Search Results - "Kim, Sean L."

Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence by Garbern, Jessica C., Helman, Aharon, Sereda, Rebecca, Sarikhani, Mohsen, Ahmed, Aishah, Escalante, Gabriela O., Ogurlu, Roza, Kim, Sean L., Zimmerman, John F., Cho, Alexander, MacQueen, Luke, Bezzerides, Vassilios J., Parker, Kevin Kit, Melton, Douglas A., Lee, Richard T.

“…BACKGROUND:Current differentiation protocols to produce cardiomyocytes from human induced pluripotent stem cells (iPSCs) are capable of generating highly pure…”
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An autonomously swimming biohybrid fish designed with human cardiac biophysics by Lee, Keel Yong, Park, Sung-Jin, Matthews, David G, Kim, Sean L, Marquez, Carlos Antonio, Zimmerman, John F, Ardoña, Herdeline Ann M, Kleber, Andre G, Lauder, George V, Parker, Kevin Kit

“…Biohybrid systems have been developed to better understand the design principles and coordination mechanisms of biological systems. We consider whether two…”
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Fibre-infused gel scaffolds guide cardiomyocyte alignment in 3D-printed ventricles by Choi, Suji, Lee, Keel Yong, Kim, Sean L., MacQueen, Luke A., Chang, Huibin, Zimmerman, John F., Jin, Qianru, Peters, Michael M., Ardoña, Herdeline Ann M., Liu, Xujie, Heiler, Ann-Caroline, Gabardi, Rudy, Richardson, Collin, Pu, William T., Bausch, Andreas R., Parker, Kevin Kit

“…Hydrogels are attractive materials for tissue engineering, but efforts to date have shown limited ability to produce the microstructural features necessary to…”
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Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue by Park, Sung-Jin, Zhang, Donghui, Qi, Yan, Li, Yifei, Lee, Keel Yong, Bezzerides, Vassilios J, Yang, Pengcheng, Xia, Shutao, Kim, Sean L, Liu, Xujie, Lu, Fujian, Pasqualini, Francesco S, Campbell, Patrick H, Geva, Judith, Roberts, Amy E, Kleber, Andre G, Abrams, Dominic J, Pu, William T, Parker, Kevin Kit

“…BACKGROUND:Modeling of human arrhythmias with induced pluripotent stem cell–derived cardiomyocytes has focused on single-cell phenotypes. However, arrhythmias…”
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Recreating the heart's helical structure-function relationship with focused rotary jet spinning by Chang, Huibin, Liu, Qihan, Zimmerman, John F, Lee, Keel Yong, Jin, Qianru, Peters, Michael M, Rosnach, Michael, Choi, Suji, Kim, Sean L, Ardoña, Herdeline Ann M, MacQueen, Luke A, Chantre, Christophe O, Motta, Sarah E, Cordoves, Elizabeth M, Parker, Kevin Kit

“…Helical alignments within the heart's musculature have been speculated to be important in achieving physiological pumping efficiencies. Testing this…”
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Mussel-inspired 3D fiber scaffolds for heart-on-a-chip toxicity studies of engineered nanomaterials by Ahn, Seungkuk, Ardoña, Herdeline Ann M., Lind, Johan U., Eweje, Feyisayo, Kim, Sean L., Gonzalez, Grant M., Liu, Qihan, Zimmerman, John F., Pyrgiotakis, Georgios, Zhang, Zhenyuan, Beltran-Huarac, Juan, Carpinone, Paul, Moudgil, Brij M., Demokritou, Philip, Parker, Kevin Kit

“…Due to the unique physicochemical properties exhibited by materials with nanoscale dimensions, there is currently a continuous increase in the number of…”
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Spatiotemporal cell junction assembly in human iPSC-CM models of arrhythmogenic cardiomyopathy by Kim, Sean L., Trembley, Michael A., Lee, Keel Yong, Choi, Suji, MacQueen, Luke A., Zimmerman, John F., de Wit, Lousanne H.C., Shani, Kevin, Henze, Douglas E., Drennan, Daniel J., Saifee, Shaila A., Loh, Li Jun, Liu, Xujie, Parker, Kevin Kit, Pu, William T.

“…Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder that causes life-threatening arrhythmias and myocardial dysfunction. Pathogenic variants…”
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