Search Results - "Kim, V. Narry"

A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing by Yu, Sha, Kim, V. Narry

“…RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most frequent and conserved type of RNA modification. The addition of…”
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TAIL-seq: Genome-wide Determination of Poly(A) Tail Length and 3′ End Modifications by Chang, Hyeshik, Lim, Jaechul, Ha, Minju, Kim, V. Narry

“…Global investigation of the 3′ extremity of mRNA (3′-terminome), despite its importance in gene regulation, has not been feasible due to technical challenges…”
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Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis by Kim, Young-Kook, Kim, Boseon, Kim, V. Narry

“…Biogenesis of canonical microRNAs (miRNAs) involves multiple steps: nuclear processing of primary miRNA (pri-miRNA) by DROSHA, nuclear export of precursor…”
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The Architecture of SARS-CoV-2 Transcriptome by Kim, Dongwan, Lee, Joo-Yeon, Yang, Jeong-Sun, Kim, Jun Won, Kim, V. Narry, Chang, Hyeshik

“…SARS-CoV-2 is a betacoronavirus responsible for the COVID-19 pandemic. Although the SARS-CoV-2 genome was reported recently, its transcriptomic architecture is…”
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Regulation of Poly(A) Tail and Translation during the Somatic Cell Cycle by Park, Jong-Eun, Yi, Hyerim, Kim, Yoosik, Chang, Hyeshik, Kim, V. Narry

“…Poly(A) tails are critical for mRNA stability and translation. However, recent studies have challenged this view, showing that poly(A) tail length and…”
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Bias-minimized quantification of microRNA reveals widespread alternative processing and 3′ end modification by Kim, Haedong, Kim, Jimi, Kim, Kijun, Chang, Hyeshik, You, Kwontae, Kim, V Narry

“…Abstract MicroRNAs (miRNAs) modulate diverse biological and pathological processes via post-transcriptional gene silencing. High-throughput small RNA…”
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Functional Anatomy of the Human Microprocessor by Nguyen, Tuan Anh, Jo, Myung Hyun, Choi, Yeon-Gil, Park, Joha, Kwon, S. Chul, Hohng, Sungchul, Kim, V. Narry, Woo, Jae-Sung

“…MicroRNA (miRNA) maturation is initiated by Microprocessor composed of RNase III DROSHA and its cofactor DGCR8, whose fidelity is critical for generation of…”
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Uridylation by TUT4 and TUT7 Marks mRNA for Degradation by Lim, Jaechul, Ha, Minju, Chang, Hyeshik, Kwon, S. Chul, Simanshu, Dhirendra K., Patel, Dinshaw J., Kim, V. Narry

“…Uridylation occurs pervasively on mRNAs, yet its mechanism and significance remain unknown. By applying TAIL-seq, we identify TUT4 and TUT7 (TUT4/7), also…”
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Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation by Lim, Jaechul, Kim, Dongwan, Lee, Young-Suk, Ha, Minju, Lee, Mihye, Yeo, Jinah, Chang, Hyeshik, Song, Jaewon, Ahn, Kwangseog, Kim, V Narry

“…RNA tails play integral roles in the regulation of messenger RNA (mRNA) translation and decay. Guanylation of the poly(A) tail was discovered recently, yet the…”
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mTAIL-seq reveals dynamic poly(A) tail regulation in oocyte-to-embryo development by Lim, Jaechul, Lee, Mihye, Son, Ahyeon, Chang, Hyeshik, Kim, V Narry

“…Eukaryotic mRNAs are subject to multiple types of tailing that critically influence mRNA stability and translatability. To investigate RNA tails at the genomic…”
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Dicer recognizes the 5′ end of RNA for efficient and accurate processing by Park, Jong-Eun, Heo, Inha, Tian, Yuan, Simanshu, Dhirendra K., Chang, Hyeshik, Jee, David, Patel, Dinshaw J., Kim, V. Narry

“…A hallmark of RNA silencing is a class of approximately 22-nucleotide RNAs that are processed from double-stranded RNA precursors by Dicer. Accurate processing…”
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Quantification of purified endogenous miRNAs with high sensitivity and specificity by Shin, Soochul, Jung, Yoonseok, Uhm, Heesoo, Song, Minseok, Son, Soomin, Goo, Jiyoung, Jeong, Cherlhyun, Song, Ji-Joon, Kim, V. Narry, Hohng, Sungchul

“…MicroRNAs (miRNAs) are short (19–24 nt) non-coding RNAs that suppress the expression of protein coding genes at the post-transcriptional level. Differential…”
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Mono-Uridylation of Pre-MicroRNA as a Key Step in the Biogenesis of Group II let-7 MicroRNAs by Heo, Inha, Ha, Minju, Lim, Jaechul, Yoon, Mi-Jeong, Park, Jong-Eun, Kwon, S. Chul, Chang, Hyeshik, Kim, V. Narry

“…RNase III Drosha initiates microRNA (miRNA) maturation by cleaving a primary miRNA transcript and releasing a pre-miRNA with a 2 nt 3′ overhang. Dicer…”
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Role of the small subunit processome in the maintenance of pluripotent stem cells by You, Kwon Tae, Park, Joha, Kim, V Narry

“…RNA-binding proteins (RBPs) play integral roles in gene regulation, yet only a small fraction of RBPs has been studied in the context of stem cells. Here we…”
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Short Structured RNAs with Low GC Content Are Selectively Lost during Extraction from a Small Number of Cells by Kim, Young-Kook, Yeo, Jinah, Kim, Boseon, Ha, Minju, Kim, V. Narry

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LIN28A Is a Suppressor of ER-Associated Translation in Embryonic Stem Cells by Cho, Jun, Chang, Hyeshik, Kwon, S. Chul, Kim, Baekgyu, Kim, Yoosik, Choe, Junho, Ha, Minju, Kim, Yoon Ki, Kim, V. Narry

“…LIN28 plays a critical role in developmental transition, glucose metabolism, and tumorigenesis. At the molecular level, LIN28 is known to repress maturation of…”
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The regulatory impact of RNA-binding proteins on microRNA targeting by Kim, Sukjun, Kim, Soyoung, Chang, Hee Ryung, Kim, Doyeon, Park, Junehee, Son, Narae, Park, Joori, Yoon, Minhyuk, Chae, Gwangung, Kim, Young-Kook, Kim, V. Narry, Kim, Yoon Ki, Nam, Jin-Wu, Shin, Chanseok, Baek, Daehyun

“…Argonaute is the primary mediator of metazoan miRNA targeting (MT). Among the currently identified >1,500 human RNA-binding proteins (RBPs), there are only a…”
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Conserved microRNA miR-8 controls body size in response to steroid signaling in Drosophila by Jin, Hua, Kim, V Narry, Hyun, Seogang

“…Body size determination is a process that is tightly linked with developmental maturation. Ecdysone, an insect maturation hormone, contributes to this process…”
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Photoactivatable ribonucleosides mark base-specific RNA-binding sites by Bae, Jong Woo, Kim, Sangtae, Kim, V. Narry, Kim, Jong-Seo

“…RNA-protein interaction can be captured by crosslinking and enrichment followed by tandem mass spectrometry, but it remains challenging to pinpoint RNA-binding…”
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Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA by Heo, Inha, Joo, Chirlmin, Cho, Jun, Ha, Minju, Han, Jinju, Kim, V. Narry

“…The precise control of microRNA (miRNA) biogenesis is critical for embryonic development and normal cellular functions, and its dysregulation is often…”
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