Search Results - "Kim, Sehui"
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Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areas
Published in European journal of cancer (1990) (01-11-2015)“…Highlights • We evaluate the PD-1/PD-Ls pathway molecules in pulmonary pleomorphic carcinoma (PC). • PD-L1 and PD-L2 are highly expressed in pulmonary PCs. •…”
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Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma
Published in Cell (13-06-2019)“…Mutational processes giving rise to lung adenocarcinomas (LADCs) in non-smokers remain elusive. We analyzed 138 LADC whole genomes, including 83 cases with…”
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Comparative analysis of PD-L1 expression between primary and metastatic pulmonary adenocarcinomas
Published in European journal of cancer (1990) (01-04-2017)“…Abstract Programmed death-ligand 1 (PD-L1) expression in pulmonary adenocarcinomas (pADCs) was implicated in predicting anti-PD-1/PD-L1 therapy efficacy…”
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In Vivo Near Infrared Virtual Intraoperative Surgical Photoacoustic Optical Coherence Tomography
Published in Scientific reports (12-10-2016)“…Since its first implementation in otolaryngological surgery nearly a century ago, the surgical microscope has improved the accuracy and the safety of…”
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Comparative analysis of the tumor immune-microenvironment of primary and brain metastases of non-small-cell lung cancer reveals organ-specific and EGFR mutation-dependent unique immune landscape
Published in Cancer Immunology, Immunotherapy (01-07-2021)“…Background To evaluate the characteristics of the tumor immune-microenvironment in brain metastases of non-small-cell lung cancer (NSCLC), we investigated the…”
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PD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lung
Published in Human pathology (01-12-2016)“…PD-1/PD-L1-targeted immunotherapy has emerged as a promising therapeutic strategy for pulmonary adenocarcinoma (pADC). Epithelial-to-mesenchymal transition…”
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Differences in tumor microenvironments between primary lung tumors and brain metastases in lung cancer patients: therapeutic implications for immune checkpoint inhibitors
Published in BMC cancer (07-01-2019)“…We aimed to compare intra- and extracranial responses to immune checkpoint inhibitors (ICIs) in lung cancer with brain metastases (BM), and to explore tumor…”
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Immunologic features of nontuberculous mycobacterial pulmonary disease based on spatially resolved whole transcriptomics
Published in BMC pulmonary medicine (13-08-2024)“…The immunologic features of nontuberculous mycobacterial pulmonary disease (NTM-PD) are largely unclear. This study investigated the immunologic features of…”
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Prognostic implications of intratumoral CD103+ tumor-infiltrating lymphocytes in pulmonary squamous cell carcinoma
Published in Oncotarget (21-02-2017)“…CD103 is the αE subunit of αEβ7 integrin that is expressed in tissue-resident memory T cells, where it promotes cytotoxic T cell responses against tumors…”
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Clinicopathological features of programmed cell death-1 and programmed cell death-ligand-1 expression in the tumor cells and tumor microenvironment of angioimmunoblastic T cell lymphoma and peripheral T cell lymphoma not otherwise specified
Published in Virchows Archiv : an international journal of pathology (01-07-2020)“…The expression patterns of programmed cell death-1 (PD-1) and programmed cell death-ligand-1 (PD-L1) and their clinicopathological implications were…”
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Eco-friendly synthesis of bioactive silver nanoparticles from black roasted gram (Cicer arietinum) for biomedical applications
Published in Scientific reports (02-10-2024)“…Green synthesis leverages biological resources such as plant extracts to produce cost-effectively and environmentally friendly NPs. In our study, silver…”
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Combined photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source
Published in Applied optics. Optical technology and biomedical optics (20-03-2013)“…We developed an integrated dual-modal photoacoustic and optical coherence tomography (PA-OCT) system using a single near-infrared supercontinuum laser source…”
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Prognostic stratification based on the levels of tumor-infiltrating myeloid-derived suppressor cells and PD-1/PD-L1 axis in locally advanced rectal cancer
Published in Frontiers in oncology (25-10-2022)“…Background Although rectal cancer remains somewhat sanctuary to the contemporary immunotherapy, there is increasing knowledge on clinical implications of…”
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Prognostic value of the association between MHC class I downregulation and PD-L1 upregulation in head and neck squamous cell carcinoma patients
Published in Scientific reports (22-05-2019)“…The purpose of this study was to evaluate the prognostic impact of major histocompatibility complex (MHC) class I expression and programmed death-ligand 1…”
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Programmed cell death ligand-1-mediated enhancement of hexokinase 2 expression is inversely related to T-cell effector gene expression in non-small-cell lung cancer
Published in Journal of experimental & clinical cancer research (12-11-2019)“…We investigated the role of PD-L1 in the metabolic reprogramming of non-small cell lung cancer (NSCLC). Changes in glycolysis-related molecules and glycolytic…”
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High tumor hexokinase-2 expression promotes a pro-tumorigenic immune microenvironment by modulating CD8+/regulatory T-cell infiltration
Published in BMC cancer (01-11-2022)“…Abstract Background Relationship between cancer cell glycolysis and the landscape of tumor immune microenvironment in human cancers was investigated. Methods…”
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MET Receptor Tyrosine Kinase Regulates the Expression of Co-Stimulatory and Co-Inhibitory Molecules in Tumor Cells and Contributes to PD-L1-Mediated Suppression of Immune Cell Function
Published in International journal of molecular sciences (01-09-2019)“…The MET tyrosine receptor kinase is essential for embryonic development and tissue regeneration by promoting cell survival, proliferation, migration, and…”
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High tumoral PD-L1 expression and low PD-1+ or CD8+ tumor-infiltrating lymphocytes are predictive of a poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system
Published in Oncoimmunology (02-09-2019)“…We investigated the clinicopathological role of the PD-1/PD-L1 pathway in primary diffuse large B-cell lymphoma of the central nervous system (PCNS-DLBCL)…”
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MET exon 14 skipping mutation in triple-negative pulmonary adenocarcinomas and pleomorphic carcinomas: an analysis of intratumoral MET status heterogeneity and clinicopathological characteristics
Published in Lung cancer (Amsterdam, Netherlands) (01-04-2017)“…Highlights • MET mutations is detected in 8.8% of triple-negative adenocarcinomas of the lung. • MET mutations is detected in 20% of pleomorphic carcinomas of…”
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Prognostic implications of tumor-infiltrating macrophages, M2 macrophages, regulatory T-cells, and indoleamine 2,3-dioxygenase-positive cells in primary diffuse large B-cell lymphoma of the central nervous system
Published in Oncoimmunology (03-07-2018)“…Primary diffuse large B-cell lymphoma of the central nervous system (CNS-DLBCL) is an aggressive disease with a poor prognosis. The status of the tumor immune…”
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