, Fabiola, Kim, Yeoun Jin

“…Mass spectrometry-based targeted proteomics allows objective protein quantitation of clinical biomarkers from a single section of formalin-fixed,…”
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A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells by Cesi, Giulia, Philippidou, Demetra, Kozar, Ines, Kim, Yeoun Jin, Bernardin, Francois, Van Niel, Guillaume, Wienecke-Baldacchino, Anke, Felten, Paul, Letellier, Elisabeth, Dengler, Sonja, Nashan, Dorothee, Haan, Claude, Kreis, Stephanie

“…Drug resistance remains an unsolved clinical issue in oncology. Despite promising initial responses obtained with BRAF and MEK kinase inhibitors, resistance to…”
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Quantification of SAA1 and SAA2 in lung cancer plasma using the isotype-specific PRM assays by Kim, Yeoun Jin, Gallien, Sebastien, El-Khoury, Victoria, Goswami, Panchali, Sertamo, Katriina, Schlesser, Marc, Berchem, Guy, Domon, Bruno

“…The quantification of plasma proteins using the high resolution and accurate mass (HR/AM)‐based parallel reaction monitoring (PRM) method provides an immediate…”
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Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer by El-Khoury, Victoria, Béland, Mélanie, Schritz, Anna, Kim, Sang-Yoon, Nazarov, Petr V., Gaboury, Louis, Sertamo, Katriina, Bernardin, François, Batutu, Roxane, Antunes, Laurent, Bennett, Catherine W., Faÿs, François, Berchem, Guy, Kim, Yeoun Jin

“…Background Distinguishing lung adenocarcinoma (ADC) from squamous cell carcinoma (SCC) has a tremendous therapeutic implication. Sometimes, the commonly used…”
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Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue by Chambers, Andrew G., Chain, David C., Sweet, Steve M., Song, Zifeng, Martin, Philip L., Ellis, Matthew J., Rooney, Claire, Kim, Yeoun Jin

“…Background Quantification of drug-target binding is critical for confirming that drugs reach their intended protein targets, understanding the mechanism of…”
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Mass spectrometry–based detection and quantification of plasma glycoproteins using selective reaction monitoring by Kim, Yeoun Jin, Zaidi-Ainouch, Zaya, Gallien, Sebastien, Domon, Bruno

“…Mass spectrometry–based targeted proteomics is a rapidly expanding method for quantifying proteins in complex clinical samples such as plasma. In conjunction…”
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High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies by Toulmonde, Maud, Lucchesi, Carlo, Verbeke, Stéphanie, Crombe, Amandine, Adam, Julien, Geneste, Damien, Chaire, Vanessa, Laroche-Clary, Audrey, Perret, Raul, Bertucci, François, Bertolo, Frederic, Bianchini, Laurence, Dadone-Montaudie, Bérengère, Hembrough, Todd, Sweet, Steve, Kim, Yeoun Jin, Cecchi, Fabiola, Le Loarer, François, Italiano, Antoine

“…Undifferentiated pleomorphic sarcoma (UPS) is the most frequent, aggressive and less-characterized sarcoma subtype. This study aims to assess UPS molecular…”
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Identification of a Blood-Based Protein Biomarker Panel for Lung Cancer Detection by El-Khoury, Victoria, Schritz, Anna, Kim, Sang-Yoon, Lesur, Antoine, Sertamo, Katriina, Bernardin, François, Petritis, Konstantinos, Pirrotte, Patrick, Selinsky, Cheryl, Whiteaker, Jeffrey R, Zhang, Haizhen, Kennedy, Jacob J, Lin, Chenwei, Lee, Lik Wee, Yan, Ping, Tran, Nhan L, Inge, Landon J, Chalabi, Khaled, Decker, Georges, Bjerkvig, Rolf, Paulovich, Amanda G, Berchem, Guy, Kim, Yeoun Jin

“…Lung cancer is the deadliest cancer worldwide, mainly due to its advanced stage at the time of diagnosis. A non-invasive method for its early detection remains…”
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Structural Mass Spectrometry in Protein Therapeutics Discovery by Kim, Yeoun Jin, Doyle, Michael L

“…The protein therapeutics market is one of the highest growing segments of the pharmaceutical industry with an estimated global market value of $77 billion by…”
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Analysis of Viral Glycoproteins by MALDI-TOF Mass Spectrometry by Kim, Yeoun Jin, Freas, Amy, Fenselau, Catherine

“…Membrane glycoproteins were shown to be useful biomarkers of enveloped viruses using on-target deglycosylation and matrix-assisted laser…”
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Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts by Paggetti, Jerome, Haderk, Franziska, Seiffert, Martina, Janji, Bassam, Distler, Ute, Ammerlaan, Wim, Kim, Yeoun Jin, Adam, Julien, Lichter, Peter, Solary, Eric, Berchem, Guy, Moussay, Etienne

“…Exosomes derived from solid tumor cells are involved in immune suppression, angiogenesis, and metastasis, but the role of leukemia-derived exosomes has been…”
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Identification of 12Cysβ on tubulin as the binding site of tubulyzine by Kim, Yeoun Jin, Sackett, Dan L., Schapira, Matthieu, Walsh, Daniel P., Min, Jaeki, Pannell, Lewis K., Chang, Young-Tae

“…We have undertaken quantitative binding site studies in order to identify the binding site of the known microtubule destabilizing agents, the tubulyzines, in…”
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Structural Characterization of the Molten Globule State of Apomyoglobin by Limited Proteolysis and HPLC-Mass Spectrometry by Kim, Yeoun Jin, Kim, Young A, Park, Nokyoung, Son, Hyeon S, Kim, Kwang S, Hahn, Jong Hoon

“…A method to characterize the structural conformation of an acidic molten globule apomyoglobin (apoMb) at pH 4.2 was developed using limited proteolysis and…”
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Cell-free DNA and next-generation sequencing in the service of personalized medicine for lung cancer by Bennett, Catherine W, Berchem, Guy, Kim, Yeoun Jin, El-Khoury, Victoria

“…Personalized medicine has emerged as the future of cancer care to ensure that patients receive individualized treatment specific to their needs. In order to…”
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Global Extraction from Parallel Reaction Monitoring to Quantify Background Peptides for Improved Normalization and Quality Control in Targeted Proteomics by Chambers, Andrew G, Sweet, Steve M. M, Chain, David, Kim, Yeoun Jin

“…Mass spectrometry-based targeted proteomics employs heavy isotope-labeled proteins or peptides as standards to improve accuracy and precision. The input sample…”
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Targeted data-independent acquisition for mass spectrometric detection of RAS mutations in formalin-fixed, paraffin-embedded tumor biopsies by Kim, Yeoun Jin, Chambers, Andrew G., Cecchi, Fabiola, Hembrough, Todd

“…Genomic testing for KRAS and NRAS mutations in clinical biopsies of various cancers is routinely performed to predict futility of anti-epidermal growth factor…”
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Verification of the Biomarker Candidates for Non-small-cell Lung Cancer Using a Targeted Proteomics Approach by Kim, Yeoun Jin, Sertamo, Katriina, Pierrard, Marie-Aline, Mesmin, Cédric, Kim, Sang Yoon, Schlesser, Marc, Berchem, Guy, Domon, Bruno

“…Lung cancer, with its high metastatic potential and high mortality rate, is the worldwide leading cause of cancer-related deaths. High-throughput “omics”-based…”
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CLDN18/CLDN18.2 IHC assay comparison (SP455, 43-14A, EPR19202) and co-prevalence expression with other biomarkers in gastric carcinoma by Clements, Miranda E, Willis, Sophie E, Korade, Martin, Ortiz, Lorenzo, Zalesak-Kravec, Stephanie, Lombard, Cam, Richardson, Chris, Chambers, Andrew, Kim, Yeoun Jin, Tsao, Tsu-Shuen, Robida, Mark, Zaucha, Jan, Berry, Deborah, Jones, Gemma N, Barrett, Allison, Durham, Nick, Rebelatto, Marlon, Broggi, Maria, Thress, Kenneth S., Giraldo, Nicolas

“…4089 Background: Despite recent advances in treatment, gastric cancer (GC) remains the fourth leading cause of cancer-related mortality worldwide. Claudin 18.2…”
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Mechanistic Insight into the Inactivation of Carboxypeptidase A by α-Benzyl-2-oxo-1,3-oxazolidine-4-acetic Acid, a Novel Type of Irreversible Inhibitor for Carboxypeptidase A with No Stereospecificity by Chung, Sang J, Chung, Suhman, Lee, Hyun Soo, Kim, Eun-Jung, Oh, Kyung Seok, Choi, Hyuk Soon, Kim, Kwang S, Kim, Yeoun Jin, Hahn, Jong Hoon, Kim, Dong H

“…On the basis of the active site topology and enzymic catalytic mechanism of carboxypeptidase A (CPA), a prototypical zinc-containing proteolytic enzyme,…”
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