Search Results - "Kim, Susy A."

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria by Brust, Tarsis F, Morgenweck, Jenny, Kim, Susy A, Rose, Jamie H, Locke, Jason L, Schmid, Cullen L, Zhou, Lei, Stahl, Edward L, Cameron, Michael D, Scarry, Sarah M, Aubé, Jeffrey, Jones, Sara R, Martin, Thomas J, Bohn, Laura M

“…Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and…”
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Psychosocial Stress Delays Recovery of Postoperative Pain Following Incisional Surgery in the Rat by Arora, Vipin, Martin, Thomas J., Aschenbrenner, Carol A., Hayashida, Kenichiro, Kim, Susy A., Parker, Renee A., Eisenach, James C., Peters, Christopher M.

“…•Repeat social defeat (RSD) reduced weight gain and increased signs of depression but not anxiety in Sprague–Dawley rats.•Mixed effects growth curve analysis…”
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Opioid Self-administration in the Nerve-injured Rat by Martin, Thomas J., Kim, Susy A., Buechler, Nancy L., Porreca, Frank, Eisenach, James C.

“…Background Neuropathic pain is associated with several sensory abnormalities, including allodynia as well as spontaneous pain. Opioid intake in neuropathic…”
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Involvement of the Lateral Amygdala in the Antiallodynic and Reinforcing Effects of Heroin in Rats after Peripheral Nerve Injury by MARTIN, Thomas J, BUECHLER, Nancy L, KIM, Susy A, EWAN, Eric E, RUOYU XIAO, CHILDERS, Steven R

“…Neuropathic pain alters opioid self-administration in rats. The brain regions altered in the presence of neuropathic pain mediating these differences have not…”
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Nociceptive input after peripheral nerve injury results in cognitive impairment and alterations in primary afferent physiology in rats by Boada, M. Danilo, Ririe, Douglas G., Martin, Conner W., Martin, Salem J., Kim, Susy A., Eisenach, James C., Martin, Thomas J.

“…Pain alters cognitive performance through centrally mediated effects in the brain. In this study, we hypothesized that persistent activation of peripheral…”
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Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task by Martin, Thomas J, Strassburg, Tracy J, Grigg, Amanda L, Kim, Susy A, Ririe, Douglas G, Eisenach, James C

“…Both acute and chronic pain result in a number of behavioral symptoms in patients, including cognitive effects such as decreased attention and working memory…”
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Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats by Ririe, Douglas G, Boada, M Danilo, MacGregor, Megan K, Martin, Salem J, Strassburg, Tracy J, Kim, Susy A, Eisenach, James C, Martin, Thomas J

“…WHAT WE ALREADY KNOW ABOUT THIS TOPIC WHAT THIS ARTICLE TELLS US THAT IS NEW BACKGROUND:Cognitive capacity may be reduced from inflammation, surgery,…”
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Assessment of attention threshold in rats by titration of visual cue duration during the five choice serial reaction time task by Martin, Thomas J., Grigg, Amanda, Kim, Susy A., Ririe, Douglas G., Eisenach, James C.

“…•We report a novel variant of the 5CSRTT that systematically titrates the level of task difficulty.•This variant of the 5CSRTT reduces the training period…”
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Opioid self-administration in the nerve-injured rat : Relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics by MARTIN, Thomas J, KIM, Susy A, BUECHLER, Nancy L, PORRECA, Frank, EISENACH, James C

“…Neuropathic pain is associated with several sensory abnormalities, including allodynia as well as spontaneous pain. Opioid intake in neuropathic pain patients…”
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Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation by Martin, Thomas J., Kim, Susy A., Eisenach, James C.

“…Clonidine is approved for spinal administration against neuropathic pain, and reverses both spontaneous and elicited pain in humans following spinal…”
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Audiovisual Distraction Increases Prefrontal Cortical Neuronal Activity and Impairs Attentional Performance in the Rat by Ririe, Douglas G, Boada, MD, Schmidt, Benjamin S, Martin, Salem J, Kim, Susy A, Martin, Thomas J

“…Involvement of attentional processes is generally evidenced by disruption of behavior in the presence of distracting stimuli. The medial prefrontal cortex…”
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Differential involvement of mu-opioid receptors in the rostral versus caudal nucleus accumbens in the reinforcing effects of heroin in rats: evidence from focal injections of β-funaltrexamine by MARTIN, Thomas J, KIM, Susy A, LYUPINA, Yulia, SMITH, James E

“…The nucleus accumbens is a diverse and heterogeneous structure along its rostrocaudal axis. The influence of specific subpopulations of mu-opioid receptors…”
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Intermittent access to cocaine self‐administration impairs performance in a visual attention task in rats: effects of psychostimulants by Martin, Thomas J., Kim, Susy A., Eure, Mary M., Blough, Bruce E., Nader, Michael A.

“…Abstract only Cocaine abuse leads to a number of deficits in cognition, including attention. Several rodent models for attention have been developed, including…”
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Assessment of behavioral disruption in rats with abdominal inflammation using visual cue titration and the 5 choice serial reaction time task by Martin, Thomas J., Strassburg, Tracy J., Grigg, Amanda L., Kim, Susy A., Ririe, Douglas G., Eisenach, James C.

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Dose–Effect Functions for Cocaine Self-Administration: Effects of Schedule and Dosing Procedure by Sizemore, Glen M, Gaspard, Teresa M, Kim, Susy A, Walker, Lois E, Vrana, Sheila L, Dworkin, Steven I

“…Research related to determining how procedural variables can alter dose–effect functions for cocaine self-administration is limited. Toward clarifying the role…”
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A G Protein‐Biased Ligand of the Kappa Opioid Receptor is Antinociceptive and Antipruritic But Does Not Cause Sedation or Dysphoria by Brust, Tarsis F, Morgenweck, Jenny, Kim, Susy A, Rose, Jamie H, Locke, Jason L, Schmid, Cullen L, Zhou, Lei, Stahl, Edward L, Cameron, Michael D, Scarry, Sarah M, Aubé, Jeffrey, Jones, Sara R, Martin, Thomas J, Bohn, Laura M

“…Abstract only The kappa opioid receptor (KOR) has been pursued as a target to treat pain and pruritis (itch). In contrast to opioid narcotics that target…”
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Potent reinforcing effects of dihydroetorphine in rats by Martin, Thomas J, Kim, Susy A, Harris, Louis S, Smith, James E

“…Dihydroetorphine is a novel opioid that is an extremely potent analgesic in rodents. The reinforcing potency was determined in rats trained to self-administer…”
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Regional differences in mu and kappa opioid receptor G-protein activation in brain in male and female prairie voles by Martin, T.J, Sexton, T, Kim, S.A, Severino, A.L, Peters, C.M, Young, L.J, Childers, S.R

“…Highlights • Opioid stimulation of [35 S]GTPγS binding was validated in prairie vole brain. • Mu and kappa opioid stimulation was consistent with reported…”
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Differential involvement of mu-opioid receptors in the rostral versus caudal nucleus accumbens in the reinforcing effects of heroin in rats: evidence from focal injections of [beta]-funaltrexamine by Martin, Thomas J, Kim, Susy A, Lyupina, Yulia, Smith, James E

“…Rationale: The nucleus accumbens is a diverse and heterogeneous structure along its rostrocaudal axis. The influence of specific subpopulations of mu-opioid…”
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Effects of β-funaltrexamine on dose–effect curves for heroin self-administration in rats: comparison with alteration of [ 3H]DAMGO binding to rat brain sections by Martin, Thomas J., DeMontis, M.Graziella, Kim, Susy A., Sizemore, Glen M., Dworkin, Steven I., Smith, James E.

“…These studies were undertaken to determine the effects of μ-opioid receptor depletion through irreversible alkylation on the dose–effect curve for heroin…”
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